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JAK Inhibition in Rheumatoid Arthritis

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References

  1. Coombs JH, Bloom BJ, Breedveld FC, et al. Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial. Ann Rheum Dis. 2010;69:413–6.

    Article  PubMed  CAS  Google Scholar 

  2. Kremer JM, Cohen S, Wilkinson B, et al: Safety and efficacy after 24 weeks dosing of oral JAK inhibitor CP-690,550 in combination with methotrexate in patients with active rheumatoid arthritis. Arthritis Rheum 2009, 60(S719):1925 (abstract).

    Google Scholar 

  3. Tanaka Y, Suzuki M, Nakamura H, et al: The oral JAK inhibitor CP-690,550 in combination with methotrexate is efficacious, safe and well tolerated in Japanese patients with active rheumatoid arthritis with an inadequate response to MTX alone. Abstract presented at the European League Against Rheumatism, Copenhagen, Denmark, June 10–13, 2009.

  4. Kanik K, Fleschmann RM, Cutolo M, et al: Phase 2B dose ranging monotherapy study of the oral JAK inhibitor CP-690,550 or adalimumab vs placebo in patients with active rheumatoid arthritis with an inadequate reponse to DMARDs. Ann Rheum Dis 2009, 68:123 OP-0159 (abstract).

    Google Scholar 

  5. Riese RJ, Krishnaswami S, Kremer J. Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes. Best Pract Res Clin Rheumatol. 2010;24:513–26.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Rheumatology and Clinical Immunology, University of Pittsburgh, S711 Biomedical Science Tower, 3500 Terrace Street, Pittsburgh, PA, 15261, USA

    Aarat M. Patel, Daniel Lupash, Douglas Chew, Marc C. Levesque & Larry W. Moreland

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  1. Aarat M. Patel
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  2. Daniel Lupash
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  3. Douglas Chew
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  4. Marc C. Levesque
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  5. Larry W. Moreland
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Correspondence to Larry W. Moreland.

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Patel, A.M., Lupash, D., Chew, D. et al. JAK Inhibition in Rheumatoid Arthritis. Curr Rheumatol Rep 13, 379–380 (2011). https://doi.org/10.1007/s11926-011-0196-4

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  • DOI: https://doi.org/10.1007/s11926-011-0196-4

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