Skip to main content

Advertisement

SpringerLink
Log in

Low- dose prednisolone in early rheumatoid arthritis

  • Clinical Trials Report
  • Published:
Current Rheumatology Reports Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Hench PS, Kendall EC, Slocumb CH, Polley HF: Effects of cortisone acetate and pituitar y ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions. Arch Med Interna 1950, 85:545–666.

    PubMed  CAS  Google Scholar 

  2. Saag K, Kirwan J: Glucocorticoid therapy in rheumatoid arthritis. In Modern Therapeutics in Rheumatic Diseases. Edited by Tsokos GC. Totowa, NJ: Humana Press, Inc.; 2001.

    Google Scholar 

  3. Michel BA, Bloch DA, Wolfe F, Fries J: Fractures in rheumatoid arthritis: an evaluation of associated risk factors. J Rheum 1993, 20:1666–1669.

    PubMed  CAS  Google Scholar 

  4. Capell HA, Madhok R, Hunter JA, et al.: Lack of radiological and clinical bene.t over two years of low dose prednisolone for rheumatoid arthritis: results of a randomized, controlled trial. Ann Rheum Dis 2004, 63:797–803.

    Article  PubMed  CAS  Google Scholar 

  5. Kirwan JR: The effect of glucocorticoids on joint destruction in rheumatoid arthritis. The Arthritis and Rheumatism Council Low-dose Glucocorticoid Study Group. N Engl J Med 1995, 333:142–146.

    Article  PubMed  CAS  Google Scholar 

  6. Rau R, Wassenberg S, Zeidler H: Low-dose prednisolone therapy (LDPT) retards radiographically detectable destruction in early rheumatoid arthritis: preliminary results of a multicenter, randomized, parallel, doubleblind study. Z Rheumatol 2000, 59(suppl 2):90–96.

    Google Scholar 

  7. van Everdingenm AA, Jacobs JW, Siewertsz Van Reesema DR, Bijlsma JW: Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, diseasemodifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial. Ann Intern Med 2002, 136:1–12.

    Google Scholar 

  8. van Everdingenm AA, Siewertsz van Reesema DR, Jacobs JW, Bijlsma JW: Low-dose glucocorticoids in early rheumatoid arthritis: discordant effects on bone mineral density and fractures? Clin Exp Rheumatol 2003, 21:155–160.

    Google Scholar 

  9. Boers M, Verhoeven AC, Markusse HM, et al.: Randomised comparison of combined step-down prednisolone, methotrexate, and sulfasalazine with sulfasalazine alone in early rheumatoid arthritis. Lancet 1997, 350:309–318.

    Article  PubMed  CAS  Google Scholar 

  10. Bijlsma JW, Boers M, Saag KG, Furst DE: Glucocorticoids in the treatment of early and late R A. Ann Rheum Dis 2003, 62:1033–1037.

    Article  PubMed  CAS  Google Scholar 

  11. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC: Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblast and osteocytes by glucocorticoids. J Clin Invest 1998, 102:274–282.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Raj Nair MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kenneth G. Saag MD, MSc
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nair, R., Saag, K.G. Low- dose prednisolone in early rheumatoid arthritis. Curr Rheumatol Rep 8, 48–49 (2006). https://doi.org/10.1007/s11926-006-0025-3

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11926-006-0025-3

Keywords

Search

Navigation