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Pathogenic role and clinical relevance of antineutrophil cytoplasmic antibodies in vasculitides

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Abstract

Within the last year, a growing body of evidence for a distinct role of antineutrophil cytoplasmic antibodies (ANCA) in the pathogenesis of ANCA-associated vasculitides (AAV) has developed. An experimental model of myeloperoxidase (MPO)-ANCA-associated vasculitis provided direct and convincing in vivo evidence that MPO-ANCA are primary pathogenic factors in small-vessel vasculitis by augmenting of leukocyte-vessel wall interaction and leukocyte-mediated vascular injury. Determination of bacterial lipopolysaccharide (LPS) effects on disease severity in a mouse model of anti-MPO-induced glomerulonephritis showed that ANCA and other proinflammatory stimuli of infectious origin acted in synergism in the development of destructive inflammation.

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Authors and Affiliations

  1. Department of Medicine B & Center for Autoimmune Diseases, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel

    Yehuda Shoenfeld MD, FRCP

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  1. Ora Shovman MD
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  2. Boris Gilburd PhD
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  3. Gisele Zandman-Goddard MD
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  4. Yaniv Sherer MD
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  5. Yehuda Shoenfeld MD, FRCP
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Correspondence to Yehuda Shoenfeld MD, FRCP.

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Shovman, O., Gilburd, B., Zandman-Goddard, G. et al. Pathogenic role and clinical relevance of antineutrophil cytoplasmic antibodies in vasculitides. Curr Rheumatol Rep 8, 292–298 (2006). https://doi.org/10.1007/s11926-006-0012-8

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