Skip to main content
SpringerLink
Log in

Apoptosis and autoimmunity: When apoptotic cells break their silence

  • Invited Commentary
  • Published:
Current Rheumatology Reports Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Savill J: Apoptosis in resolution of inflammation. J Leukoc Biol 1997, 61:375–380.

    PubMed  CAS  Google Scholar 

  2. Voll RE, Herrmann M, Roth EA, et al.: Immunosuppressive effects of apoptotic cells. Nature 1997, 390:350–351.

    Article  PubMed  CAS  Google Scholar 

  3. Fadok VA, Bratton DL, Konowal A, et al.: Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 1998, 101:890–898.

    PubMed  CAS  Google Scholar 

  4. Herrmann M, Voll RE, Zoller OM, et al.: Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998, 41:1241–1250.

    Article  PubMed  CAS  Google Scholar 

  5. Baumann I, Kolowos W, Voll RE, et al.: Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum 2002, 46:191–201.

    Article  PubMed  Google Scholar 

  6. Tan EM, Schur PH, Carr RI, Kunkel HG: Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus. J Clin Invest 1966, 45:1732–1738.

    PubMed  CAS  Google Scholar 

  7. Steinman CR: Circulating DNA in systemic lupus erythematosus. Isolation and characterization. J Clin Invest 1984, 73:832–841.

    Article  PubMed  CAS  Google Scholar 

  8. Herrmann M, Voll RE, Kalden JR: Etiopathogenesis of systemic lupus erythematosus. Immunol Today 2000, 21:424–426.

    Article  PubMed  CAS  Google Scholar 

  9. Lorenz HM, Grunke M, Hieronymus T, et al.: In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum 1997, 40:306–317.

    Article  PubMed  CAS  Google Scholar 

  10. Casciola-Rosen LA, Anhalt G, Rosen A: Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994, 179:1317–1330.

    Article  PubMed  CAS  Google Scholar 

  11. Utz PJ, Anderson P: Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens. Arthritis Rheum 1998, 41:1152–1160.

    Article  PubMed  CAS  Google Scholar 

  12. Pollard KM, Lee DK, Casiano CA, et al.: The autoimmunity- inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular and antigenic properties. J Immunol 1997, 158:3521–3528.

    PubMed  CAS  Google Scholar 

  13. Casiano CA, Tan EM: Recent developments in the understanding of antinuclear autoantibodies. Int Arch Allergy Immunol 1996, 111:308–313.

    Article  PubMed  CAS  Google Scholar 

  14. Rovere P, Sabbadini MG, Fazzini F, et al.: Remnants of suicidal cells fostering systemic autoaggression. Apoptosis in the origin and maintenance of autoimmunity. Arthritis Rheum 2000, 43:1663–1672.

    Article  PubMed  CAS  Google Scholar 

  15. Voll RE, Roth EA, Girkontaite I, et al.: Histone-specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double-stranded DNA antibody production. Arthritis Rheum 1997, 40:2162–2171.

    Article  PubMed  CAS  Google Scholar 

  16. Winkler TH, Fehr H, Kalden JR: Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. Eur J Immunol 1992, 22:1719–1728.

    Article  PubMed  CAS  Google Scholar 

  17. Wellmann U, Letz M, Herrmann M, et al.: The evolution of human anti-double-stranded DNA autoantibodies. Proc Natl Acad Sci U S A 2005, 102:9258–9263.

    Article  PubMed  CAS  Google Scholar 

  18. Gaipl US, Franz S, Voll RE, et al.: Defects in the disposal of dying cells lead to autoimmunity. Curr Rheumatol Rep 2004, 6:401–407.

    PubMed  Google Scholar 

  19. Lauber K, Bohn E, Krober SM, et al.: Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell 2003, 113:717–730.

    Article  PubMed  CAS  Google Scholar 

  20. Hart SP, Smith JR, Dransfield I: Phagocytosis of opsonized apoptotic cells: roles for ‘old fashioned’ receptors for antibody and complement. Clin Exp Immunol 2004, 135:181–185.

    Article  PubMed  CAS  Google Scholar 

  21. Franz S, Frey B, Sheriff A, et al.: Lectins detect changes of the glycosylation status of plasma membrane constituents during late apoptosis. Cytometry A 2006, 69:230–239.

    PubMed  Google Scholar 

  22. Coleman ML, Sahai EA, Yeo M, et al.: Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol 2001, 3:339–345.

    Article  PubMed  CAS  Google Scholar 

  23. Franz S, Frey B, Herrmann K, et al.: Late apoptotic cells expose incompletely processed proteins on their surfaces. Immunobiology 2005, 210:558.

    Google Scholar 

  24. Sheriff A, Gaipl US, Franz S, et al.: Loss of GM1 surface expression precedes annexin V-phycoerythrin binding of neutrophils undergoing spontaneous apoptosis during in vitro aging. Cytometry A 2004, 62:75–80.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine III, Friedrich-Alexander University of Erlangen-Nuremberg, 12, 91054, Krankenhausstr, Erlangen, Germany

    Sandra Franz

Authors
  1. Sandra Franz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Udo S. Gaipl PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Luis E. Munoz MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ahmed Sheriff PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alexandra Beer
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Joachim R. Kalden MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Martin Herrmann MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sandra Franz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Franz, S., Gaipl, U.S., Munoz, L.E. et al. Apoptosis and autoimmunity: When apoptotic cells break their silence. Curr Rheumatol Rep 8, 245–247 (2006). https://doi.org/10.1007/s11926-006-0001-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11926-006-0001-y

Keywords

Search

Navigation