Conclusions
The authors noted significant study limitations to the studies of TCA including lack of trials using standard antidepressant doses, short study duration, lack of adequate measures of mood disorder, and small sample sizes. The authors suggest double-blind, placebo-controlled, parallel-group studies of sufficient sample size and adequate duration. In addition, if agents with antidepressant activities are studied, adequate assessment of mood disorders is critical. Standardized outcome measures, including physical functioning and quality of life, should be included.
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Crofford, L.J. Meta-analysis of antidepressants in fibromyalgia. Curr Rheumatol Rep 3, 172 (2001). https://doi.org/10.1007/s11926-001-0013-6
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DOI: https://doi.org/10.1007/s11926-001-0013-6