Abstract
Purpose of Review
We reviewed recent evidence on the use of electroconvulsive therapy (ECT) in the geriatric population. This review looked at the literature on depression, for which there is a breadth of data, as well as other conditions that have historically not been as well studied, as well as attempting to provide practical recommendations for ECT practitioners. This review also examined the impact of the COVID-19 pandemic on ECT in the elderly.
Recent Findings
ECT shows robust efficacy across many psychiatric diseases, from depression and bipolar disorder to psychosis and catatonia. It has also shown positive results at improving behavioral symptoms of dementia, as well as improving motor symptoms seen in Parkinson’s disease. It is routinely found to be a safe treatment as well, generally with only minimal transient side effects.
Summary
ECT should not be considered a “last-resort” treatment for geriatric patients suffering from psychiatric disorders. It has historical and recent literature supporting its use in many psychiatric disorders and has been shown to be safe with minimal side effects when appropriate considerations are taken for the elderly population.
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References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Berrios GE. The scientific origins of electroconvulsive therapy: a conceptual history. Hist Psychiatry. 1997;8(29):105–19. https://doi.org/10.1177/0957154x9700802908.
Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. The Lancet. 2003;361(9360):799–808. https://doi.org/10.1016/s0140-6736(03)12705-5.
•• Kellner CH, Husain MM, Knapp RG, McCall WV, Petrides G, Rudorfer MV, et al. Right unilateral ultrabrief pulse ECT in geriatric depression: phase 1 of the PRIDE study. Am J Psychiat. 2016;173(11):1101–9. https://doi.org/10.1176/appi.ajp.2016.15081101. Multisite study showing efficacy for RUL-UB ECT plus Venlafaxine for depression in the elderly.
•• Kellner CH, Husain MM, Knapp RG, McCall WV, Petrides G, Rudorfer MV, et al. A novel strategy for continuation ECT in geriatric depression: phase 2 of the PRIDE study. Am J Psychiat. 2016;173(11):1110–8. https://doi.org/10.1176/appi.ajp.2016.16010118. Multisite study showing that additional ECT after attaining remission showed benefit in sustaining improved mood over medication alone.
• Dominiak M, Goetz Z, Antosik-Wojcinska AZ, Swiecicki L. Right unilateral versus bilateral formula-based electroconvulsive therapy in the treatment of major depression in elderly patients: a randomised, open label, pilot controlled trial. Psychogeriatrics. 2021;21(2):175–84. https://doi.org/10.1111/psyg.12652. Randomised controlled trial showing comparable efficacy in RUL and BL treatments, with improved tolerability in the RUL arm.
•• Hermida AP, Glass OM, Shafi H, McDonald WM. Electroconvulsive therapy in depression: current Practice and future direction. Psychiatr Clin North Am. 2018;41(3):341–53. https://doi.org/10.1016/j.psc.2018.04.001. An in-depth review article looking at recent advances in ECT technique, treating those with comorbid medical conditions, and special populations.
Heijnen W, Kamperman AM, Tjokrodipo LD, Hoogendijk WJG, van den Broek WW, Birkenhager TK. Influence of age on ECT efficacy in depression and the mediating role of psychomotor retardation and psychotic features. J Psychiatr Res. 2019;109:41–7. https://doi.org/10.1016/j.jpsychires.2018.11.014.
Riva-Posse P, Hermida AP, McDonald WM. The role of electroconvulsive and neuromodulation therapies in the treatment of geriatric depression. Psychiatr Clin North Am. 2013;36(4):607–30. https://doi.org/10.1016/j.psc.2013.08.007.
Dong M, Zhu XM, Zheng W, Li XH, Ng CH, Ungvari GS, et al. Electroconvulsive therapy for older adult patients with major depressive disorder: a systematic review of randomized controlled trials. Psychogeriatrics. 2018;18(6):468–75. https://doi.org/10.1111/psyg.12359.
Grover S, Satapathy A, Chakrabarti S, Avasthi A. Electroconvulsive therapy among elderly patients: a study from tertiary care centre in north India. Asian J Psychiatr. 2018;31:43–8. https://doi.org/10.1016/j.ajp.2018.01.004.
Singh D, Lee J. Electroconvulsive therapy in an elderly patient with recurrent meningiomas. Aust N Z J Psychiatry. 2018;52(3):291. https://doi.org/10.1177/0004867417739985.
Hermida AP, Job G, Tang Y. Electroconvulsive therapy in a geriatric patient with normal pressure hydrocephalus without a shunt. J ect. 2014;30(4):e55–6. https://doi.org/10.1097/yct.0000000000000188.
Rozing MP, Jørgensen MB, Osler M. Electroconvulsive therapy and later stroke in patients with affective disorders. Br J Psychiatry. 2019;214(3):168–70. https://doi.org/10.1192/bjp.2018.150.
Osler M, Rozing MP, Christensen GT, Andersen PK, Jørgensen MB. Electroconvulsive therapy and risk of dementia in patients with affective disorders: a cohort study. Lancet Psychiatry. 2018;5(4):348–56. https://doi.org/10.1016/s2215-0366(18)30056-7.
Brown SK, Nowlin RB, Sartorelli R, Smith J, Johnson K. Patient experience of electroconvulsive therapy: a retrospective review of clinical outcomes and satisfaction. J ect. 2018;34(4):240–6. https://doi.org/10.1097/yct.0000000000000492.
Takamiya A, Sawada K, Mimura M, Kishimoto T. Attitudes toward electroconvulsive therapy among involuntary and voluntary patients. J ect. 2019;35(3):165–9. https://doi.org/10.1097/yct.0000000000000571.
Rhee TG, Olfson M, Sint K, Wilkinson ST. Characterization of the quality of electroconvulsive therapy among older medicare beneficiaries. J Clin Psychiatry. 2020;81(4). https://doi.org/10.4088/JCP.19m13186.
Neurological devices; reclassification of electroconvulsive therapy devices; effective date of requirement for premarket approval for electroconvulsive therapy devices for certain specified intended uses. Final order. Fed Regist. 2018;83(246):66103–24.
Hermida AP, McDonald WM, Steenland K, Levey A. The association between late-life depression, mild cognitive impairment and dementia: is inflammation the missing link? Expert Rev Neurother. 2012;12(11):1339–50. https://doi.org/10.1586/ern.12.127.
Lisanby SH, McClintock SM, Alexopoulos G, Bailine SH, Bernhardt E, Briggs MC, et al. Neurocognitive effects of combined electroconvulsive therapy (ECT) and Venlafaxine in geriatric depression: Phase 1 of the PRIDE Study. Am J Geriatr Psychiatry. 2020;28(3):304–16. https://doi.org/10.1016/j.jagp.2019.10.003.
Østergaard SD, Speed MS, Kellner CH, Mueller M, McClintock SM, Husain MM, et al. Electroconvulsive therapy (ECT) for moderate-severity major depression among the elderly: Data from the pride study. J Affect Disord. 2020;274:1134–41. https://doi.org/10.1016/j.jad.2020.05.039.
• McCall WV, Lisanby SH, Rosenquist PB, Dooley M, Husain MM, Knapp RG, et al. Effects of continuation electroconvulsive therapy on quality of life in elderly depressed patients: A randomized clinical trial. J Psychiatr Res. 2018;97:65–9. https://doi.org/10.1016/j.jpsychires.2017.11.001. Analysis of PRIDE data showing improved health related quality of life for those in the ECT plus medication maintenance group compared to the medication alone group.
Wagenmakers MJ, Oudega ML, Vansteelandt K, Spaans HP, Verwijk E, Obbels J, et al. Psychotic late-life depression less likely to relapse after electroconvulsive therapy. J Affect Disord. 2020;276:984–90. https://doi.org/10.1016/j.jad.2020.07.039.
Socci C, Medda P, Toni C, Lattanzi L, Tripodi B, Vannucchi G, et al. Electroconvulsive therapy and age: age-related clinical features and effectiveness in treatment resistant major depressive episode. J Affect Disord. 2018;227:627–32. https://doi.org/10.1016/j.jad.2017.11.064.
McCall WV, Lisanby SH, Rosenquist PB, Dooley M, Husain MM, Knapp RG, et al. Effects of a course of right unilateral ultrabrief pulse electroconvulsive therapy combined with Venlafaxine on insomnia symptoms in elderly depressed patients. J Clin Psychiatry. 2018;79(2). https://doi.org/10.4088/JCP.16m11089.
• Parker Schwab P, Dhingra A, Chapman H, Tan AC, McDonald WM, Riva-Posse P, et al. Ultra-brief right unilateral electroconvulsive therapy for the treatment of late-life bipolar disorder. J Affect Disord. 2021;290:197–201. https://doi.org/10.1016/j.jad.2021.04.028. A study showing safety and efficacy of ECT for patients with late life bipolar depression.
Hermida AP. Neuromodulation Therapies and Ketamine in Geriatric Bipolar Disorder. In: Lehmann S, Forester, B, editor. Bipolar Disorder in Older Age Patients. Springer Science; 2017. p. XIV, 238.
Mukherjee S, Sackeim HA, Schnur DB. Electroconvulsive therapy of acute manic episodes: a review of 50 years’ experience. Am J Psychiatry. 1994;151(2):169–76. https://doi.org/10.1176/ajp.151.2.169.
Versiani M, Cheniaux E, Landeira-Fernandez J. Efficacy and safety of electroconvulsive therapy in the treatment of bipolar disorder: a systematic review. J ect. 2011;27(2):153–64. https://doi.org/10.1097/YCT.0b013e3181e6332e.
Small JG, Klapper MH, Kellams JJ, Miller MJ, Milstein V, Sharpley PH, et al. Electroconvulsive treatment compared with lithium in the management of manic states. Arch Gen Psychiatry. 1988;45(8):727–32. https://doi.org/10.1001/archpsyc.1988.01800320037004.
Sikdar S, Kulhara P, Avasthi A, Singh H. Combined chlorpromazine and electroconvulsive therapy in mania. Br J Psychiatry. 1994;164(6):806–10. https://doi.org/10.1192/bjp.164.6.806.
Francis B, Petrus CF, Wong HH. Electroconvulsive therapy in a 91-year old Asian lady with late onset bipolar mania. Asian J Psychiatr. 2020;50: 101986. https://doi.org/10.1016/j.ajp.2020.101986.
Practice guideline for the treatment of patients with bipolar disorder (revision). Am J Psychiatry. 2002;159(4 Suppl):1–50.
Grunze H, Vieta E, Goodwin GM, Bowden C, Licht RW, Moller HJ, et al. The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: update 2009 on the treatment of acute mania. World J Biol Psychiatry. 2009;10(2):85–116. https://doi.org/10.1080/15622970902823202.
Popiolek K, Bejerot S, Brus O, Hammar Å, Landén M, Lundberg J, et al. Electroconvulsive therapy in bipolar depression—effectiveness and prognostic factors. Acta Psychiatr Scand. 2019;140(3):196–204. https://doi.org/10.1111/acps.13075.
Fontenelle LF, Dos Santos-Ribeiro S, Kalaf J, Yücel M. Electroconvulsive therapy for trichotillomania in a bipolar patient. Bull Menninger Clin. 2019;83(1):97–104. https://doi.org/10.1521/bumc.2019.83.1.97.
Ciapparelli A, Dell’Osso L, Tundo A, Pini S, Chiavacci MC, Di Sacco I, et al. Electroconvulsive therapy in medication-nonresponsive patients with mixed mania and bipolar depression. J Clin Psychiatry. 2001;62(7):552–5. https://doi.org/10.4088/jcp.v62n07a09.
Medda P, Perugi G, Zanello S, Ciuffa M, Rizzato S, Cassano GB. Comparative response to electroconvulsive therapy in medication-resistant bipolar I patients with depression and mixed state. J ect. 2010;26(2):82–6. https://doi.org/10.1097/YCT.0b013e3181b00f1e.
Kellner CH, Ahle GM, Geduldig ET. Electroconvulsive therapy for bipolar disorder: evidence supporting what clinicians have long known. J Clin Psychiatry. 2015;76(9):e1151–2. https://doi.org/10.4088/JCP.14com09498.
Strömgren LS. Electroconvulsive therapy in Aarhus, Denmark, in 1984: Its Application in Nondepressive Disorders. Convuls Ther. 1988;4(4):306–13.
Devanand DP, Polanco P, Cruz R, Shah S, Paykina N, Singh K, et al. The efficacy of ECT in mixed affective states. J ect. 2000;16(1):32–7. https://doi.org/10.1097/00124509-200003000-00004.
Faedda GL, Becker I, Baroni A, Tondo L, Aspland E, Koukopoulos A. The origins of electroconvulsive therapy: Prof. Bini's first report on ECT. J Affect Disord. 2010;120(1–3):12–5. https://doi.org/10.1016/j.jad.2009.01.023.
Reinhardt MM, Cohen CI. Late-life psychosis: diagnosis and treatment. Current Psychiatry Reports. 2015;17(2). https://doi.org/10.1007/s11920-014-0542-0.
Petrides G, Fink M, Husain MM, Knapp RG, Rush AJ, Mueller M, et al. ECT remission rates in psychotic versus nonpsychotic depressed patients: a report from CORE. J ect. 2001;17(4):244–53. https://doi.org/10.1097/00124509-200112000-00003.
• Kumagaya DY. Acute electroconvulsive therapy in the elderly with schizophrenia and schizoaffective disorder: a case series. Asia Pac Psychiatry. 2019;11(4):e12361. https://doi.org/10.1111/appy.12361. Retrospective chart review finding that ECT is safe and effective in elderly patients with schizoaffective disorder or schizophrenia who have previously not responded well to medications.
Petrides G, Malur C, Braga RJ, Bailine SH, Schooler NR, Malhotra AK, et al. Electroconvulsive therapy augmentation in Clozapine-resistant schizophrenia: a prospective, randomized study. Am J Psychiatry. 2015;172(1):52–8. https://doi.org/10.1176/appi.ajp.2014.13060787.
Beach SR, Gomez-Bernal F, Huffman JC, Fricchione GL. Alternative treatment strategies for catatonia: A systematic review. Gen Hosp Psychiatry. 2017;48:1–19. https://doi.org/10.1016/j.genhosppsych.2017.06.011.
• Unal A, Altindag A, Demir B, Aksoy I. The use of Lorazepam and electroconvulsive therapy in the treatment of catatonia: treatment characteristics and outcomes in 60 patients. J ect. 2017;33(4):290–3. https://doi.org/10.1097/yct.0000000000000433. A study showing the benefit of ECT for Catatonia should initial treatments with benzodiazepines fail.
Raveendranathan D, Narayanaswamy JC, Reddi SV. Response rate of catatonia to electroconvulsive therapy and its clinical correlates. Eur Arch Psychiatry Clin Neurosci. 2012;262(5):425–30. https://doi.org/10.1007/s00406-011-0285-4.
Meyen R, Acevedo-Diaz EE, Reddy SS. Challenges of managing delirium and catatonia in a medically ill patient. Schizophr Res. 2018;197:557–61. https://doi.org/10.1016/j.schres.2018.02.019.
•• Pritchett CM, Chapman H, Job GP, McDonald WM, Riva-Posse P, Tan A, et al. The effectiveness of Ultrabrief Right Unilateral ECT for the treatment of Catatonia. J Ect. 2020;36(3):e36-e42. A case series showing benefit and tolerability of RUL-UB ECT for Catatonia, especially for those who may require maintenance ECT.
Wittenauer Welsh J, Janjua AU, Garlow SJ, McCormick L, Husain MM, Maixner DF, et al. Use of expert consultation in a complex case of neuroleptic malignant syndrome requiring electroconvulsive therapy. J Psychiatr Pract. 2016;22(6):484–9. https://doi.org/10.1097/pra.0000000000000193.
Davis JM, Janicak PG, Sakkas P, Gilmore C, Wang Z. Electroconvulsive therapy in the treatment of the neuroleptic malignant syndrome. Convuls Ther. 1991;7(2):111–20.
Strawn JR, Keck PE, Caroff SN. Neuroleptic Malignant Syndrome. Am J Psychiatry. 2007;164(6):870–6. https://doi.org/10.1176/ajp.2007.164.6.870.
Trollor JN, Sachdev PS. Electroconvulsive treatment of neuroleptic malignant syndrome: a review and report of cases. Aust N Z J Psychiatry. 1999;33(5):650–9. https://doi.org/10.1080/j.1440-1614.1999.00630.x.
Hanin B, Lerner Y. Neuroleptic malignant syndrome: neuroleptic rechallenge after electroconvulsive therapy. Convuls Ther. 1993;9(3):198–204.
Brodaty H, Draper B, Saab D, Low LF, Richards V, Paton H, et al. Psychosis, depression and behavioural disturbances in Sydney nursing home residents: prevalence and predictors. Int J Geriatr Psychiatry. 2001;16(5):504–12. https://doi.org/10.1002/gps.382.
Jeste DV, Blazer D, Casey D, Meeks T, Salzman C, Schneider L, et al. ACNP White paper: update on use of antipsychotic drugs in elderly persons with dementia. Neuropsychopharmacology. 2008;33(5):957–70. https://doi.org/10.1038/sj.npp.1301492.
Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JC. Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging. Am J Psychiatry. 2000;157(5):708–14. https://doi.org/10.1176/appi.ajp.157.5.708.
Walsh JS, Welch HG, Larson EB. Survival of outpatients with Alzheimer-type dementia. Ann Intern Med. 1990;113(6):429–34. https://doi.org/10.7326/0003-4819-113-6-429.
Ballard C, Corbett A. Agitation and aggression in people with Alzheimer’s disease. Curr Opin Psychiatry. 2013;26(3):252–9. https://doi.org/10.1097/YCO.0b013e32835f414b.
Sultzer DL, Davis SM, Tariot PN, Dagerman KS, Lebowitz BD, Lyketsos CG, et al. Clinical symptom responses to atypical antipsychotic medications in Alzheimer’s disease: phase 1 outcomes from the CATIE-AD effectiveness trial. Am J Psychiatry. 2008;165(7):844–54. https://doi.org/10.1176/appi.ajp.2008.07111779.
•• Glass OM, Forester BP, Hermida AP. Electroconvulsive therapy (ECT) for treating agitation in dementia (major neurocognitive disorder)—a promising option. Int Psychogeriatr. 2017;29(5):717–26. https://doi.org/10.1017/s1041610216002258. A literature review showing benefit of ECT for patients with agitation in dementia, especially for those who have failed medications and who may require maintenance treatment.
•• Hermida AP, Tang YL, Glass O, Janjua AU, McDonald WM. Efficacy and safety of ECT for behavioral and psychological symptoms of dementia (BPSD): a retrospective chart review. Am J Geriatr Psychiatry. 2020;28(2):157–63. https://doi.org/10.1016/j.jagp.2019.09.008. A study showing that in patients with behavioral and psychological symptoms of dementia, ECT is efficacious, safe, and tolerated well. It also may lead to fewer psychotropics being prescribed and an increase in overall level of function.
Johari N, Glue P, Barak Y. Screaming behaviour in response to electroconvulsive treatment: psychogeriatric note on a patient with Alzheimer’s disease. Psychogeriatrics. 2019;19(6):626–7. https://doi.org/10.1111/psyg.12443.
van den Berg JF, Kruithof HC, Kok RM, Verwijk E, Spaans HP. Electroconvulsive therapy for agitation and aggression in dementia: a systematic review. Am J Geriatr Psychiatry. 2018;26(4):419–34. https://doi.org/10.1016/j.jagp.2017.09.023.
• Isserles M, Daskalakis ZJ, Kumar S, Rajji TK, Blumberger DM. Clinical effectiveness and tolerability of electroconvulsive therapy in patients with neuropsychiatric symptoms of dementia. J Alzheimers Dis. 2017;57(1):45–51. https://doi.org/10.3233/jad-161000. A study finding that ECT is effective in treating the neuropsychiatric symptoms of dementia, as well as sustaining a response if patients received maintenance ECT.
Acharya D, Harper DG, Achtyes ED, Seiner SJ, Mahdasian JA, Nykamp LJ, et al. Safety and utility of acute electroconvulsive therapy for agitation and aggression in dementia. Int J Geriatr Psychiatry. 2015;30(3):265–73. https://doi.org/10.1002/gps.4137.
Izuhara M, Hashioka S, Sato T, Nishikoori H, Koike M, Matsuda H, et al. The effectiveness of electroconvulsive therapy for psychiatric symptoms and cognitive fluctuations similar to dementia with Lewy bodies: a case report. Psychogeriatrics. 2020;20(2):229–31. https://doi.org/10.1111/psyg.12465.
Dhingra A, Janjua AU, Hack L, Waserstein G, Palanci J, Hermida AP. Exploring nonmotor neuropsychiatric manifestations of parkinson disease in a comprehensive care setting. J Geriatr Psychiatry Neurol. 2021;34(3):181–95. https://doi.org/10.1177/0891988720915525.
Kennedy R, Mittal D, O’Jile J. Electroconvulsive therapy in movement disorders: an update. J Neuropsychiatry Clin Neurosci. 2003;15(4):407–21. https://doi.org/10.1176/jnp.15.4.407.
Klok MP, Nonnekes J, Stek ML, Bloem BR, Rhebergen D. Freezing of gait and major depressive disorder responding both to electroconvulsive therapy. Parkinsonism Relat Disord. 2019;66:249–50. https://doi.org/10.1016/j.parkreldis.2019.07.002.
Wilkins KM, Ostroff R, Tampi RR. Efficacy of electroconvulsive therapy in the treatment of nondepressed psychiatric illness in elderly patients: a review of the literature. J Geriatr Psychiatry Neurol. 2008;21(1):3–11. https://doi.org/10.1177/0891988707311027.
Andersen K, Balldin J, Gottfries CG, Granérus AK, Modigh K, Svennerholm L, et al. A double-blind evaluation of electroconvulsive therapy in Parkinson’s disease with “on-off” phenomena. Acta Neurol Scand. 1987;76(3):191–9. https://doi.org/10.1111/j.1600-0404.1987.tb03566.x.
Fochtmann L. A Mechanism for the efficacy of ECT in Parkinson’s disease. Convuls Ther. 1988;4(4):321–7.
Practice guideline for the treatment of patients with delirium. American Psychiatric Association. Am J Psychiatry. 1999;156(5 Suppl):1–20.
• Nielsen RM, Olsen KS, Lauritsen AO, Boesen HC. Electroconvulsive therapy as a treatment for protracted refractory delirium in the intensive care unit—five cases and a review. J Crit Care. 2014;29(5):881.e1–6. https://doi.org/10.1016/j.jcrc.2014.05.012. A case series of 5 patients with prolonged severe ICU delirium who responded to ECT after failing multiple medication trials.
Hassamal S, Pandurangi A, Venkatachalam V, Levenson J. Delayed onset and prolonged ECT-related delirium. Case Rep Psychiatry. 2013;2013: 840425. https://doi.org/10.1155/2013/840425.
Fink M. ECT in delirious states. J ect. 1999;15(3):175–7.
Charlton BG. The “anti-delirium” theory of electroconvulsive therapy action. Med Hypotheses. 1999;52(6):609–11. https://doi.org/10.1054/mehy.1999.0857.
Kramp P, Bolwig TG. Electroconvulsive therapy in acute delirious states. Compr Psychiatry. 1981;22(4):368–71. https://doi.org/10.1016/0010-440x(81)90020-1.
Bouckaert F, Emsell L, Vansteelandt K, De Winter FL, Van den Stock J, Obbels J, et al. Electroconvulsive therapy response in late-life depression unaffected by age-related brain changes. J Affect Disord. 2019;251:114–20. https://doi.org/10.1016/j.jad.2019.03.055.
Carlier A, Berkhof JG, Rozing M, Bouckaert F, Sienaert P, Eikelenboom P, et al. Inflammation and remission in older patients with depression treated with electroconvulsive therapy; findings from the MODECT study(✰). J Affect Disord. 2019;256:509–16. https://doi.org/10.1016/j.jad.2019.06.040.
Carlier A, Boers K, Veerhuis R, Bouckaert F, Sienaert P, Eikelenboom P, et al. S100 calcium-binding protein B in older patients with depression treated with electroconvulsive therapy. Psychoneuroendocrinology. 2019;110: 104414. https://doi.org/10.1016/j.psyneuen.2019.104414.
• Jurek L, Dorey JM, Nourredine M, Galvao F, Brunelin J. Impact of vascular risk factors on clinical outcome in elderly patients with depression receiving electroconvulsive therapy. J Affect Disord. 2021;279:308–15. https://doi.org/10.1016/j.jad.2020.10.025. A study that found that in patients with late life depression, those with more vascular risk factors had less of a response to ECT than those with fewer vascular risk factors. This may be a predictable variable to identify those with greater likelihood for response prior to ECT.
Maixner DF, Weiner R, Reti IM, Hermida AP, Husain MM, Larsen D, et al. Electroconvulsive therapy is an essential procedure. Am J Psychiatry. 2021;178(5):381–2. https://doi.org/10.1176/appi.ajp.2020.20111647.
Burhan AM, Safi A, Blair M, O’Reilly R. Electroconvulsive therapy for geriatric depression in the COVID-19 era: reflection on the ethics. Am J Geriatr Psychiatry. 2020;28(8):900–2. https://doi.org/10.1016/j.jagp.2020.05.007.
Lapid MI, Seiner S, Heintz H, Hermida AP, Nykamp L, Sanghani SN, et al. Electroconvulsive therapy practice changes in older individuals due to COVID-19: expert consensus statement. Am J Geriatr Psychiatry. 2020;28(11):1133–45. https://doi.org/10.1016/j.jagp.2020.08.001.
Sterina E, Hermida AP, Gerberi DJ, Lapid MI. Emotional resilience of older adults during COVID-19: a systematic review of studies of stress and well-being. Clinical Gerontologist. 2021:1–16. https://doi.org/10.1080/07317115.2021.1928355.
Jørgensen MB, Rozing MP, Kellner CH, Osler M. Electroconvulsive therapy, depression severity and mortality: data from the Danish National Patient Registry. J Psychopharmacol. 2020;34(3):273–9. https://doi.org/10.1177/0269881119895518.
Obbels J, Verwijk E, Vansteelandt K, Dols A, Bouckaert F, Schouws S, et al. Long-term neurocognitive functioning after electroconvulsive therapy in patients with late-life depression. Acta Psychiatr Scand. 2018;138(3):223–31. https://doi.org/10.1111/acps.12942.
•• Obbels J, Vansteelandt K, Verwijk E, Dols A, Bouckaert F, Oudega ML, et al. MMSE changes during and after ECT in late-life depression: a prospective study. Am J Geriatr Psychiatry. 2019;27(9):934–44. https://doi.org/10.1016/j.jagp.2019.04.006. A study looking at patients with late life depression treated with ECT which found overall improvement in MMSE scores during and up to 6 months after ECT treatments.
Bryson EO, Aloysi AS, Farber KG, Kellner CH. Individualized anesthetic management for patients undergoing electroconvulsive therapy: a review of current practice. Anesth Analg. 2017;124(6):1943–56. https://doi.org/10.1213/ane.0000000000001873.
•• Hermida AP, Janjua AU, Tang Y, Syre SR, Job G, McDonald WM. Use of orally disintegrating Olanzapine during electroconvulsive therapy for prevention of postictal agitation. J Psychiatr Pract. 2016;22(6):459–62. https://doi.org/10.1097/pra.0000000000000185. A study looking at the prophylactic use of orally disintegrating olanzapine given prior to ECT treatments for post ictal agitation. It found that this was a very efficacious treatment in reducing the incidence of post ictal agitation.
•• Hermida AP, Goldstein FC, Loring DW, McClintock SM, Weiner RD, Reti IM, et al. ElectroConvulsive therapy Cognitive Assessment (ECCA) tool: A new instrument to monitor cognitive function in patients undergoing ECT. J Affect Disord. 2020;269:36–42. https://doi.org/10.1016/j.jad.2020.03.010. A newly developed tool for monitoring cognitive changes during ECT which looks at cognitive domains known to be affected by ECT that are not tested for in commonly used cognitive tests such as the MoCA or MMSE.
Loo CK, Katalinic N, Martin D, Schweitzer I. A review of ultrabrief pulse width electroconvulsive therapy. Therapeutic Advances in Chronic Disease. 2012;3(2):69–85. https://doi.org/10.1177/2040622311432493.
Sackeim HA, Prudic J, Nobler MS, Fitzsimons L, Lisanby SH, Payne N, et al. Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. Brain Stimul. 2008;1(2):71–83. https://doi.org/10.1016/j.brs.2008.03.001.
Joseph RG, Narayanan M. A case of right unilateral ultra-brief ECT in refractory mania with in situ cranial metallic object. Australas Psychiatry. 2020;28(3):364. https://doi.org/10.1177/1039856220927929.
Williams NR, Bentzley BS, Sahlem GL, Pannu J, Korte JE, Revuelta G, et al. Unilateral ultra-brief pulse electroconvulsive therapy for depression in Parkinson’s disease. Acta Neurol Scand. 2017;135(4):407–11. https://doi.org/10.1111/ane.12614.
Rhoads JC, Votolato NA, Young JL, Gilchrist RH. The successful use of right unilateral ultra-brief pulse electroconvulsive therapy in an adolescent with catatonia. Brain Stimul. 2010;3(1):51–3. https://doi.org/10.1016/j.brs.2009.07.003.
•• Jones KC, Salemi JL, Dongarwar D, Kunik ME, Rodriguez SM, Quach TH, et al. Racial/ethnic disparities in receipt of electroconvulsive therapy for elderly patients with a principal diagnosis of depression in inpatient settings. Am J Geriatr Psychiatry. 2019;27(3):266–78. https://doi.org/10.1016/j.jagp.2018.11.007. A recent study showing racial disparities in those receiving treatment with ECT.
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Anthony N. Chatham, Hadia Shafi, and Adriana P. Hermida declare that they have no conflict of interest.
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Chatham, A.N., Shafi, H. & Hermida, A.P. The Use of ECT in the Elderly—Looking Beyond Depression. Curr Psychiatry Rep 24, 451–461 (2022). https://doi.org/10.1007/s11920-022-01353-0
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DOI: https://doi.org/10.1007/s11920-022-01353-0