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Course of Illness and Treatment Updates for Bipolar Disorder in the Perinatal Period

  • Reproductive Psychiatry and Women's Health (L Hantsoo and S Nagle-Yang, Section Editors)
  • Published:
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Abstract

Purpose of Review

The perinatal period is a time of increased vulnerability for people with bipolar disorder (BD). The purpose of this review is to provide an update of the literature from the last 3 years regarding course of illness and treatments for BD in the perinatal period to guide clinical care.

Recent Findings

Postpartum manic and depressive episodes are emerging as having a unique presentation that may differentiate them from non-perinatal mood episodes. Many important updates regarding medication treatment in the perinatal period have been published recently that have considered the risks of untreated illness versus treatment risks in this population.’

Summary

Despite significant research, there are still gaps in knowledge regarding safety and efficacy of medications for the mother and child. Crucial future areas of study include improved screening guidelines, randomized controlled trials examining medication safety in pregnancy and lactation, and efficacy of nonpharmacologic treatments.

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      Funding

      Dr. Batt is receiving funding from the Hearst Foundation. Dr. Olsavsky is receiving funding from the Developmental Psychobiology Endowment Fund (University of Colorado), American Academy of Child and Adolescent Psychiatry Pilot Award, the National Institute of Mental Health Loan Repayment Program, and the National Institute on Drug Abuse/American Academy of Child and Adolescent Psychiatry K12 Career Development Award (K12DA000357 – PI Gray).

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      Authors and Affiliations

      1. Department of Psychiatry, University of Colorado School of Medicine – Anschutz Medical Campus, Aurora, CO, USA

        Melissa M. Batt, Shaleah Dardar & Celeste St. John-Larkin

      2. Helen and Arthur E. Johnson Depression Center, University of Colorado School of Medicine – Anschutz Medical Campus, 13199 East Montview Blvd, Suite 330, Aurora, CO, 80045, USA

        Melissa M. Batt

      3. Departments of Psychiatry and Obstetrics/Gynecology, University of Colorado School of Medicine – Anschutz Medical Campus, Aurora, CO, USA

        Aviva K. Olsavsky

      4. Department of Biostatistics & Informatics, CO School of Public Health – Anschutz Medical Campus, Aurora, CO, USA

        Rachel L. Johnson & Mary D. Sammel

      5. Children’s Hospital Colorado, Aurora, CO, USA

        Melissa M. Batt, Aviva K. Olsavsky, Shaleah Dardar & Celeste St. John-Larkin

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      Correspondence to Melissa M. Batt.

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      Dr. Olsavsky’s spouse is employed by Thermo Fisher Scientific.

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      Batt, M.M., Olsavsky, A.K., Dardar, S. et al. Course of Illness and Treatment Updates for Bipolar Disorder in the Perinatal Period. Curr Psychiatry Rep 24, 111–120 (2022). https://doi.org/10.1007/s11920-022-01323-6

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