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New Antipsychotic Medications in the Last Decade

  • Schizophrenia and Other Psychotic Disorders (AK Pandurangi, Section Editor)
  • Published:
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Abstract

Purpose of Review

Over the last ten years, the treatment of psychosis has seen a near explosion of creative development in both novel agents and new delivery modalities. The current review summarizes these developments over the past decade (2011–2020). We performed a systematic review utilizing PubMed and PsychInfo with the aim of identifying all the RCT and related analyses in adults with psychosis (schizophrenia and mania).

Recent Findings

We identified 11 significant developments: the introduction of new antipsychotics cariprazine, brexpiprazole, lumateperone, and pimavanserin; introduction of new delivery methods: subcutaneous long-acting risperidone, aripiprazole lauroxil, transdermal asenapine, and inhaled loxapine; and the introduction of new approaches such as olanzapine/samidorphan for olanzapine-associated weight gain, examination of the TAAR1 agonist SEP 363,856 as a test of concept, and the combination of Xanomeline/Trospium, an M1 and M4 muscarinic receptor agonist in conjunction with a peripheral anticholinergic.

Summary

Last decade has seen a tremendous development in second-generation antipsychotics which provides unprecedented treatment options for clinicians in treating psychosis.

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PRISMA mandates that multiple individuals review the same material, and all coauthors served as alternate reviewers. Each author was responsible for the primary review of several agents. Additionally, Mehak Pahwa and Rif S. El Mallakh were instrumental in the overall organization, Ahmad Sleem and Omar H. Elsayed for the organization of the tables, and Mehak Pahwa and Megan Elizabeth Good for writing the final discussion. Dr. El Mallakh was responsible for all aspects of the review.

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Correspondence to Mehak Pahwa or Rif S. El-Mallakh.

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Dr. El Mallakh is a speaker for Eisai, Indivior, Intra-Cellular Therapies, Janssen, Lundbeck, Noven, Otsuka, Sunovion, and Teva. None of the other authors have any potential conflicts of interest to declare.

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Pahwa, M., Sleem, A., Elsayed, O.H. et al. New Antipsychotic Medications in the Last Decade. Curr Psychiatry Rep 23, 87 (2021). https://doi.org/10.1007/s11920-021-01298-w

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