Abstract
Infertility and perinatal loss are common, and associated with lower quality of life, marital discord, complicated grief, major depressive disorder, anxiety disorders, and post-traumatic stress disorder. Young women, who lack social supports, have experienced recurrent pregnancy loss or a history of trauma and / or preexisting psychiatric illness are at a higher risk of experiencing psychiatric illnesses or symptoms after a perinatal loss or during infertility. It is especially important to detect, assess, and treat depression, anxiety, or other psychiatric symptoms because infertility or perinatal loss may be caused or perpetuated by such symptoms. Screening, psychoeducation, provision of resources and referrals, and an opportunity to discuss their loss and plan for future pregnancies can facilitate addressing mental health concerns that arise. Women at risk of or who are currently experiencing psychiatric symptoms should receive a comprehensive treatment plan that includes the following: (1) proactive clinical monitoring, (2) evidence-based approaches to psychotherapy, and (3) discussion of risks, benefits, and alternatives of medication treatment during preconception and pregnancy.
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Evers JLH. Female subfertility. Lancet. 2002;360(9327):151–9. doi:10.1016/S0140-6736(02)09417-5.
Boivin J, Bunting L, Collins JA, Nygren KG. International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Hum Reprod. 2007;22(6):1506–12.
Wischmann TH. Psychogenic infertility—myths and facts. J Assist Reprod Genet. 2003;20(12):485–94.
Romano GA, Ravid H, Zaig I, Schreiber S, Azem F, Shachar I, et al. The psychological profile and affective response of women diagnosed with unexplained infertility undergoing in vitro fertilization. Arch Women Mental Health. 2012;15(6):403–11.
Freeman MP, Toth TL, Cohen LS. Assisted reproduction and risk of depressive relapse: considerations for treatment. Ann Clin Psychiatry. 2013;25(4):283–8. A case-based discussion of the importance of individualized treatment plans for women undergoing ART.
Li X, Knox A, O'byrne K. Corticotrophin-releasing factor and stress-induced inhibition of the gonadotrophin-releasing hormone pulse generator in the female. Brain Res. 2010;1364:153–63.
Chachamovich JR, Chachamovich E, Ezer H, Fleck MP, Knauth D, Passos EP. Investigating quality of life and health-related quality of life in infertility: a systematic review. J Psychosom Obstet Gynecol. 2010;31(2):101–10.
Matthiesen S, Frederiksen Y, Ingerslev HJ, Zachariae R. Stress, distress and outcome of assisted reproductive technology (ART): a meta-analysis. Hum Reprod. 2011;26(10):2763–76.
Boivin J, Griffiths E, Venetis C. Emotional distress in infertile women and failure of assisted reproductive technologies: meta-analysis of prospective psychosocial studies. BMJ. 2011;342:d223.
Zaig I, Azem F, Schreiber S, Gottlieb-Litvin Y, Meiboom H, Bloch M. Women’s psychological profile and psychiatric diagnoses and the outcome of in vitro fertilization: is there an association? Arch Women Mental Health. 2012;15(5):353–9.
Wirtberg I, Möller A, Hogström L, Tronstad S-E, Lalos A. Life 20 years after unsuccessful infertility treatment. Hum Reprod. 2007;22(2):598–604.
Greil AL, McQuillan J, Lowry M, Shreffler KM. Infertility treatment and fertility-specific distress: a longitudinal analysis of a population-based sample of US women. Soc Sci Med. 2011;73(1):87–94.
Beckmann CRB. Obstetrics and gynecology. Lippincott Williams & Wilkins,, Philadelphia, PA. 2006. Table of contents http://catdir.loc.gov/catdir/enhancements/fy0811/2005029418-t.html. Publisher description http://catdir.loc.gov/catdir/enhancements/fy0712/2005029418-d.html.
Stanford JB, White GL, Hatasaka H. Timing intercourse to achieve pregnancy: current evidence. Obstet Gynecol. 2002;100(6):1333–41.
Greil AL, Shreffler KM, Schmidt L, McQuillan J. Variation in distress among women with infertility: evidence from a population-based sample. Hum Reprod. 2011;26(8):2101–12.
Lewis AM, Liu D, Stuart SP, Ryan G. Less depressed or less forthcoming? Self-report of depression symptoms in women preparing for in vitro fertilization. Arch Women Mental Health. 2013;16(2):87–92.
Chen TH, Chang SP, Tsai CF, Juang KD. Prevalence of depressive and anxiety disorders in an assisted reproductive technique clinic. Hum Reprod. 2004;19(10):2313–8. doi:10.1093/humrep/deh414.
Volgsten H, Skoog Svanberg A, Ekselius L, Lundkvist Ö, Sundström Poromaa I. Prevalence of psychiatric disorders in infertile women and men undergoing in vitro fertilization treatment. Hum Reprod. 2008;23(9):2056–63. doi:10.1093/humrep/den154.
Holley SR, Pasch LA, Bleil ME, Gregorich S, Katz PK, Adler NE. Prevalence and predictors of major depressive disorder for fertility treatment patients and their partners. Fertil Steril. 2015;103(5):1332–9. doi:10.1016/j.fertnstert.2015.02.018.
Rockliff HE, Lightman SL, Rhidian E, Buchanan H, Gordon U, Vedhara K. A systematic review of psychosocial factors associated with emotional adjustment in in vitro fertilization patients. Hum Reprod Update. 2014;20(4):594–613.
McQuillan J, Greil AL, White L, Jacob MC. Frustrated fertility: infertility and psychological distress among women. J Marriage Fam. 2003;65(4):1007–18.
Biringer E, Howard LM, Kessler U, Stewart R, Mykletun A. Is infertility really associated with higher levels of mental distress in the female population? Results from the North-Trøndelag Health Study and the Medical Birth Registry of Norway. J Psychosom Obstet Gynecol. 2015;36:38–45. A large registry-based longitudinal study found that unresolved infertility was less burdensome at the population level than in infertility clinics.
Hammarberg K, Fisher JR, Wynter KH. Psychological and social aspects of pregnancy, childbirth and early parenting after assisted conception: a systematic review. Hum Reprod Update. 2008;14(5):395–414. doi:10.1093/humupd/dmn030.
Munk-Olsen T, Agerbo E. Does childbirth cause psychiatric disorders? A population-based study paralleling a natural experiment. Epidemiology. 2015;26(1):79–84. doi:10.1097/ede.0000000000000193.
Marci R, Graziano A, Piva I, Monte GL, Soave I, Giugliano E, et al. Procreative sex in infertile couples: the decay of pleasure? Health Qual Life Outcomes. 2012;10(1):140–7.
Huppelschoten AG, van Dongen AJ, Verhaak CM, Smeenk JM, Kremer JA, Nelen WL. Differences in quality of life and emotional status between infertile women and their partners. Hum Reprod. 2013;28(8):2168–76. doi:10.1093/humrep/det239.
Fisher JR, Baker GH, Hammarberg K. Long-term health, well-being, life satisfaction, and attitudes toward parenthood in men diagnosed as infertile: challenges to gender stereotypes and implications for practice. Fertil Steril. 2010;94(2):574–80. doi:10.1016/j.fertnstert.2009.01.165.
Fisher JR, Hammarberg K. Psychological and social aspects of infertility in men: an overview of the evidence and implications for psychologically informed clinical care and future research. Asia J Androl. 2012;14(1):121–9. doi:10.1038/aja.2011.72.
Schanz S, Reimer T, Eichner M, Hautzinger M, Häfner H-M, Fierlbeck G. Long-term life and partnership satisfaction in infertile patients: a 5-year longitudinal study. Fertil Steril. 2011;96(2):416–21.
Verhaak CM, Lintsen AME, Evers AWM, Braat DDM. Who is at risk of emotional problems and how do you know? Screening of women going for IVF treatment. Hum Reprod. 2010;25(5):1234–40. doi:10.1093/humrep/deq054.
Oron G, Allnutt E, Lackman T, Sokal-Arnon T, Holzer H, Takefman J. A prospective study using Hatha Yoga for stress reduction among women waiting for IVF treatment. Reprod Biomed Online. 2015;30(5):542–8.
Bailey S, Bailey C, Boivin J, Cheong Y, Reading I, Macklon N. A feasibility study for a randomised controlled trial of the positive reappraisal coping intervention, a novel supportive technique for recurrent miscarriage. BMJ Open. 2015;5(4):e007322. doi:10.1136/bmjopen-2014-007322.
de Liz TM, Strauss B. Differential efficacy of group and individual/couple psychotherapy with infertile patients. Hum Reprod. 2005;20(5):1324–32. doi:10.1093/humrep/deh743.
Frederiksen Y, Farver-Vestergaard I, Skovgård NG, Ingerslev HJ, Zachariae R. Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men: a systematic review and meta-analysis. BMJ Open. 2015;5(1):e006592. Systematic review and meta-analysis of 39 studies reports that cognitive behavior therapy and mind body interventions can reduce psychological distress and improve fertility rates.
Boivin J. A review of psychosocial interventions in infertility. Soc Sci Med. 2003;57(12):2325–41.
Friedman BE, Rogers JL, Shahine LK, Westphal LM, Lathi RB. Effect of selective serotonin reuptake inhibitors on in vitro fertilization outcome. Fertil Steril. 2009;92(4):1312–4. doi:10.1016/j.fertnstert.2009.03.060.
Gotlib IH, Whiffen VE, Wallace PM, Mount JH. Prospective investigation of postpartum depression: factors involved in onset and recovery. J Abnorm Psychol. 1991;100(2):122–32.
Cripe SM, Frederick IO, Qiu C, Williams MA. Risk of preterm delivery and hypertensive disorders of pregnancy in relation to maternal co-morbid mood and migraine disorders during pregnancy. Paediatr Perinat Epidemiol. 2011;25(2):116–23. doi:10.1111/j.1365-3016.2010.01182.x.
Byatt N, Deligiannidis KM, Freeman MP. Antidepressant use in pregnancy: a critical review focused on risks and controversies. Acta Psychiatr Scand. 2013;127(2):94–114. Summarizes findings of studies of risks of antidepressants in pregnancy and provides guidance for translating these findings into clinical practice.
Grote NK, Bridge JA, Gavin AR, Melville JL, Iyengar S, Katon WJ. A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. Arch Gen Psychiatry. 2010;67(10):1012–24.
Forman DR, Hara MW, Stuart S, Gorman LL, Larsen KE, Coy KC. Effective treatment for postpartum depression is not sufficient to improve the developing mother-child relationship. Dev Psychopathol. 2007;19(2):585–602. doi:10.1017/S0954579407070289.
Britton JR. Infant temperament and maternal anxiety and depressed mood in the early postpartum period. Women Health. 2011;51(1):55–71.
Yonkers KA, Gotman N, Smith MV, Forray A, Belanger K, Brunetto WL, et al. Does antidepressant use attenuate the risk of a major depressive episode in pregnancy? Epidemiology. 2011;22(6):848–54. doi:10.1097/EDE.0b013e3182306847.
Cohen LS, Altshuler LL, Harlow BL, Nonacs R, Newport DJ, Viguera AC, et al. Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment. JAMA. 2006;295(5):499–507.
Grigoriadis S, VonderPorten EH, Mamisashvili L, Roerecke M, Rehm J, Dennis C-L, et al. Antidepressant exposure during pregnancy and congenital malformations: is there an association? A systematic review and meta-analysis of the best evidence. J Clin Psychiatry. 2013;74(4):e293–308.
Ross LE, Grigoriadis S, Mamisashvili L, VonderPorten EH, Roerecke M, Rehm J, et al. Selected pregnancy and delivery outcomes after exposure to antidepressant medication: a systematic review and meta-analysis. JAMA Psychiatry. 2013;70(4):436–43.
Sockol LE, Epperson CN, Barber JP. A meta-analysis of treatments for perinatal depression. Clin Psychol Rev. 2011;31(5):839–49. doi:10.1016/j.cpr.2011.03.009.
Fledderjohann J. ‘Zero is not good for me’: implications of infertility in Ghana. Hum Reprod. 2012;27(5):1383–90.
Psaros C, Freeman M, Safren SA, Barsky M, Cohen LS. Discontinuation of antidepressants during attempts to conceive: a pilot trial of cognitive behavioral therapy for the prevention of recurrent depression. J Clin Psychopharmacol. 2014;34(4):455–60. doi:10.1097/jcp.0000000000000158.
Griebel CP, Halvorsen J, Golemon TB, Day AA. Management of spontaneous abortion. Am Fam Physician. 2005;72(7):1243–50.
Andersen A-MN, Wohlfahrt J, Christens P, Olsen J, Melbye M. Maternal age and fetal loss: population based register linkage study. BMJ. 2000;320(7251):1708–12.
Kolte AM, Bernardi LA, Christiansen OB, Quenby S, Farquharson RG, Goddijn M, et al. Terminology for pregnancy loss prior to viability: a consensus statement from the ESHRE early pregnancy special interest group. Hum Reprod. 2015;30(3):495–8. doi:10.1093/humrep/deu299.
Kolte AM, van Oppenraaij RH, Quenby S, Farquharson RG, Stephenson M, Goddijn M, et al. Non-visualized pregnancy losses are prognostically important for unexplained recurrent miscarriage. Hum Reprod. 2014;29(5):931–7. doi:10.1093/humrep/deu042.
Zhang X, Kramer MS. Temporal trends in stillbirth in the United States, 1992–2004: a population-based cohort study. BJOG. 2014;121(10):1229–36. doi:10.1111/1471-0528.12883.
Barfield WD, Fetus tCo, Newborn. Standard terminology for fetal, infant, and perinatal deaths. Pediatrics. 2011;128(1):177–81. doi:10.1542/peds.2011-1037.
Gregory E, MacDorman MF, Martin JA. Trends in fetal and perinatal mortality in the United States, 2006–2012. NCHS Data Brief. 2014;169:1–8.
Osterman MJ, Kochanek KD, MacDorman MF, Strobino DM, Guyer B. Annual summary of vital statistics: 2012–2013. Pediatrics. 2015:peds. 2015–0434.
Bicking Kinsey C, Baptiste-Roberts K, Zhu J, Kjerulff KH. Effect of miscarriage history on maternal-infant bonding during the first year postpartum in the first baby study: a longitudinal cohort study. BMC Womens Health. 2014;14:83. doi:10.1186/1472-6874-14-83.
Leon IG. The invisible loss: the impact of perinatal death on siblings. J Psychosom Obstet Gynecol. 1986;5(1):1–14. doi:10.3109/01674828609016738.
Brier N. Grief following miscarriage: a comprehensive review of the literature. J Women Health. 2008;17(3):451–64. doi:10.1089/jwh.2007.0505.
Janssen HJ, Cuisinier MC, de Graauw KP, Hoogduin KA. A prospective study of risk factors predicting grief intensity following pregnancy loss. Arch Gen Psychiatry. 1997;54(1):56–61.
Kersting A, Brähler E, Glaesmer H, Wagner B. Prevalence of complicated grief in a representative population-based sample. J Affect Disord. 2011;131(1):339–43.
Mulvihill A, Walsh T. Pregnancy loss in rural Ireland: an experience of disenfranchised grief. Br J Soc Work. 2013. doi:10.1093/bjsw/bct078.
Maguire M, Light A, Kuppermann M, Dalton VK, Steinauer JE, Kerns JL. Grief after second-trimester termination for fetal anomaly: a qualitative study. Contraception. 2015;91(3):234–9. doi:10.1016/j.contraception.2014.11.015.
Kersting A, Wagner B. Complicated grief after perinatal loss. Dialogues Clin Neurosci. 2012;14(2):187.
van den Akker OB. The psychological and social consequences of miscarriage. Exp Rev Obstet Gynecol. 2011;6(3):1–10.
Richards J, Graham R, Embleton ND, Campbell C, Rankin J. Mothers’ perspectives on the perinatal loss of a co-twin: a qualitative study. BMC Pregnancy Childbirth. 2015;15:143. doi:10.1186/s12884-015-0579-z.
Gold KJ, Leon I, Boggs ME, Sen A. Depression and posttraumatic stress symptoms after perinatal loss in a population-based sample. J Women's Health. 2015. doi:10.1089/jwh.2015.5284. Largest epidemiologically based study of psychological reactions to perinatal loss. Using surveys, the authors found high rates of distress and low treatment rates 9 months after loss.
Cheung C, Chan C, Ng E. Stress and anxiety‐depression levels following first‐trimester miscarriage: a comparison between women who conceived naturally and women who conceived with assisted reproduction. BJOG. 2013;120(9):1090–7.
Neugebauer R, Kline J, Shrout P, Skodol A, O'Connor P, Geller PA, et al. Major depressive disorder in the 6 months after miscarriage. JAMA. 1997;277(5):383–8.
Lok IH, Yip AS, Lee DT, Sahota D, Chung TK. A 1-year longitudinal study of psychological morbidity after miscarriage. Fertil Steril. 2010;93(6):1966–75. doi:10.1016/j.fertnstert.2008.12.048.
Munk-Olsen T, Bech BH, Vestergaard M, Li J, Olsen J, Laursen TM. Psychiatric disorders following fetal death: a population-based cohort study. BMJ Open. 2014;4(6):e005187. doi:doi:10.1136/bmjopen-2014-005187.
Gravensteen IK, Helgadottir LB, Jacobsen EM, Sandset PM, Ekeberg O. Long-term impact of intrauterine fetal death on quality of life and depression: a case-control study. BMC Pregnancy Childbirth. 2012;12:43. doi:10.1186/1471-2393-12-43.
Geller PA, Kerns D, Klier CM. Anxiety following miscarriage and the subsequent pregnancy: a review of the literature and future directions. J Psychosom Res. 2004;56(1):35–45. doi:10.1016/s0022-3999(03)00042-4.
Broen AN, Moum T, Bodtker AS, Ekeberg O. The course of mental health after miscarriage and induced abortion: a longitudinal, five-year follow-up study. BMC Med. 2005;3:18. doi:10.1186/1741-7015-3-18.
Gold KJ, Boggs ME, Muzik M, Sen A. Anxiety disorders and obsessive compulsive disorder 9 months after perinatal loss. Gen Hosp Psychiatry. 2014;36(6):650–4.
Daugirdaite V, van den Akker O, Purewal S. Posttraumatic stress and posttraumatic stress disorder after termination of pregnancy and reproductive loss: a systematic review. J Pregnancy. 2015;2015:646345. doi:10.1155/2015/646345. A systematic review including 48 studies summarizes risk factors for developing posttraumatic stress and post traumatic stress disorder after reproductive loss.
Gissler M, Hemminki E, Lonnqvist J. Suicides after pregnancy in Finland, 1987–94: register linkage study. BMJ. 1996;313(7070):1431–4.
Qin P, Mortensen PB. The impact of parental status on the risk of completed suicide. Arch Gen Psychiatry. 2003;60(8):797–802. doi:10.1001/archpsyc.60.8.797.
Hvidtjorn D, Wu C, Schendel D, Thorlund Parner E, Brink Henriksen T. Mortality in mothers after perinatal loss: a population-based follow-up study. BJOG. 2015. doi:10.1111/1471-0528.13268.
Nynas J, Narang P, Kolikonda MK, Lippmann S Depression and anxiety following early pregnancy loss: recommendations for primary care providers. The Primary Care Companion for CNS Disorders 2015; 17(1) doi:10.4088/PCC.14r01721.
Chojenta C, Harris S, Reilly N, Forder P, Austin M-P, Loxton D. History of pregnancy loss increases the risk of mental health problems in subsequent pregnancies but not in the postpartum. PLoS One. 2014;9(4):e95038. doi:10.1371/journal.pone.0095038.
Kinsey CB, Baptiste-Roberts K, Zhu J, Kjerulff KH. Effect of previous miscarriage on depressive symptoms during subsequent pregnancy and postpartum in the first baby study. Matern Child Health J. 2015;19(2):391–400.
Blackmore ER, Côté-Arsenault D, Tang W, Glover V, Evans J, Golding J, et al. Previous prenatal loss as a predictor of perinatal depression and anxiety. Br J Psychiatry. 2011;198(5):373–8. doi:10.1192/bjp.bp.110.083105.
Giannandrea SAM, Cerulli C, Anson E, Chaudron LH. Increased risk for postpartum psychiatric disorders among women with past pregnancy loss. J Women's Health. 2013;22(9):760–8. doi:10.1089/jwh.2012.4011.
Bergner A, Beyer R, Klapp BF, Rauchfuss M. Pregnancy after early pregnancy loss: a prospective study of anxiety, depressive symptomatology and coping. J Psychosom Obstet Gynaecol. 2008;29(2):105–13. doi:10.1080/01674820701687521.
Woods-Giscombe CL, Lobel M, Crandell JL. The impact of miscarriage and parity on patterns of maternal distress in pregnancy. Res Nurs Health. 2010;33(4):316–28. doi:10.1002/nur.20389.
McCarthy FP, Moss-Morris R, Khashan AS, North RA, Baker PN, Dekker G, et al. Previous pregnancy loss has an adverse impact on distress and behaviour in subsequent pregnancy. BJOG. 2015. doi:10.1111/1471-0528.13233.
Klier CM, Geller PA, Ritsher JB. Affective disorders in the aftermath of miscarriage: a comprehensive review. Arch Women Mental Health. 2002;5(4):129.
Lewis J, Azar R. Depressive symptoms in men post-miscarriage. J Men Health. 2015;11(5):8–13.
O'Leary JM, Gaziano C. Sibling grief after perinatal loss. J Prenat Perinat Psychol Health. 2011;25(3):173.
Lok IH, Lee DT, Yip SK, Shek D, Tam WH, Chung TK. Screening for post-miscarriage psychiatric morbidity. Am J Obstet Gynecol. 2004;191(2):546–50. doi:10.1016/j.ajog.2004.01.003.
Swanson KM, Connor S, Jolley SN, Pettinato M, Wang TJ. Contexts and evolution of women’s responses to miscarriage during the first year after loss. Res Nurs Health. 2007;30(1):2–16. doi:10.1002/nur.20175.
Toedter LJ, Lasker JN, Alhadeff JM. The perinatal grief scale: development and initial validation. Am J Orthopsychiatry. 1988;58(3):435.
Beutel M, Will H, Voelkl K, von Rad M, Weiner H. Assessment of grief exemplified pregnancy loss: development and initial results on the validity of the Munich grief scale. Psychother Psychosom Med Psychol. 1994;45(9–10):295–302.
Ritsher JB, Neugebauer R. Perinatal bereavement grief scale: distinguishing grief from depression following miscarriage. Assessment. 2002;9(1):31–40.
Hutti MH, de Pacheco M, Smith M. A study of miscarriage: development and validation of the perinatal grief intensity scale. J Obstet Gynecol Neonatal Nurs. 1998;27(5):547–55.
Murphy FA, Lipp A, Powles DL. Follow-up for improving psychological well being for women after a miscarriage. Cochrane Database Syst Rev. 2012;3:CD008679. doi:10.1002/14651858.CD008679.pub2.
Swanson KM, Chen H-T, Graham JC, Wojnar DM, Petras A. Resolution of depression and grief during the first year after miscarriage: a randomized controlled clinical trial of couples-focused interventions. J Women's Health. 2009;18(8):1245–57.
Koopmans L, Wilson T, Cacciatore J, Flenady V. Support for mothers, fathers and families after perinatal death. Cochrane Database Syst Rev. 2013;6:CD000452. doi:10.1002/14651858.CD000452.pub3.
Hughes P, Turton P, Hopper E, Evans C. Assessment of guidelines for good practice in psychosocial care of mothers after stillbirth: a cohort study. Lancet. 2002;360(9327):114–8.
Turton P, Evans C, Hughes P. Long-term psychosocial sequelae of stillbirth: phase II of a nested case-control cohort study. Arch Women Mental Health. 2009;12(1):35–41. doi:10.1007/s00737-008-0040-7.
Gold KJ, Dalton VK, Schwenk TL. Hospital care for parents after perinatal death. Obstet Gynecol. 2007;109(5):1156–66. doi:10.1097/01.AOG.0000259317.55726.df.
Kingdon C, Givens JL, O'Donnell E, Turner M. Seeing and holding baby: systematic review of clinical management and parental outcomes after stillbirth. Birth. 2015;42(3):206–18. doi:10.1111/birt.12176. Systematic review that provides evidence based recommendations for parents holding their stillborn child.
Peters MD, Lisy K, Riitano D, Jordan Z, Aromataris E. Caring for families experiencing stillbirth: evidence-based guidance for maternity care providers. Women Birth. 2015. doi:10.1016/j.wombi.2015.07.003.
Robinson GE. Pregnancy loss. Baillières Best Pract Res Clin Obstet Gynaecol. 2014;28(1):169–78. doi:10.1016/j.bpobgyn.2013.08.012.
Rosenbaum JL, Smith JR, Yan Y, Abram N, Jeffe DB. Impact of a neonatal-bereavement-support DVD on parental grief: a randomized controlled trial. Death Stud. 2015;39(4):191–200.
Kersting A, Dölemeyer R, Steinig J, Walter F, Kroker K, Baust K, et al. Brief Internet-based intervention reduces posttraumatic stress and prolonged grief in parents after the loss of a child during pregnancy: a randomized controlled trial. Psychother Psychosom. 2013;82(6):372–81. doi:10.1159/000348713.
Roberts LR, Montgomery SB. Mindfulness-based intervention for perinatal grief after stillbirth in rural India. Issue Mental Health Nurs. 2015;36(3):222–30.
Huberty J, Leiferman JA, Gold KJ, Rowedder L, Cacciatore J, McClain DB. Physical activity and depressive symptoms after stillbirth: informing future interventions. BMC Pregnancy Childbirth. 2014;14:391. doi:10.1186/s12884-014-0391-1.
Chaudron LH. Complex challenges in treating depression during pregnancy. Am J Psychiatry. 2013;170(1):12–20. doi:10.1176/appi.ajp.2012.12040440. Clinical recommendations based on summaries of effects of untreated depression and antidepressants during pregnancy.
Stephansson O, Kieler H, Haglund B, et al. Selective serotonin reuptake inhibitors during pregnancy and risk of stillbirth and infant mortality. JAMA. 2013;309(1):48–54. doi:10.1001/jama.2012.153812.
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Amritha Bhat is a postdoctoral fellow in the NIMH T32 MH20021 Psychiatry-Primary Care Fellowship Program Training Grant PI Unutzer 07/01/15–06/30/17.
Nancy Byatt has received grant funding/support for this project from the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grants KL2TR000160 and KL2TR001455. Dr. Byatt has also received salary and funding support from the Massachusetts Department of Mental Health via the Massachusetts Child Psychiatry Access Project for Moms (MCPAP for Moms) and is the Medical Director of MCPAP for Moms.
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Bhat, A., Byatt, N. Infertility and Perinatal Loss: When the Bough Breaks. Curr Psychiatry Rep 18, 31 (2016). https://doi.org/10.1007/s11920-016-0663-8
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DOI: https://doi.org/10.1007/s11920-016-0663-8