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A Review of the Use of Stellate Ganglion Block in the Treatment of PTSD

  • Military Mental Health (CH Warner, Section Editor)
  • Published:
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Abstract

Current treatments for PTSD are often not effective or acceptable to the patient. There are a number of emerging new treatments. One promising new one is stellate ganglion block, an anesthetic treatment for pain which relieves symptoms of severe and chronic PTSD in some patients. The focus of this chapter is to summarize clinical evidence available for the effectiveness of cervical sympathetic ganglion injection called stellate ganglion block (SGB), as well as demonstrate possible clinical applications of its use. Cervical sympathetic blockade involves injecting a local anesthetic next to a group of nerves (ganglion) in the neck. The technique has been used clinically since 1925 with very few side effects. Finally, the neurobiology of SGB is discussed. Challenges to the use of SGB include the lack of randomized clinical trials and practitioners familiar with the use of SGB for PTSD.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Da Costa JM. On irritable heart; a clinical study of a form of functional cardiac disorder and its consequences. Am J Med Sci. 1871;121(1):2–52.

    Article  Google Scholar 

  2. Gore AT, Richards-Reid GM. Posttraumatic stress disorder. Updated December 18, 2006. eMedicine [serial online]. Available at: http://www.emedicine.com/med/topic1900.htm. Accessed 21 Oct 2007.

  3. Institute of Medicine. Treatment of posttraumatic stress disorder: an assessment of the evidence. Washington, DC: The National Academies Press; 2007.

    Google Scholar 

  4. Hoge CW. Interventions for war-related posttraumatic stress disorder: meeting veterans where they are. JAMA. 2011;306:549–51. Dr Hoge is a military psychiatrist who is highly respected in the community and is able to give an over view of the treatment difficulty involved on military PTSD.

    Article  CAS  PubMed  Google Scholar 

  5. Southwick SM, Bremner JD, Rasmusson A, et al. Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biol Psychiatry. 1999;46:1192–204.

    Article  CAS  PubMed  Google Scholar 

  6. Mason JW, Giller EL, Kosten TR, et al. Elevation of urinary norepinephrine/cortisol ratio in posttraumatic stress disorder. J Nerv Ment Dis. 1988;176:498–502.

    Article  CAS  PubMed  Google Scholar 

  7. Geracioti TD, Baker DG, Ekhator NN, et al. CSF norepinephrine concentrations in posttraumatic stress disorder. Am J Psychiatry. 2001;158:1227–30.

    Article  PubMed  Google Scholar 

  8. Taylor FB, Lowe K, Thompson C, et al. Daytime prazosin reduces psychological distress to trauma specific civilian trauma post traumatic stress disorder. Biol Psychiatry. 2006;59:577–81.

    Article  CAS  PubMed  Google Scholar 

  9. Lipov EG, Joshi JR, Lipov SG, Sanders SE, Siroko MK. Cervical sympathetic blockade in a patient with posttraumatic stress disorder: a case report. Ann Clin Psychiatry. 2008;20:227–8.

    Article  PubMed  Google Scholar 

  10. Alino J, Kosatka D, McLean B, et al. Efficacy of stellate ganglion block in the treatment of anxiety symptoms from combat-related post- traumatic stress disorder: a case series. Mil Med. 2013;178:473–7. This is a paper on a small number of patients, n = 4, however this is the first report of SGB effecting suicidal ideation.

    Article  Google Scholar 

  11. Mulvaney SW, McLean B, De Leeuw J. The use of stellate ganglion block in the treatment of panic/anxiety symptoms with combat-related post-traumatic stress disorder; preliminary results of long-term follow-up: a case series. Pain Pract. 2010;10:349–65.

    Article  Google Scholar 

  12. Mulvaney SW, Lynch JH, Hickey MJ, et al. Stellate ganglion block used to treat symptoms associated with combat-related post-traumatic stress disorder: a case series of 166 patients. Mil Med. 2014;179(10):1133–40. This is the largest publication so far on the use of SGB in military PTSD.

    Article  PubMed  Google Scholar 

  13. Alkire M T, Hollifield M, Khoshsar R, et al. Prolonged relief of chronic extreme PTSD and depression symptoms in veterans following a stellate ganglion block. Presented at American Society of Anesthesiology, October 11, 2014. This publication summarizes the results of a first prospective study in VA, as well as the most severe PTSD patients in the same VA.

  14. Lipov EG, Joshi JR, et al. A unifying theory linking the prolonged efficacy of the stellate ganglion block for the treatment of chronic regional pain syndrome (CRPS), hot flashes, and posttraumatic stress disorder (PTSD). Med Hypotheses. 2009;72(6):657–61.

    Article  PubMed  Google Scholar 

  15. Hickey AH, Hanling S, Pevney E, et al. Stellate ganglion block for PTSD. Am J Psychiatry. 2012;169:760.

    Article  Google Scholar 

  16. Westerhaus MJ, Loewy AD. Central representation of the sympathetic nervous system in the cerebral cortex. Brain Res. 2001;903:117–27.

    Article  CAS  PubMed  Google Scholar 

  17. Liberzon I, Martis B. Neuroimaging studies of emotional responses in PTSD. Ann N Y Acad Sci. 2006;1071:87–109.

    Article  PubMed  Google Scholar 

  18. Alleva E, Petruzzi S, Cirulli F, et al. NGF regulatory role in stress and coping of rodents and humans. Pharmacol Biochem Behav. 1996;54:65–72.

    Article  CAS  PubMed  Google Scholar 

  19. Smith MA. Hippocampal vulnerability to stress and aging: possible role of neurotrophic factors. Behav Brain Res. 1996;78:25–36.

    Article  CAS  PubMed  Google Scholar 

  20. Isaacson LG, Billieu SC. Increased perivascular norepinephrine following intracerebroventricular infusion of NGF into adult rats. Exp Neurol. 1996;139(1):54–60.

    Article  CAS  PubMed  Google Scholar 

  21. Morilak DA, Barrera G, Echevarria DJ, et al. Role of brain norepinephrine in the behavioral response to stress. Prog Neuro-Psychopharmacol Biol Psychiatry. 2005;29(8):1214–24.

    Article  CAS  Google Scholar 

  22. Johnson Jr EM, Taniuchi M, Clark HB, et al. Demonstration of the retrograde transport of nerve growth factor receptor in the peripheral and central nervous system. J Neurosci. 1987;7:923–5.

    CAS  PubMed  Google Scholar 

  23. Chen PS, Chen LS, Cao JM, Sharifi B, Karagueuzian HS, Fishbein MC. Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death. Cardiovasc Res. 2001;50(2):409–16.

    Article  CAS  PubMed  Google Scholar 

  24. Madison R, Davis JN. Sprouting of noradrenergic fibers in hippocampus after medial septal lesions: contributions of the central and peripheral nervous systems. Exp Neurol. 1983;80(1):167–77.

    Article  CAS  PubMed  Google Scholar 

  25. Takatori T, Kuroda Y, Hirose M. Local anesthetics suppress nerve growth factor-mediated neurite outgrowth by inhibition of tyrosine kinase activity of TrkA. Anesth Analg. 2006;102:462–7.

    Article  CAS  PubMed  Google Scholar 

  26. Gatzinsky KP, Thrasivoulou C, Campioni-Noack M, Underwood C, Cowen T. The role of NGF uptake in selective vulnerability to cell death in ageing sympathetic neurons. Eur J Neurosci. 2004;20(11):2848–56.

    Article  PubMed  Google Scholar 

  27. Jeong S, Jeon Y, Yeo J, Baek W. The effects of stellate ganglion block on the electroencephalogram in rats. J Anesth. 2014;28(4):601–5. These results indicate that SGB may have a sedative effect in rats.

  28. Yeo J, Jeon Y. Effects of stellate ganglion block on sedation as assessed by bispectral index in normal healthy volunteers. Pain Physician. 2015;18:173–8.

    PubMed  Google Scholar 

  29. Wulf H, Maier CH. Complications of stellate ganglion blockade: results of a survey. Anaesthetist. 1992;41:146–51.

    CAS  Google Scholar 

  30. Navaie M, Keefe MS, Hickey AH, et al. Use of stellate ganglion block for refractory post-traumatic stress disorder: a review of published cases. J Anesth Clin Res. 2014;5(403):2. This is a critical paper summarizing evidence so far as reported up until August 2014.

    Google Scholar 

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Eugene Lipov and Elspeth Cameron Ritchie declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Correspondence to Elspeth Cameron Ritchie.

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This article is part of the Topical Collection on Military Mental Health

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Lipov, E., Ritchie, E.C. A Review of the Use of Stellate Ganglion Block in the Treatment of PTSD. Curr Psychiatry Rep 17, 63 (2015). https://doi.org/10.1007/s11920-015-0599-4

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