Proceed with Caution: Off-label Ketamine Treatment for Major Depressive Disorder
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Ketamine offers a promising new option for the treatment of depression, but its increasing off-label use is ethically and clinically inappropriate at the moment.
KeywordsKetamine Depression Ethics Consent Safety
Compliance with Ethics Guidelines
Conflict of Interest
Dominic Sisti and Andrea G. Segal declare that they have no conflict of interest.
Michael Thase reports personal fees from Alkermes, AstraZeneca, Bristol-Myers Squibb Company, Gerson Lehman Group, GlaxoSmithKline, Guidepoint Global, H. Lundbeck A/S, MedAvante, Merck and Co., Neuronetics, Inc., Ortho-McNeil Pharmaceuticals, Pfizer, Roche, Shire US, Inc., Sunovion Pharmaceuticals, Inc., and Takeda. Dr. Thase also has received grants and personal fees from Eli Lilly & Co., Forest Laboratories, and Otsuka as well as royalties from the American Psychiatric Foundation, Guilford Publications, Herald House, W.W. Norton & Company, Inc., and Peloton Advantage.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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