Sleep and Substance Use Disorders: An Update

Abstract

Substance use disorders (SUD) are common and individuals who suffer from them are prone to relapse. One of the most common consequences of the use of and withdrawal from substances of abuse is sleep disturbance. Substances of abuse affect sleep physiology, including the neurotransmitter systems that regulate the sleep-wake system. Emerging research now highlights an interactive effect between sleep disorders and substance use. New findings in alcohol and sleep research have utilized sophisticated research designs and expanded the scope of EEG and circadian rhythm analyses. Research on marijuana and sleep has progressed with findings on the effects of marijuana withdrawal on objective and subjective measures of sleep. Treatment studies have focused primarily on sleep in alcohol use disorders. Therapies for insomnia in cannabis disorders are needed. Future research is poised to further address mechanisms of sleep disturbance in alcoholics and the effect of medical marijuana on sleep and daytime functioning.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. 1.

    Mokdad AH, Marks JS, Stroup DF, Gerberding JL. Actual Causes of Death in the United States, 2000. JAMA. 2004;291(10):1238–45. doi:10.1001/jama.291.10.1238.

    Article  PubMed  Google Scholar 

  2. 2.

    NIDA. Understanding Drug Abuse and Addiction. 2012.

  3. 3.

    Cohn T, Foster J, Peters T. Sequential studies of sleep disturbance and quality of life in abstaining alcoholics. Addict Biol. 2003;8:455–62.

    Article  CAS  PubMed  Google Scholar 

  4. 4.

    Brower K. Alcohol's effects on sleep in alcoholics. Alcohol Res Health. 2001;25:110–25.

    CAS  PubMed Central  PubMed  Google Scholar 

  5. 5.

    Roehrs T, Roth T. Sleep, sleepiness, sleep disorders and alcohol use and abuse. Sleep Med Rev. 2001;5(4):287–97.

    Article  PubMed  Google Scholar 

  6. 6.

    Bolla K, Lesage S, Gamaldo C, Neubauer D, Funderburk F, Cadet J, et al. Sleep disturbance in heavy marijuana users. Sleep. 2008;31(6):901–8.

    PubMed Central  PubMed  Google Scholar 

  7. 7.

    Colrain I, Trinder J, Swan G. The impact of smoking cessation on objective and subjective markers of sleep: review, synthesis, and recommendations. Nicotine Tob Res. 2004;6:913–25.

    Article  PubMed  Google Scholar 

  8. 8.

    Roehrs T, Roth T. Caffeine: Sleep and daytime sleepiness. Sleep Med Rev. 2008;12(2):153–62.

    Article  PubMed  Google Scholar 

  9. 9.

    Schierenbeck T, Riemann D, Berger M, Hornyak M. Effect of illicit recreational recreational drug use upon sleep: Cocaine, ecstasy, and marijuana. Sleep Med Rev. 2008;12:381–9.

    Article  PubMed  Google Scholar 

  10. 10.

    Papineau K, Roehrs T, Petrucelli N, Rosenthal L, Roth T. Electrophysiological assessment (The Multiple Sleep Latency Test) of the biphasic effects of ethanol in humans. Alcohol Clin Exp Res. 1998;22(1):231–5.

    CAS  PubMed  Google Scholar 

  11. 11.

    Aldrich M, Shipley J. Alcohol use and periodic limb movements of sleep. Alcohol Clin Exp Res. 1993;17(1):192–6.

    Article  CAS  PubMed  Google Scholar 

  12. 12.

    Aldrich MS, Brower KJ, Hall JM. Sleep-disordered breathing in alcoholics. Alcohol Clin Exp Res. 1999;23:134–40.

    Article  CAS  PubMed  Google Scholar 

  13. 13.

    Rosenthal L, Roehrs T, Zwyghuizen-Doorenbos A, Plath D, Roth T. Alerting effects of caffeine after normal and restricted sleep. Neuropsychopharmacology. 1991;42(2):103–8.

    Google Scholar 

  14. 14.

    Prosise G, Bonnet M, Berry R, Dickel M. Effects of abstinence from smoking on sleep and daytime sleepiness. Chest. 1994;105(4):1136–41.

    Article  CAS  PubMed  Google Scholar 

  15. 15.

    Roehrs T, Papineau K, Rosenthal L, Roth T. Sleepiness and the reinforcing and subjective effects of methylphenidate. Exp Clin Psychopharmacol. 1999;7(2):145–50.

    Article  CAS  PubMed  Google Scholar 

  16. 16.

    Johanson C, Roehrs T, Schuh K, Warbasse L. The effects of cocaine on mood and sleep in cocaine-dependent males. Exp Clin Psychopharmacol. 1999;7(4):338–46.

    Article  CAS  PubMed  Google Scholar 

  17. 17.

    Walker J, Farney R, Rhondeau S, Boyle K, Valentine K, Cloward T, et al. Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing. J Clin Sleep Med. 2007;3(5):455–61.

    PubMed Central  PubMed  Google Scholar 

  18. 18.

    Comasco E, Nordquist N, Gokturk C, Aslund C, Hallman J, Oreland L, et al. The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents. Ups J Med Sci. 2010;115:41–8.

    Article  PubMed Central  PubMed  Google Scholar 

  19. 19.

    Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Magnone M, et al. The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nat Med. 2005;11(1):35–42.

    Article  CAS  PubMed  Google Scholar 

  20. 20.

    Spanagel R, Rosenwasser A, Schumann G, Sarkar D. Alcohol consumption and the body's biological clock. Alcohol Clin Exp Res. 2005;29(8):1550–7.

    Article  PubMed  Google Scholar 

  21. 21.

    Wang X, Mozhui K, Li Z, Mulligan M, Ingels J, Zhou X et al. A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. Transl Psychiatry 2012;2(e73).

  22. 22.•

    Clasadonte J, McIver S, Schmitt L, Halassa M, Haydon P. Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine. J Neurosci. 2014;34(5):1879–91. This study showed that chronic alcohol intake appears to induce alterations in homeostatic sleep drive in animals.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. 23.

    Baimel C, Bartlett S, Chiou L, Lawrence A, Muschamp J, Patkar O, et al. Orexin/hypocretin role in reward: implications for opioid and other addictions. Br J Pharmacol. 2014. doi:10.1111/bph.12639.

    PubMed  Google Scholar 

  24. 24.

    Cahill E, Salery M, Vanhoutte P, Caboche J. Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse. Front Pharmacol. 2014;4:172. doi:10.3389/fphar.2013.00172.

    Article  PubMed Central  PubMed  Google Scholar 

  25. 25.

    Koob G. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Curr Top Behav Neurosci. 2013;13:3–30.

    Article  PubMed Central  PubMed  Google Scholar 

  26. 26.

    Matzeu A, Zamora-Martinez E, Martin-Fardon R. The paraventricular nucleus of the thalamus is recruited by both natural rewards and drugs of abuse: recent evidence of a pivotal role for orexin/hypocretin signaling in this thalamic nucleus in drug-seeking behavior. Front Behav Neurosci. 2014;8:117. doi:10.3389/fnbeh.2014.00117. eCollection 2014.

    Article  PubMed Central  PubMed  Google Scholar 

  27. 27.

    Hyman S, Malenka R, Nestler E. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci. 2006;29:565–98.

    Article  CAS  PubMed  Google Scholar 

  28. 28.

    Brown R, Basheer R, McKenna J, Strecker R, McCarley R. Control of sleep and wakefulness. Physiol Rev. 2012;92(3):1087–187.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. 29.

    Hasler B, Sitnick S, Shaw D, Forbes E. An altered neural response to reward may contribute to alcohol problems among late adolescents with an evening chronotype. Psychiatry Res. 2013;214(3):357–64.

    Article  PubMed  Google Scholar 

  30. 30.

    Johnson EO, Breslau N. Sleep problems and substance use in adolescence. Drug Alcohol Depend. 2001;64(1):1–7.

    Article  CAS  PubMed  Google Scholar 

  31. 31.

    Roane BM, Taylor DJ. Adolescent insomnia as a risk factor for early adult depression and substance abuse. Sleep. 2008;31(10):1351–6.

    PubMed Central  PubMed  Google Scholar 

  32. 32.

    Kenney S, Paves A, Grimaldi E, Labrie J. Sleep Quality and Alcohol Risk in College Students: Examining the Moderating Effects of Drinking Motives. J Am Coll Health. 2014.

  33. 33.

    Popovici I, French M. Binge drinking and sleep problems among young adults. Drug Alcohol Depend. 2013;132(1–2):207–15.

    Article  PubMed Central  PubMed  Google Scholar 

  34. 34.

    Taylor D, Bramoweth A. Patterns and consequences of inadequate sleep in college students: Substance use and motor vehicle accidents. J Adolescents Health. 2010;46:610–2.

    Article  Google Scholar 

  35. 35.

    Zhabenko O, Krentzman A, Robinson E, Brower K. A longitudinal study of drinking and depression as predictors of insomnia ini alcohol-dependent individuals. Subst Use Misuse. 2013;48(7):495–505.

    Article  PubMed  Google Scholar 

  36. 36.

    Wong M, Brower KJ, Fitzgerald H, Zucker R. Sleep problems in early childhood and early onset of alcohol and other drug use in adolescence. Alcohol: Clin Exp Res. 2004;28(4):578–87.

    Article  Google Scholar 

  37. 37.

    Wong M, Brower K. The prospective relationship between sleep problems and suicidal behavior in the National Longitudinal Study of Adolescent Health. J Psychiatr Res. 2012;46(7):953–9.

    Article  PubMed Central  PubMed  Google Scholar 

  38. 38.

    Wong M, Brower K, Nigg J, Zucker R. Childhood sleep problems, response inhibition, and alcohol and drug outcomes in adolescence and young adulthood. Alcohol Clin Exp Res. 2010;34(6):1–12.

    Google Scholar 

  39. 39.

    Pasch K, Latimer L, Duncan J, Moe S, Lytle L. Longitudinal Bi-directional relationship between sleep and substance use. J Youth Adolesc. 2012;41:1184–96.

    Article  PubMed Central  PubMed  Google Scholar 

  40. 40.

    Hasler B, Martin C, Wood D, Rosario B, Clark D. A Longitudinal Study of Insomnia and Other Sleep Complaints in Adolescents With and Without Alcohol Use Disorders. Alcohol Clin Exp Res. 2014. doi:10.1111/acer.12474.

    PubMed  Google Scholar 

  41. 41.

    Dahl R. The impact of inadequate sleep on children’s daytime cognitive function. Semin Pediatr Neurol. 1996;3(1):44–50.

    Article  CAS  PubMed  Google Scholar 

  42. 42.

    Dahl R, Lewin D. Pathways to adolescent health: Sleep regulation and behavior. J Adolesc Health. 2002;31:175–84.

    Article  PubMed  Google Scholar 

  43. 43.

    Wills T, Cleary S, Filer M, Shinar O, Mariani J, Spera K. Temperament related to early-onset substance use: test of a developmental model. Prev Sci. 2001;2(3):145–63.

    Article  CAS  PubMed  Google Scholar 

  44. 44.

    Hasler B, Dahl R, Holm S, Jakubcak J, Ryan N, Silk J, et al. Weekend-weekday advances in sleep timing are associated with altered reward-related brain function in healthy adolescents. Biol Psychol. 2012;91(3):334–41.

    Article  PubMed Central  PubMed  Google Scholar 

  45. 45.

    Diagnostic and Statistical Manual of Mental Disorders (Fifth ed.). Arlington, VA: American Psychiatric Publishing. 2013.

  46. 46.

    American Academy of Sleep Medicine. International Classification of Sleep Disorders 3rd Edition. Darien. 2014.

  47. 47.

    Grant B, Stinson F, Dawson D, Chou S, Dufour M, Compton W, et al. Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry. 2004;61:807–16.

    Article  PubMed  Google Scholar 

  48. 48.

    Huebner R, Kantor L. Advances in Alcoholism Treatment. Alcohol Res Health. 2011;33(4):295–9.

    PubMed Central  PubMed  Google Scholar 

  49. 49.

    Arnedt J, Rohsenow D, Almeida A, Hunt S, Gokhale M, Gottlieb D, et al. Sleep following alcohol intoxication in healthy, young adults: effects of sex and family history of alcoholism. Alcohol Clin Exp Res. 2011;35(5):870–8.

    Article  PubMed Central  PubMed  Google Scholar 

  50. 50.

    Pressman M. Alcohol does not increase slow wave sleep. Alcohol Clin Exp Res. 2012;36(8):1474.

    Article  PubMed  Google Scholar 

  51. 51.

    Pressman M, Mahowald M, Schenck C. Alcohol, sleepwalking and violence: lack of reliable scientific evidence. Brain. 2013;136(Pt 2):e229.

    Article  PubMed  Google Scholar 

  52. 52.

    Wittmann M, Paulus M, Roenneberg T. Decreased psychological well-being in late 'chronotypes' is mediated by smoking and alcohol consumption. Subst Use Misuse. 2010;45(1–2):15–30.

    Article  PubMed  Google Scholar 

  53. 53.

    Rupp T, Acebo C, Carskadon M. Evening alcohol suppresses salivary melatonin in young adults. Chronobiol Int. 2007;24(3):463–70.

    Article  CAS  PubMed  Google Scholar 

  54. 54.

    Hasler B, Bootzin R, Cousins J, Fridel K, Wenk G. Circadian phase in sleep-disturbed adolescents with a history of substance abuse: A pilot study. Behav Sleep Med. 2008;6:55–73.

    Article  PubMed  Google Scholar 

  55. 55.

    Kuhlwein E, Hauger R, Irwin M. Abnormal nocturnal melatonin secretion and disordered sleep in abstinent alcoholics. Biol Psychiatry. 2003;54(12):1437–43.

    Article  CAS  PubMed  Google Scholar 

  56. 56.

    Conroy DA, Hairston IS, Arnedt JT, Hoffmann RF, Armitage R, Brower KJ. Dim light melatonin onset in alcohol-dependent men and women compared with healthy controls. Chronobiol Int. 2012;29(1):35–42. doi:10.3109/07420528.2011.636852.

    Article  CAS  PubMed  Google Scholar 

  57. 57.

    Burgess H, Gorenz A, Keshavarzian A, Swanson G. Sleep and melatonin in actively drinking alcoholics. Sleep. 2014;37(Abstract supplement).

  58. 58.

    Johnston L, O’Malley P, Bachman J, Schulenberg J. Monitoring the Future national survey results on drug use, 1975-2006: Volume II, College students and adults ages 19-45. Bethesda: National Institute on Drug Abuse; 2007.

    Google Scholar 

  59. 59.

    Johnston L, O’Malley P, Bachman J, Schulenberg J. Monitoring the Future national survey results on drug use, 1975-2007: Volume I, Secondary school students. Bethesda: National Institute on Drug Abuse; 2008.

    Google Scholar 

  60. 60.

    Johnston L, O'Malley P, Bachman J, Schulenberg J. Monitoring the Future national survey results on drug use, 1975-2012: College students and adults ages 19-50. Ann Arbor: Institute for Social Research The University of Michigan; 2013.

    Google Scholar 

  61. 61.

    Johnston L, O'Malley P, Bachman J, Shulenberg L. Monitoring the Future national survey results on drug use, 1975-2003. National Institute on Drug Abuse. 2004;1: Secondary School Students.

  62. 62.

    Bonn-Miller M, Babson K, Vandrey R. Using cannabis to help you sleep: heightened frequency of medical cannabis use among those with PTSD. Drug Alcohol Depend. 2014;136:162–5.

    Article  PubMed  Google Scholar 

  63. 63.

    Bonn-Miller M, Babson K, Vujanovic A. Sleep problems and PTSD symptoms interact to predict marijuana use coping motives. J Dual Diagn. 2010;6:111–2.

    Article  Google Scholar 

  64. 64.

    Walsh Z, Callaway R, Belle-Isle L, Caplere R, Kayf R, Lucasd P, et al. Cannabis for therapeutic purposes: Patient characteristics, access, and reasons for use. Int J Drug Policy. 2013;24:511–6.

    Article  PubMed  Google Scholar 

  65. 65.

    Cousins K, DiMascio A. THC as an Hypnotic: An Experimental Study of Three Dose Levels. Psychopharmacologia. 1973;33:355–64.

    Article  Google Scholar 

  66. 66.

    Nicholson AN, Turner C, Stone BM, Robson PJ. Effects of ∆–9-Tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. J Clin Psychopharmacol. 2004;24(3):305–13.

    Article  CAS  PubMed  Google Scholar 

  67. 67.

    Feinberg I, Jones R, Walker JM, Cavness C, March J. Effects of high dosage delta-9-tetrahydrocannabinol on sleep patterns in man. Clin Pharmacol Ther. 1975;17(4):458–66.

    CAS  PubMed  Google Scholar 

  68. 68.

    Gillin JC, Kotin J, Post R, et al. Sleep during one week of administration of ∆-9-tetrahydrocannabinol to psychiatric patients. Sleep Res. 1972;1:44.

    Google Scholar 

  69. 69.

    Barratt ES, Beaver W, White R. The effects of marijuana on human sleep patterns. Biol Psychiatry. 1974;8(1):47–54.

    CAS  PubMed  Google Scholar 

  70. 70.

    Conroy D, Arnedt J, Brower K, Strobbe S, Consens F, Hoffmann R, et al. Perception of sleep in recovering alcohol dependent patients with insomnia: relationship with future drinking. Alcohol Clin Exp Res. 2006;30(12):1986–99.

    Article  Google Scholar 

  71. 71.

    Colrain I, Turlington S, Baker F. Impact of alcoholism on sleep architecture and EEG power spectra in men and women. Sleep. 2009;32(19):1341–52.

    PubMed Central  PubMed  Google Scholar 

  72. 72.

    Drummond S, Gillin J, Smith T, DeModena A. The sleep of abstinent pure primary alcoholic patients: natural course and relationship to relapse. Alcohol Clin Exp Res. 1998;22:1796–802.

    CAS  PubMed  Google Scholar 

  73. 73.

    Brower K, Hoffmann R, Conroy D, Arnedt J, Armitage R. Sleep homeostasis in alcohol-dependent, depressed and healthy control men. Eur Arch Psychiatry Clin Neurosci. 2011;261(8):559–66. doi:10.1007/s00406-011-0195-5.

    Article  PubMed Central  PubMed  Google Scholar 

  74. 74.

    Armitage R, Hoffmann R, Conroy DA, Arnedt JT, Brower KJ. Effects of a 3-hour sleep delay on sleep homeostasis in alcohol dependent adults. Sleep. 2012;35(2):273–8. doi:10.5665/sleep.1638.

    PubMed Central  PubMed  Google Scholar 

  75. 75.

    de Zambotti M, Baker F, Sugarbaker D, Nicholas C, Trinder J, Colrain I. Poor Autonomic Nervous System Functioning During Sleep in Recently Detoxified Alcohol-Dependent Men and Women. Alcohol Clin Exp Res. 2014.

  76. 76.

    Amzica F, Steriade M. The K-complex: its slow (<1-Hz) rhythmicity and relation to delta waves. Neurology. 1997;49:952–9.

    Article  CAS  PubMed  Google Scholar 

  77. 77.•

    Colrain I, Crowley K, Nicholas C, Padilla M, Baker F. The impact of alcoholism on sleep evoked Delta frequency responses. Biol Psychiatry. 2009;66(2):177–84. This study showed that alterations in sleep physiology may occur early in abstinence.

  78. 78.•

    Colrain I, Padilla M, Baker F. Partial recovery of alcohol dependence-related deficits in sleep evoked potentials following 12 months of abstinence. Front Neurol. 2012:313. This study showed that alterations in sleep physiology may occur in prolonged abstinence.

  79. 79.

    Cardenas V, Studholme C, Gardzinski S, Durazzo T, Meyerhoff D. Deformation based morphometry of brain changes in alcohol dependence and abstinence. Neuroimage. 2007;34:879–87.

    Article  PubMed Central  PubMed  Google Scholar 

  80. 80.

    O’Neill J, Cardenas V, Meyerhoff D. Effects of abstinence on the brain: quantitative magnetic resonance imaging and magnetic resonance spectroscopic imaging in chronic alcohol abuse. Alcohol Clin Exp Res. 2001;25:1673–82.

    Article  PubMed  Google Scholar 

  81. 81.

    Pfefferbaum A, Sullivan E, Mathalon D, Shear P, Rosenbloom M, Lim K. Longitudinal changes inmagnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcohol Clin Exp Res. 1995;19:1177–91.

    Article  CAS  PubMed  Google Scholar 

  82. 82.

    Babson K, Boden M, Bonn-Miller M. The impact of perceived sleep quality and sleep efficiency/duration on cannabis use during a self-guided quit attempt. Addict Behav. 2013;38:2707–13.

    Article  PubMed  Google Scholar 

  83. 83.•

    Babson K, Boden M, Bonn-Miller M. Sleep quality moderates the relation between depression symptoms and problematic cannabis use among medical cannabis users. Am Drug Alcohol Abus. 2013;39(3):211–6. This study was the first to show that poor sleep quality and low mood negatively impacts ability quit marijuana use.

    Article  Google Scholar 

  84. 84.•

    Babson K, Boden M, Harris A, Stickle T, Bonn-Miller M. Poor sleep quality as a risk factor for lapse following a cannabis quit attempt. J Subst Abus Treat. 2013;44:438–43. This study was the first to show that poor sleep quality negatively impacts ability quit marijuana use.

    Article  Google Scholar 

  85. 85.

    Budney AJ, Moore BA, Vandrey RG, Hughes JR. The time course and significance of cannabis withdrawal. J Abnorm Psychol. 2003;112(3):393–402.

    Article  PubMed  Google Scholar 

  86. 86.

    Budney A, Hughes J, Moore B, Vandrey R. Review of the validity and significance of cannabis withdrawal syndrome. Am J Psychiatry. 2004;161(11):1967–77.

    Article  PubMed  Google Scholar 

  87. 87.

    Copersino M, Boyd S, Tashkin D, Huestis M, Heishman S, Dermand J. Quitting among non-treatment-seeking marijuana users: reasons and changes in other substance use. Am J Addict. 2006;15(4):297–302.

    Article  PubMed  Google Scholar 

  88. 88.

    Bolla K, Lesage S, Gamaldo C, Neubauer D, Wang N, Funderburk F, et al. Polysomnogram changes in marijuana users who report sleep disturbances during prior abstinence. Sleep Med. 2010;11(9):882–9.

    Article  PubMed Central  PubMed  Google Scholar 

  89. 89.

    Haney M, Hart C, Vosburg S, Comer S, Reed S, Foltin R. Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse. Psychopharmacology. 2008;197(1):157–68.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  90. 90.

    Budney AJ, Hughes JR, Moore BA, Novy PL. Marijuana abstinence effects in marijuana smokers maintained in their home environment. Arch Gen Psychiatry. 2001;58(10):917–24.

    Article  CAS  PubMed  Google Scholar 

  91. 91.

    Brower KJ. Insomnia, alcoholism and relapse. Sleep Med Rev. 2003;7(6):523–39.

    Article  PubMed  Google Scholar 

  92. 92.

    Howland R. Gabapentin for Substance Use Disorders: Is it Safe and Appropriate? J Psychosoc Nurs Ment Health Serv. 2014:1-4.

  93. 93.

    Brower K, Kim HM, Strobbe S, Karam-Hage M, Consens F, Zucker R. A randomized double-blind pilot trial of gabapentin versus placebo to treat alcohol dependence and comorbid insomnia. Alcohol Clin Exp Res. 2008;32(8):1–10.

    Google Scholar 

  94. 94.

    Friedmann P, Rose J, Swift R, Stout R, Millman R, Stein M. Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial. Alcohol Clin Exp Res. 2008;32(9):1652–60.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  95. 95.

    Anton R, Myrick H, Wright T, Latham P, Baros A, Waid L, et al. Gabapentin combined with naltrexone for the treatment of alcohol dependence. Am J Psychiatry. 2011;168(7):709–17.

    Article  PubMed Central  PubMed  Google Scholar 

  96. 96.

    Monnelly E, Ciraulo D, Knapp C, LoCastro J, Sepulvda I. Quetiapine for treatment of alcohol dependence. J Clin Psychopharmacol. 2004;24:532–5.

    Article  CAS  PubMed  Google Scholar 

  97. 97.

    Chakravorty S, Hanlon A, Kuna S, Ross R, Kampman K, Witte L et al. The Effects of Quetiapine on Sleep in Recovering Alcohol-Dependent Subjects: A Pilot Study. J Clin Psychopharmacol. 2014.

  98. 98.

    Brower K, Conroy D, Kurth M, Stein M. Ramelteon and Improved Insomnia in Alcohol-Dependent Patients: A Case Series. J Clin Sleep Med. 2011;7(3):274–5.

    PubMed Central  PubMed  Google Scholar 

  99. 99.

    Grosshans M, Mutschler J, Luderer M, Mann K, Kiefer F. Agomelatine is effective in reducing insomnia in abstinent alcohol-dependent patients. Clin Neuropharmacol. 2014;37(1):6–8.

    CAS  PubMed  Google Scholar 

  100. 100.

    Currie SR, Clark S, Hodgins DC, el-Guebaly N. Randomized controlled trial of brief cognitive-behavioural interventions for insomnia in recovering alcohlics. Addiction. 2004;99:1121–32.

    Article  PubMed  Google Scholar 

  101. 101.

    Arnedt JT, Conroy D, Rutt J, Aloia MS, Brower KJ, Armitage R. An open trial of cognitive-behavioral treatment for insomnia comorbid with alcohol dependence. Sleep Med. 2007;8(2):176–80.

    Article  PubMed  Google Scholar 

  102. 102.

    Arnedt J, Conroy D, Armitage R, Brower K. Cognitive-behavioral therapy for insomnia in alcohol dependent patients: a randomized controlled pilot trial. Behav Res Ther. 2011;49(4):227–33.

    Article  PubMed Central  PubMed  Google Scholar 

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Deirdre A. Conroy and J. Todd Arnedt declare that they have no conflict of interest.

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This article is part of the Topical Collection on Sleep Disorders

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Conroy, D.A., Arnedt, J.T. Sleep and Substance Use Disorders: An Update. Curr Psychiatry Rep 16, 487 (2014). https://doi.org/10.1007/s11920-014-0487-3

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Keywords

  • Sleep latency (SL)
  • Wake after sleep onset (WASO)
  • Total sleep time (TST)
  • Sleep efficiency (SE; TST/time between “lights out” and “lights on”)
  • Percentages of stages 1 (S1%), 2 (S2%), 3 (S3%), 4 (S4%), Slow wave activity (SWA)
  • Slow wave sleep (SWS%)
  • Rapid eye movement (REM%) Sleep
  • REM latency (REM-L; duration between “sleep onset” and “REM onset”)