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Predicting Suicidal Behavior: Are We Really that Far Along? Comment on “Discovery and Validation of Blood Biomarkers for Suicidality”

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Abstract

A recent publication focused on biomarkers of future suicidal behaviors identifies several genes expressed in high-risk states among four samples. We discuss the implications of this study as well as the current state of research regarding biomarkers of suicidal behavior.

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References

  1. Le-Niculescu H, Levey DF, Ayalew M, Palmer L, Gavrin LM, Jain N, et al. Discovery and validation of blood biomarkers for suicidality. Mol Psychiatry. 2013. doi:10.1038/mp.2013.95.

    PubMed  Google Scholar 

  2. Smith EG, Kim HM, Ganoczy D, Stano C, Pfeiffer PN, Valenstein M. Suicide risk assessment received prior to suicide death by Veterans Health Administration patients with a history of depression. J Clin Psychiatry. 2013;74:226–32.

    Article  PubMed  Google Scholar 

  3. Isometsa ET, Heikkinen ME, Marttunen MJ, Henriksson MM, Aro HM, Lonnqvist JK. The last appointment before suicide: is suicide intent communicated? Am J Psychiatry. 1995;152:919–22.

    PubMed  CAS  Google Scholar 

  4. Pokorny A. Prediction of suicide in psychiatric patients: report of a prospective study. Arch Gen Psychiatry. 1983;40:249–57.

    Article  PubMed  CAS  Google Scholar 

  5. Blasco-Fontecilla H, Delgado-Gomez D, Ruiz-Hernandez D, Aguado D, Baca-Garcia E, Lopez-Castroman J. Combining scales to assess suicide risk. J Psychiatr Res. 2012;46(10):1272–7. doi:10.1016/j.jpsychires.2012.06.013.

    Article  PubMed  Google Scholar 

  6. Blasco-Fontecilla H, Delgado-Gomez D, Legido-Gil T, de Leon J, Perez-Rodriguez MM, Baca-Garcia E. Can the Holmes-Rahe Social Readjustment Rating Scale (SRRS) be used as a suicide risk scale? An exploratory study. Arch Suicide Res. 2012;16:13–28.

    Article  PubMed  Google Scholar 

  7. Baca-Garcia E, Parra CP, Perez-Rodriguez MM, Diaz-Sastre C. Reyes Torres R, Saiz-Ruiz J, de Leon J: Psychosocial stressors may be strongly associated with suicide attempts. Stress Health. 2007;23:191–8.

    Article  Google Scholar 

  8. Oquendo MA, Perez-Rodriguez MM, Poh E, Sullivan G, Burke AK, Sublette ME, et al. Life events: a complex role in the timing of suicidal behavior among depressed patients. Mol Psychiatry. 2013. doi:10.1038/mp.2013.128.

    PubMed  Google Scholar 

  9. Coryell W, Schlesser M. The dexamethasone suppression test and suicide prediction. Am J Psychiatry. 2001;158:748–53.

    Article  PubMed  CAS  Google Scholar 

  10. Sublette ME, Hibbeln JR, Galfalvy H, Oquendo MA, Mann JJ. Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk. Am J Psychiatry. 2006;163:1100–2.

    Article  PubMed  Google Scholar 

  11. Lee BH, Kim YK. Potential peripheral biological predictors of suicidal behavior in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:842–7.

    Article  PubMed  CAS  Google Scholar 

  12. Fiori LM, Bureau A, Labbe A, Croteau J, Noel S, Merette C, et al. Global gene expression profiling of the polyamine system in suicide completers. Int J Neuropsychopharmacol. 2011;14:595–605.

    Article  PubMed  CAS  Google Scholar 

  13. Brower V. Biomarkers: Portents of malignancy. Nature. 2011;471(7339):S19–21.

    Article  PubMed  CAS  Google Scholar 

  14. Jones R. Biomarkers: casting the net wide. Nature. 2010;466(7310):S11–2.

    Article  PubMed  CAS  Google Scholar 

  15. Fan J, Upadhye S, Worster A. Understanding receiver operating characteristic (ROC) curves. CJEM. 2006;8:19–20.

    PubMed  Google Scholar 

  16. Giner L, Blasco-Fontecilla H, Mercedes Perez-Rodriguez M, Garcia-Nieto R, Giner J, Guija JA, et al. Personality disorders and health problems distinguish suicide attempters from completers in a direct comparison. J Affect Disord. 2013;151:474–83.

    Article  PubMed  Google Scholar 

  17. Meyer RE, Salzman C, Youngstrom EA, Clayton PJ, Goodwin FK, Mann JJ, et al. Suicidality and risk of suicide–definition, drug safety concerns, and a necessary target for drug development: a brief report. J Clin Psychiatry. 2010;71:1040–6.

    Article  PubMed  Google Scholar 

  18. Gerszten RE, Wang TJ. The search for new cardiovascular biomarkers. Nature. 2008;451(7181):949–52.

    Article  PubMed  CAS  Google Scholar 

  19. Oquendo MA, Baca-Garcia E, Artes-Rodriguez A, Perez-Cruz F, Galfalvy HC, Blasco-Fontecilla H, et al. Machine learning and data mining: strategies for hypothesis generation. Mol Psychiatry. 2012;17:956–9.

    Article  PubMed  CAS  Google Scholar 

  20. Hampton T. Depression care effort brings dramatic drop in large HMO population's suicide rate. JAMA. 2010;303:1903–5.

    Article  PubMed  CAS  Google Scholar 

  21. Troister T, Links PS, Cutcliffe J. Review of predictors of suicide within 1 year of discharge from a psychiatric hospital. Curr Psychiatry Rep. 2008;10:60–5.

    Article  PubMed  Google Scholar 

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Conflict of Interest

Hilario Blasco-Fontecilla has received lecture fees from Eli Lilly, AB-Biotics, and Shire.

Jorge Lopez-Castroman, Lucas Giner, Enrique Baca-Garcia declare that they have no conflict of interest. Maria A. Oquendo has received unrestricted educational grants and/or lecture fees form AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Janssen, Otsuka, Pfizer, Sanofi-Aventis, and Shire. She receives royalties from the commercial use of the C-SSRS, and her family owns stock in Bristol-Myers Squibb.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Correspondence to Maria A. Oquendo.

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Blasco-Fontecilla, H., Lopez-Castroman, J., Giner, L. et al. Predicting Suicidal Behavior: Are We Really that Far Along? Comment on “Discovery and Validation of Blood Biomarkers for Suicidality”. Curr Psychiatry Rep 15, 424 (2013). https://doi.org/10.1007/s11920-013-0424-x

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  • DOI: https://doi.org/10.1007/s11920-013-0424-x

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