Skip to main content

Advertisement

Log in

Behavioral Disturbance in Dementia

  • Geriatric Disorders (DC Steffens, Section Editor)
  • Published:
Current Psychiatry Reports Aims and scope Submit manuscript

Abstract

Behavioral disturbances are frequently the most challenging manifestations of dementia and are exhibited in almost all people with dementia. Common behavioral disturbances can be grouped into four categories: mood disorders (e.g., depression, apathy, euphoria); sleep disorders (insomnia, hypersomnia, night–day reversal); psychotic symptoms (delusions and hallucinations); and agitation (e.g., pacing, wandering, sexual disinhibition, aggression). They are often persistent, greatly diminish quality of life of patients and their family caregivers, cause premature institutionalization, and pose a high economic burden on the patient, family, and society. Behavioral disturbances can be prevented and treated with a multifaceted approach that supports dignity and promotes comfort and quality of life of persons with dementia and their family members. Management involves prompt treatment of reversible factors and management of symptoms using primarily individualized nonpharmacological interventions. Pharmacological interventions need to be restricted to behavioral emergencies and for short-term treatment of behavioral disturbances that pose imminent danger to self or others.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. • Alzheimer’s Association. Alzheimer’s disease facts and figures. Alzheimers Dement. 2012;8:131–68. This reference provide the latest and most comprehensive statistics on prevalence of Alzheimer’s disease and behavioral disturbances.

    Google Scholar 

  2. Alzheimer’s Disease International. World Alzheimer Report 2010. London, Alzheimer’s Disease International; 2010. http://www.alz.co.uk/research/world-report. Accessed 6 April 2012.

  3. Lyketsos CG, Steinberg M, Tschanz JT, et al. Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging. Am J Psychiatry. 2000;157:708–14.

    PubMed  CAS  Google Scholar 

  4. Steinberg M, Shao H, Zandi P, et al. Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study. Int J Geriatr Psychiatry. 2008;23:170–7.

    PubMed  Google Scholar 

  5. Wetzels RB, Zuidema SU, de Jonghe JF, et al. Course of neuropsychiatric symptoms in residents with dementia in nursing homes over 2-year period. Am J Geriatr Psychiatry. 2010;18:1054–65.

    PubMed  Google Scholar 

  6. Wetzels R, Zuidema S, Jansen I, et al. Course of neuropsychiatric symptoms in residents with dementia in long-term care institutions: a systematic review. Int Psychogeriatr. 2010;22:1040–53.

    PubMed  Google Scholar 

  7. Bergh S, Engedal K, Roen I, Selbaek G. The course of neuropsychiatric symptoms in patients with dementia in Norwegian nursing homes. Int Psychogeriatr. 2011;23:1231–9.

    PubMed  Google Scholar 

  8. Borroni B, Agosti C, Padovani A. Behavioral and psychological symptoms in dementia with Lewy-bodies (DLB): Frequency and relationship with disease severity and motor impairment. Arch Gerontol Geriatrics. 2008;46:101–6.

    CAS  Google Scholar 

  9. Rabinovici GD, Miller BL. Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS Drugs. 2010;24:375–98.

    PubMed  CAS  Google Scholar 

  10. Moorhouse P, Rockwood K. Vascular cognitive impairment: current concepts and clinical development. Lancet Neurol. 2008;7:246–55.

    PubMed  Google Scholar 

  11. Robottom BJ, Weiner WJ. Dementia in Parkinson’s disease. Int Rev Neurobiol. 2009;84:229–44.

    PubMed  CAS  Google Scholar 

  12. Rossor MN, Fox NC, Mummery CJ, Schott JM, Warren JD. The diagnosis of young-onset dementia. Lancet Neurol. 2010;9:793–806.

    PubMed  Google Scholar 

  13. Rosenblatt A, Samus QM, Steele CD, et al. The Maryland assisted living study: prevalence, recognition, and treatment of dementia and other psychiatric disorders in the assisted living population of central Maryland. J Am Geriatr Soc. 2004;52:1618–25.

    PubMed  Google Scholar 

  14. Jost BC, Grossberg GT. The evolution of psychiatric symptoms in Alzheimer’s disease: a natural history study. J Am Geriatr Soc. 1996;44:1078–81.

    PubMed  CAS  Google Scholar 

  15. Lyketsos CG, Lopez O, Jones B, et al. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA. 2002;288:1475–83.

    PubMed  Google Scholar 

  16. Apostolova LG, Cummings JL. Neuropsychiatric manifestations in mild cognitive impairment. A systematic review of the literature. Dement Geriatr Cogn Disord. 2008;25:115–26.

    PubMed  Google Scholar 

  17. Sultzer DL, Levin HS, Mahler ME, et al. A comparison of psychiatric symptoms in vascular dementia and Alzheimer’s disease. Am J Psychiatry. 1993;150:1806–12.

    PubMed  CAS  Google Scholar 

  18. Forsell Y, Winblad B. Major depression in a population of demented and nondemented older people: Prevalence and correlates. J Am Geriatr Soc. 1998;46:27–30.

    PubMed  CAS  Google Scholar 

  19. McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65:1863–72.

    PubMed  CAS  Google Scholar 

  20. Tucker I. Management of inappropriate sexual behaviors in dementia: a literature review. Int Psychogeriatr. 2010;22:683–92.

    PubMed  Google Scholar 

  21. Chow TW, Binns MA, Cummings JL, et al. Apathy symptom profile and behavioral associations in frontotemporal vs. Alzheimer’s disease. Arch Neurol. 2009;66:888–93.

    PubMed  Google Scholar 

  22. Robert PH, Clairet S, Benoit M, et al. The Apathy Inventory: assessment of apathy and awareness in Alzheimer’s disease, Parkinson’s disease and mild cognitive impairment. Int J Geriatr Psychiatry. 2002;17:1099–105.

    PubMed  CAS  Google Scholar 

  23. Srikanth S, Nagaraja AV, Ratnavalli E. Neuropsychiatric symptoms in dementia – frequency, relationship to dementia severity and comparison in Alzheimer’s disease, vascular dementia and frontotemporal dementia. J Neurol Sci. 2005;236:43–8.

    PubMed  CAS  Google Scholar 

  24. Steffens DC, Otey E, Alexopoulos GS, et al. Perspectives on depression, mild cognitive impairment, and cognitive decline. Arch Gen Psychiatry. 2006;63:130–8.

    PubMed  Google Scholar 

  25. Rubin EH, Veiel LL, Kinscherf DA, et al. Clinically significant depressive symptoms in very mild to mild dementia of the Alzheimer’s type. Int J Geriatr Psychiatry. 2001;16:694–701.

    PubMed  CAS  Google Scholar 

  26. Baldini-Gruber A, Zimmerman S, Boustani M, et al. Characteristics associated with depression in long-term care residents with dementia. Gerontologist. 2005;45:50–5.

    Google Scholar 

  27. Lyketsos CG, Steele C, Galik E, et al. Physical aggression in dementia patients and its relationship to depression. Am J Psychiatry. 1999;156:66–71.

    PubMed  CAS  Google Scholar 

  28. Cummings JL. Behavioral and neuropsychiatric outcomes in Alzheimer’s disease. CNS Spectr. 2005;10 Suppl 18:22–5.

    PubMed  Google Scholar 

  29. Hoe J, Hancock G, Livingston G, Orrell M. Quality of Life of people with dementia in residential care homes. Br J Psychiatry. 2006;188:460–4.

    PubMed  CAS  Google Scholar 

  30. Selbaek G, Engedal K. Stability of the factor structure of the Neuropsychiatric Inventory in a 31-month follow-up study of a large sample of nursing-home patients with dementia. Int Psychogeriatr. 2012;24:62–73.

    PubMed  Google Scholar 

  31. Spalletta G, Musicco M. Padovani, et al. Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed, untreated patients with Alzheimer disease. Am J Geriatr Psychiatry. 2010;18:1026–35.

    PubMed  Google Scholar 

  32. Cohen-Mansfield J, Billig N. Agitated behaviors in the elderly: a conceptual review. J Am Geriatr Soc. 1986;34:711–21.

    PubMed  CAS  Google Scholar 

  33. Leonard R, Tinneti ME, Allore HG, et al. Potentially modifiable resident characteristics that are associated with physical or verbal aggression among nursing home residents with dementia. Arch Intern Med. 2006;166:1295–300.

    PubMed  Google Scholar 

  34. Robinson L, Hutchings D, Dickinson HO, et al. Effectiveness and acceptance of non-pharmacological interventions to reduce wandering in dementia: a systematic review. Int J Geriatr Psychiatry. 2007;22:9–22.

    PubMed  CAS  Google Scholar 

  35. Lantz M. Wandering in dementia. Clin Geriatrics. 2007;15:21–4.

    Google Scholar 

  36. Khachiyants N, Trinkle D, Son SJ, Kim KY. Sundown syndrome in persons with dementia: an update. Psychiatry Investig. 2011;8:275–87.

    PubMed  Google Scholar 

  37. Bombois S, Derambure P, Pasquire F, Monaca C. Sleep disorders in aging and dementia. J Nutr Health Aging. 2010;14:212–7.

    PubMed  CAS  Google Scholar 

  38. Boeve BF. REM Sleep Behavior Disorder: Update review of the core features, the RBD-Neurodegenerative Disease Association. Evolving concepts, controversies, and future directions. Ann N Y Acad Sci. 2010;1184:15–54.

    PubMed  CAS  Google Scholar 

  39. Ropacki S, Jeste D. Epidemiology of and risk factors for psychosis of Alzheimer’s disease: a review of 55 studies published from 1990 to 2003. Am J Psychiatry. 2005;162:2022–30.

    PubMed  Google Scholar 

  40. Johnson D, Watts A, Chapin B, et al. Neuropsychiatric profiles in dementia. Alzheimer Dis Assoc Disord. 2011;25:326–32.

    PubMed  Google Scholar 

  41. Bassiony MM, Lyketsos CG. Delusions and hallucinations in Alzheimer’s Disease: review of the brain decade. Psychosomatics. 2003;44:388–401.

    PubMed  Google Scholar 

  42. Woods DL, Phillips LR, Martin JL. Biological basis for sleep disturbance and behavioral symptoms in dementia: a biobehavioral model. Res Gerontol Nurs. 2011;4:281–93.

    PubMed  Google Scholar 

  43. Zarros AC, Kalopita KS, Tsakiris ST. Serotoninergic impairment and aggressive behavior in Alzheimer’s disease. Acta Neurobiol Exp (Wars). 2005;65:277–86.

    Google Scholar 

  44. Day K, Carreon D, Stump C. The therapeutic design of environments for people with dementia: a review of the empirical research. Gerontologist. 2000;40:397–416.

    PubMed  CAS  Google Scholar 

  45. Cummings JL, Back C. The cholinergic hypothesis of neuropsychiatric symptoms in Alzheimer’s disease. Am J Geriatr Psychiatry. 1998;6 Suppl 1:64–8.

    Google Scholar 

  46. Lancot KL, Hermann N, van Reekum R, et al. Gender, aggression and serotonergic function are associated with response to sertraline for behavioral disturbances in Alzhiemer’s disease. Int J Geriatr Psychiatry. 2002;17:531–41.

    Google Scholar 

  47. Baldessarini RJ, March ER, Kula NS. Interactions of fluoxetine with metabolism of dopamine and serotonin in rat brain regions. Brain Res. 1992;579:152–6.

    PubMed  CAS  Google Scholar 

  48. Zubenko GS, Moossy J, Martinez J, et al. Neurropatholic and neurochemical correlates of psychosis in primary dementia. Arch Neurol. 1991;48:619–24.

    PubMed  CAS  Google Scholar 

  49. Lopez OL, Smith G, Becker JT, et al. The psychotic phenomenon in probable Alzhiemer’s disease: a positron emission tomography study. J Neuropsychiatry Clin Neurosci. 2001;13:50–5.

    PubMed  CAS  Google Scholar 

  50. Marra C, Quaranta D, Profice P, et al. Central cholinergic dysfunction measured “in vivo” correlates with different behavioral disorders in Alzheimer’s disease and dementia with Lewy body. Brain Stimul. 2011. doi:10.1016/j.brs.2011.08.009.

  51. Holmes C, Smith H, Ganderton R, et al. Psychosis and aggression in Alzhiemer’s disease: the effect of dopamine receptor gene variation. J Neurol Neurosurg Psychiatry. 2001;71:777–9.

    PubMed  CAS  Google Scholar 

  52. Sukonick DL, Pollock BG, Sweet RA, et al. The 5-HTTPR *S/*L polymorphism and aggressive behavior in Alzheimer’s disease. Arch Neurol. 2001;58:1425–8.

    PubMed  CAS  Google Scholar 

  53. Cohen-Mansfield J, Marx MS, Freedman LS, et al. The Comprehensive Process Model of Engagement. Am J Geriatr Psychiatry. 2011;19:859–70.

    PubMed  Google Scholar 

  54. Pitfield C, Shahriyarmolki K, Livingston G. A systematic review of stress in staff caring for people with dementia living in 24-hour care settings. Int Psychogeriatr. 2011;23:4–9.

    PubMed  Google Scholar 

  55. Orrell M, Hancock GA, Galboda KC, et al. The needs of people with dementia in care homes: the perspectives of users, staff and family caregivers. Int Psychogeriatr. 2008;20:941–51.

    PubMed  Google Scholar 

  56. van der Roest HG, Meiland FJM, Maroccini R, et al. Subjective needs in people with dementia: a review of the literature. Int Psychogeriatr. 2007;19:559–92.

    PubMed  Google Scholar 

  57. Luo H, Lin M, Castle N. Physical restraint use and falls in nursing homes: A comparison between residents with and without dementia. Am J Alzheimers Dis Other Demen. 2011;26:44–50.

    PubMed  Google Scholar 

  58. Scherder EJA, Bogen T, Eggermont LHP, et al. The more physical inactivity, the more agitation in dementia. Int Psychogeriatr. 2010;22:1203–8.

    PubMed  Google Scholar 

  59. Wang WW, Moyle W. Physical restraint use on people with dementia. A review of literature. Aust J Adv Nurs. 2005;22:46–52.

    PubMed  Google Scholar 

  60. Ballard C, Fossey J, Chithramohan R, et al. Quality of care in people with dementia in private sector and NHS facilities for people with dementia: cross sectional survey. BMJ. 2001;323:426–7.

    PubMed  CAS  Google Scholar 

  61. Morley J. Dementia-related agitation. JAMDA. 2011;12:611–2.

    Google Scholar 

  62. Desai AK. Psychotropic side effects of commonly prescribed drugs in the elderly. Primary Psychiatry. 2004;11:27–34.

    Google Scholar 

  63. Fick DM, Agostini JV, Inouye SK. Delirium superimposed on dementia: A systematic review. J Am Geriatr Soc. 2002;50:1723–32.

    PubMed  Google Scholar 

  64. Buffum MD, Hutt E, Chang VT, et al. Cognitive impairment and pain management: Review of issues and challenges. J Rehabil Res Dev. 2007;44:315–30.

    PubMed  Google Scholar 

  65. Bourbonnais A, Ducharme F. The meanings of screams in older people living with dementia in a nursing home. Int Psychogeriatr. 2010;22:1172–84.

    PubMed  Google Scholar 

  66. Koppel J, Goldberg TE, Gordon ML, et al. Relationships between behavioral syndromes and cognitive domains in Alzheimer’s disease: the impact of mood and psychosis. Am J Geriatr Psychiatry. 2011. doi:10.1097/JGP.0b013e3182358921

  67. Steele C, Rovner B, Chase GA, Folstein M. Psychiatric symptoms and nursing home placement of patients with Alzheimer’s disease. Am J Psychiatry. 1990;147:1049–51.

    PubMed  CAS  Google Scholar 

  68. Mohamed S, Rosenheck R, Lyketsos CG, Schneider LS. Caregiver burden in Alzheimer disease: cross-sectional and longitudinal patient correlates. Am J Geriatr Psychiatry. 2010;18:917–27.

    PubMed  Google Scholar 

  69. Hermann N, Lanctot KL, Sambrook R, et al. The contribution of neuropsychiatric symptoms to the cost of dementia care. Int J Geriatr Psychiatry. 2006;21:972–6.

    Google Scholar 

  70. Matsumoto N, Ikeda M, Fukuhara R, et al. Caregiver burden associated with behavioral and psychological symptoms of dementia in elderly people in the local community. Dement Geriatr Cogn Disord. 2007;23:219–24.

    PubMed  Google Scholar 

  71. Craig D, Mirakhur A, Hart DJ, et al. A cross sectional study of neuropsychiatric symptoms in 435 patients with Alzheimer’s disease. Am J Geriatr Psychiatry. 2005;13:460–8.

    PubMed  Google Scholar 

  72. Stern Y, Tang MX, Albert SM, et al. Predicting time to nursing home care and death in individuals with Alzheimer disease. JAMA. 1997;227:806–12.

    Google Scholar 

  73. Bergvall N, Brinck P, Eek D, et al. Relative importance of patient disease indicators on informal care and caregiver burden in Alzheimer’s disease. Int Psychogeriatr. 2011;23:73–85.

    PubMed  Google Scholar 

  74. Svanberg E, Spector A, Stott J. The impact of young onset dementia on the family: a literature review. Int Psychogeriatr. 2011;23:356–71.

    PubMed  Google Scholar 

  75. Lee DR, Thomas AJ. Sleep in dementia and caregiving – assessment and treatment implications: a review. Int Psychogeriatr. 2011;23:190–201.

    PubMed  Google Scholar 

  76. O’Donnell BF, Drachman DA, Barnes HJ, et al. Incontinence and troublesome behaviors predict institutionalization in dementia. J Geriatr Psychiatry Neurol. 1992;5:45–52.

    PubMed  Google Scholar 

  77. Miller EA, Schneider LS, Rosenheck RA. Predictors of nursing home admission among Alzheimer’s disease patients with psychosis and/or agitation. Int Psychogeriatr. 2011;23:44–53.

    PubMed  Google Scholar 

  78. Chung JCC, Lai CKY. Elopement among community-dwelling older adults with dementia. Int Psychogeriatr. 2011;23:65–72.

    PubMed  Google Scholar 

  79. Coen RF, Swanwick GR, O’Boyle CA, Coakley D. Behaviour disturbances and other predictors of carer burden in Alzheimer’s disease. Int J Geriatr Psychiatry. 1997;12:331–6.

    PubMed  CAS  Google Scholar 

  80. Kaufer DI, Cummings JL, Christine D, et al. Assessing the impact of neuropsychiatric symptoms in Alzheimer’s disease: the Neuropsychiatric Inventory Caregiver Distress Scale. J Am Geriatr Soc. 1998;46:210–5.

    PubMed  CAS  Google Scholar 

  81. Beeri MS, Werner P, Davidson M, Noy S. The cost of behavioral and psychological symptoms of dementia (BPSD) in community dwelling Alzheimer’s disease patients. Int J Geriatr Psychiatry. 2002;17:403–8.

    PubMed  Google Scholar 

  82. Grossberg GT, Desai AK. Management of Alzheimer’s disease. J Gerontol Med Sci. 2003;58A:331–53.

    CAS  Google Scholar 

  83. Passmore MJ, Ho A, Gallagher R. Behavioral and psychological symptoms in moderate to severe Alzheimer’s disease: A palliative care approach emphasizing recognition of personhood and preservation of dignity. J Alzheimer Dis. 2012;29:1–13.

    Google Scholar 

  84. • Gauthier S, Cummings J, Ballard C, et al. Management of behavioral problems in Alzheimer’s disease. Int Psychogeriatr. 2010;22:346–72. A most recent review on the management of behavioral disturbances in patients with Alzheimer’s disease.

    PubMed  Google Scholar 

  85. Lyketsos CG, Carrillo MC, Ryan JM, et al. Neuropsychiatric symptoms in Alzheimer’s disease. Alzheimer Dement. 2011;7:532–9.

    Google Scholar 

  86. Koopmans RTC, Zuidema SU, Leontjevas R, Gerritsen DL. Comprehensive assessment of depression and behavioral problems in long-term care. Int Psychogeriatr. 2010;23:1054–62.

    Google Scholar 

  87. Desai AK, Grossberg GT. Management of Alzheimer’s disease. J Gerontol Med Sci. 2003;58A:331–53.

    Google Scholar 

  88. Cummings JL, Mega M, Gray K, et al. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44:2308–14.

    PubMed  CAS  Google Scholar 

  89. Reisberg B, Borenstein J, Salob SP, et al. Behavioral symptoms in Alzheimer’s disease: phenomenology and treatment. J Clin Psychiatry. 1987;48:9–15.

    PubMed  Google Scholar 

  90. Jeon YH, Sansoni J, Low LF, et al. Recommended measures for the assessment of behavioral disturbances associated with dementia. Am J Geriatr Psychiatry. 2011;19:403–15.

    PubMed  Google Scholar 

  91. Alexopoulos GS, Abrams RC, Young RC, et al. Cornell scale for depression in dementia. Biol Psychiatry. 1988;23:271–84.

    PubMed  CAS  Google Scholar 

  92. •• American Geriatrics Society: Guide to the management of psychotic disorders and neuropsychiatric symptoms associated with dementia in older adults. http://dementia.americangeriatrics.org/GeriPsych_index.php. Accessed 8 February 2012. Latest and most comprehensive approach to management of behavioral disturbances in patients with dementia.

  93. Rabins PV, Blacker D, Rovner BW, et al. APA Work Group on Alzheimer’s Disease and other Dementias. American Psychiatric Association practice guidelines for the treatment of patients with Alzheimer’s disease and other dementias. Second edition. Am J Psychiatry. 2007;164 Suppl 12:5–56.

    PubMed  Google Scholar 

  94. Cohen-Mansfield L, Libin A, Marx MS. Nonpharmacological treatment of agitation: a controlled trial of systematic individualized intervention. Gerontol A Biol Sci Med Sci. 2007;62:908–16.

    Google Scholar 

  95. Manepalli J, Desai A, Sharma P. Psychosocial-environmental treatments for Alzheimer’s disease. Primary Psychiatry. 2009;16:39–47.

    Google Scholar 

  96. Edwardsson D, Winblad B, Sandman PO. Person centered care of people with severe Alzheimer’s disease: Current status and ways forward. Lancet Neurol. 2008;7:362–7.

    Google Scholar 

  97. O’Neil ME, Freeman M, Christensen V, et al. A systematic evidence review of non-pharmacological interventions for behavioral symptoms of dementia. VA Evidence-based Synthesis Program Reports. 2011.

  98. Tune LE. Nonpharmacological treatment of inappropriate sexual behaviors in dementia: the case of the Pink Panther. Am J Geriatr Psychiatry. 2008;16:612–6.

    PubMed  Google Scholar 

  99. Olazaran J, Reisberg B, Clare L, et al. Nonpharmacological therapies in Alzheimer’s disease: A systematic review of efficacy. Dement Geritr Cogn Disord. 2010;30:161–78.

    Google Scholar 

  100. Vernooij-Dassen M, Vasse E, Zuidema S, et al. Psychosocial interventions for dementia patients in long-term care. Int Psychogeriatr. 2010;22:1121–8.

    PubMed  Google Scholar 

  101. •• Kverno KS, Black BS, Nolan MT, Rabin PV. Research on treating neuropsychiatric symptoms of advanced dementia with non-pharmacological strategies, 1998–2008: a systematic literature review. Int Psychogeriatr. 2009;21:825–43. Excellent review of the literature on the efficacy of non-pharmacological strategies for the treatment of behavioral disturbances in patients with advanced dementia.

    PubMed  Google Scholar 

  102. Forbes D, Culum I, Lischka AR, et al. Light therapy for managing cognitive, sleep, functional behavioural, or psychiatric disturbances in dementia. Cochane Database Syst Rev. 2009;(4):CD003946.

  103. der Lek RF Riemersma-van, Swaab DF, Twisk J, et al. Effect of bright light and melatonin on cognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA. 2008;299:2642–55.

    Google Scholar 

  104. Mossello E, Ridolfi A, Mello AM, et al. Animal-assisted activity and emotional status of patients with Alzheimer’s disease in day care. Int Psychogeriatr. 2011;23:899–905.

    Google Scholar 

  105. Smith M, Kolanowski A, Buettner LL, Buckwalter KC. Beyond bingo: meaningful activities for persons with dementia in nursing homes. Ann Long Term Care. 2009;17:22–30.

    Google Scholar 

  106. Kolanowski A, Fick D, Waller JL, Ahern F. Outcomes of antipsychotic drug use in community-dwelling elders with dementia. Arch Psychiatr Nurs. 2006;20:217–25.

    PubMed  Google Scholar 

  107. Kovach CR, Taneli Y, Dohearty P, et al. Effect of the BACE intervention on agitation of people with dementia. Gerontologist. 2004;44:797–806.

    PubMed  Google Scholar 

  108. Graff MJL, Vernooij-Dassen MJM, Thijssen M, et al. Effects of community occupational therapy on quality of life, mood, and health status in dementia patients and their caregivers: a randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2007;62:1002–9.

    PubMed  Google Scholar 

  109. Volicer L, Simard J, Pupa JH, Medrek R, Riordan ME. Effects of continuous activity programming on the behavioral symptoms of dementia. J Am Med Direct Assoc. 2006;7:426–31.

    Google Scholar 

  110. Cohen-Mansfield J. Nonpharmacologic interventions for inappropriate behaviors in dementia: a review, summary and critique. Am J Geriatr Psychiatry. 2001;9:361–82.

    PubMed  CAS  Google Scholar 

  111. Teri L, Logsdon RG, Uomoto J, McCurry SM. Behavioral treatment of depression in dementia patients: a controlled clinical trial. J Gerontol Psychol Sci Soc Sci. 1997;52:159–66.

    Google Scholar 

  112. Chenoweth L, King MT, Jeon YH, et al. Caring for aged dementia care resident study (CADRES) of person-centered care, dementia-care mapping, and usual care in dementia: a cluster-randomized trial. Lancet Neurol. 2009;8:317–25.

    PubMed  Google Scholar 

  113. Landau R, Werner S. Ethical aspects of using GPS for tracking people with dementia: recommendations for practice. Int Psychogeriatr. 2012;24:358–66.

    PubMed  Google Scholar 

  114. Sloane PD, Hoeffer B, Mitchell CM, et al. Effect of person-centered showering and the towel bath on bathing-associated aggression, agitation, and discomfort in nursing home residents with dementia: A randomized controlled trial. J Am Geriatr Soc. 2004;52:1795–804.

    PubMed  Google Scholar 

  115. Rosenberg PB, Mielke MM, Han D, et al. The association of psychotropic medication use with the cognitive, functional, and neuropsychiatric trajectory of Alzheimer’s disease. Int J Geriatr Psychiatry. 2012. doi:10.1002/gps.3769

  116. Lavretsky H. Neuropsychiatric symptoms in Alzheimer’s disease and related dementias: Why do treatments work in clinical practice but not in the randomized trials. Am J Geriatr Psychiatry. 2008;16:523–7.

    PubMed  Google Scholar 

  117. Naarding P, van Grevenstein M, Beekman ATF. Benefit-risk analysis for the clinician: “primum non nocere” revisited – the case for antipsychotics in the treatment of behavioral disturbances in dementia. Int J Geriatr Psychiatry. 2010;25:437–40.

    PubMed  CAS  Google Scholar 

  118. Devanand DP, Schultz SK. Consequences of antipsychotic medications for the dementia patient. Am J Psychiatry. 2011;168:767–9.

    PubMed  CAS  Google Scholar 

  119. Horstink M, Tolosa E, Bonuccelli U, et al. Review of the therapeutic management of Parkinson’s Disease. Report of a joint task force of the European Federation of Neurological Society (EFNS) and the Movement Disorder Society – European Section (MDS-ES). Part II: late (complicated) Parkinson’s disease. Eur J Neurol. 2006;13:1186–202.

    PubMed  CAS  Google Scholar 

  120. Wilcock GK, Ballard CG, Cooper JA, Loft H. Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer’s disease: a pooled analysis of 3 studies. J Clin Psychiatry. 2008;69:341–8.

    PubMed  CAS  Google Scholar 

  121. Kerchner GA, Tartaglia MC, Boxer A. Abhorring the vacuum: use of Alzheimer’s disease medications in frontotemporal dementia. Expert Rev Neurother. 2011;11:709–17.

    PubMed  Google Scholar 

  122. Howard RJ, Juszczak E, Ballard CG, et al. CALM-AD Trial Group: Donepezil for the treatment of agitation in Alzheimer’s disease. N Engl J Med. 2007;357:1382–92.

    PubMed  CAS  Google Scholar 

  123. Cummings JL, Schneider L, Tariot PN, et al. Reduction of behavioral disturbances and caregiver distress by galantamine in patients with Alzheimer’s disease. Am J Psychiatry. 2004;161:532–8.

    PubMed  Google Scholar 

  124. Vidal JS, et al. Evaluation of the impact of Memantine treatment initiation on psychotropics use: a study from the French national health care database. Neuroepidemiology. 2008;31:193–200.

    PubMed  Google Scholar 

  125. Bannerjee S, Hellier J, Dewey M, et al. Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomized, multicenter, double-blind, placebo-controlled trial. Lancet. 2011;378:403–11.

    Google Scholar 

  126. Nelson JC, Devanand DP. A systematic review and meta-analysis of placebo-controlled antidepressant studies in people with depression and dementia. J Am Geriatr Soc. 2011;59:577–85.

    PubMed  Google Scholar 

  127. Brodaty H. Antidepressant treatment in Alzheimer’s Disease. Lancet. 2011;378:375–6.

    PubMed  Google Scholar 

  128. Seitz DP, Adunuri N, Gill SS, et al. Antidepressants for agitation and psychosis in dementia. Cochrane Database Syst Rev. 2011;(2):CD008191.

  129. Barak Y, Plopski I, Tadger S, Paleacu D. Escitalopram versus risperidone for the treatment of behavioral and psychotic symptoms associated with Alzheimer’s disease: a randomized double-blind pilot study. Int Psychogeriatr. 2011;23:1515–9.

    Google Scholar 

  130. • Henry G, Williamson D, Tampi RR. Efficacy and tolerability of antidepressants in the treatment of behavioral and psychological symptoms of dementia, a literature review of evidence. Am J Alzheimers Dis Other Demen. 2011;26:169–83. Excellent review of evidence for the use of antidepressants to treat behavioral disturbances in patients with dementia.

    PubMed  Google Scholar 

  131. Hermann N, Black SE, Chow T, et al. Serotonergic function and treatment of behavioral and psychological symptoms of frontotemporal dementia. Am J Geriatr Psychiatry. 2011. doi:10.1097/JGP.0b013e31823033f3

  132. Wood LD, Neumiller JJ, Setter SM. Dobbins. Clinical review of treatment options for select nonmotor symptoms of Parkinson’s disease. Am J Geriatr Pharmacother. 2010;8:294–315.

    PubMed  CAS  Google Scholar 

  133. Culo S, Mulsant BH, Rosen J, et al. Treating neuropsychiatric symptoms in dementia with lewy bodies: a randomized controlled-trial. Alzheimer Dis Assoc Disord. 2010;24:360–4.

    Google Scholar 

  134. Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA. 2005;19:1934–43.

    Google Scholar 

  135. Schneider LS, Dagerman K, Insel PS. Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials. Am J Geriatr Psychiatry. 2006;14:191–210.

    PubMed  Google Scholar 

  136. US Food and Drug Administration. Deaths with antipsychotics in elderly patients with behavioral disturbances. Silver Spring: US Food and Drug Administration, Public Health Advisory, Center for Drug Evaluation and Research; 2005.

    Google Scholar 

  137. Jeste DV, Blazer D, Casey D, et al. ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia. Neuropsychopharmacology. 2008;33:957–70.

    PubMed  CAS  Google Scholar 

  138. Kales HC, Kim HM, Zivin K, et al. Risk of mortality among individual antipsychotics in patients with dementia. Am J Psychiatry. 2011;168:71–9.

    Google Scholar 

  139. Wang PS, Schneeweiss S, Avorn J, et al. Risk of death in elderly users of conventional vs. atypical antipsychotic medications. N Engl J Med. 2005;353:2335–41.

    PubMed  CAS  Google Scholar 

  140. Huybrechts KF, Rothman KJ, Silliman RA, et al. Risk of death and hospital admission for major medical events after initiation of psychotropic medications in older adults admitted to nursing homes. CMAJ. 2010;183:E411–9.

    Google Scholar 

  141. Vigen CLP, Mack WJ, Keefe RSE, et al. Cognitive effects of atypical antipsychotic medications in patients with Alzheimer’s Disease: Outcomes From CATIE-AD. Am J Psychiatry. 2011;168:831–9.

    PubMed  Google Scholar 

  142. Knol W, Marum RJV, Jansen PAF, et al. Antipsychotic drug use and risk of pneumonia in elderly people. J Am Geriatr Soc. 2008;56:661–6.

    PubMed  Google Scholar 

  143. Ballard C, Hanney ML, Theodoulou M, et al. For the DART-AD investigators. The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomized placebo-controlled trial. Lancet Neurol. 2009;8:151–7.

    PubMed  CAS  Google Scholar 

  144. Sultzer DL, Davis SM, Tariot PN, et al. CATIE-AD Study Group. Clinical symptom responses to atypical antipsychotic medications in Alzheimer’s disease: phase 1 outcomes from the CATIE-AD effectiveness trial. Am J Psychiatry. 2008;165:844–54.

    PubMed  Google Scholar 

  145. Zheng L, Mack WJ, Dagerman KS, et al. Metabolic changes associated with second-generation antipsychotic use in Alzheimer’s disease patients: the CATIE-AD study. Am J Psychiatry. 2009;166:583–90.

    PubMed  Google Scholar 

  146. Devanand DP, Pelton GH, Cunqueiro K, Sackeim HA, Marder K. A 6-month, randomized, double-blind, placebo-controlled pilot discontinuation trial following response to haloperidol treatment of psychosis and agitation in Alzheimer’s disease. Int J Geriatr Psychiatry. 2011;26:937–43.

    PubMed  CAS  Google Scholar 

  147. Leon C, Gerretsen P, Uchida H, et al. Sensitivity to antipsychotic drugs in older adults. Curr Psychiatry Rep. 2010;12:28–33.

    PubMed  Google Scholar 

  148. Corbett A, Ballard C. Antipsychotics and mortality in dementia. Am J Psychiatry. 2011;169:7–9.

    Google Scholar 

  149. Profenno LA, Tariot PN. Pharmacologic management of agitation in Alzhiemer’s disease. Dement Geriatr Cogn Disord. 2004;17:65–77.

    PubMed  Google Scholar 

  150. Llorente M, Urrutia V. Diabetes, psychiatric disorders, and the metabolic effects of antipsychotic medications. Clin Diabetes. 2006;24:18–24.

    Google Scholar 

  151. Baskys A. Lewy body dementia: the litmus test for neuroleptic sensitivity and extrapyramidal symptoms. J Clin Psychiatry. 2004;65 Suppl 11:16–22.

    PubMed  Google Scholar 

  152. Mitchell SL, Teno JM, Kiely DK, et al. The clinical course of advanced dementia. N Engl J Med. 2009;361:1529–38.

    PubMed  CAS  Google Scholar 

  153. Dolder CR, Nealy KL, McKinsey J. Valproic acid in dementia: does an optimal dose exist? J Pharm Pract. 2012;25:142–50.

    PubMed  Google Scholar 

  154. Olin JT, Fox LS, Pawluczyk S, et al. A pilot randomized trial of carbamazepine for behavioral symptoms in treatment-resistant outpatients with Alzheimer disease. Am J Geriatr Psychiatry. 2001;9:400–5.

    PubMed  CAS  Google Scholar 

  155. Tariot PN, Erb R, Podgorski CA, et al. Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. Am J Psychiatry. 1998;155:54–61.

    PubMed  CAS  Google Scholar 

  156. Sommer BR, Fenn HH, Ketter TA. Safety and efficacy of anticonvulsants in elderly patients with psychiatric disorders: oxcarbamazepine, topiramate and gabapentin. Expert Opin Drug Saf. 2007;6:133–45.

    PubMed  CAS  Google Scholar 

  157. Kim Y, Wilkins KM, Tampi RR. Use of gabapentin in the treatment of behavioral and psychological symptoms of dementia: a review of the evidence. Drugs Aging. 2008;25:187–96.

    PubMed  CAS  Google Scholar 

  158. Ng B, Camacho A, Bardwell W, et al. Lamotrigine for agitation in older patients with dementia. Int Psychogeriatr. 2009;21:207–8.

    PubMed  Google Scholar 

  159. Kushnir SL. Lithium-antidepressant combinations in the treatment of depressed, physically ill geriatric patients. Am J Psychiatry. 1986;143:378–9.

    PubMed  CAS  Google Scholar 

  160. Teri L, et al. Alzheimer’s Disease Cooperative Study: Treatment of agitation in AD: a randomized, placebo-controlled clinical trial. Neurology. 2000;55:1271–8.

    PubMed  CAS  Google Scholar 

  161. Lawlor BA, Radcliffe J, Molchan SA, et al. A pilot placebo-controlled study of trazodone and buspirone in Alzheimer’s disease. Int J Geriatr Psychiatry. 1994;9:55–9.

    Google Scholar 

  162. Stevenson DG, Decker SL, Dwyer LL, et al. Antipsychotic and benzodiazepine use among nursing home residents: findings from the 2004 National Nursing Home Survey. Am J Geriatr Psychiatry. 2010;18:1078–92.

    PubMed  Google Scholar 

  163. Bourgeois J, Elseviers MM, Azermai M, et al. Benzodiazepine use in Belgian nursing homes: a closer look into indications and dosages. Eur J Clin Pharmacol. 2012;68:833–44.

    PubMed  CAS  Google Scholar 

  164. Neugroschl J, Wang S. Alzheimer’s Disease: Diagnosis and treatment across the spectrum of disease severity. Mt Sinai J Med. 2011;78:596–612.

    PubMed  Google Scholar 

  165. Wang LY, Shofer JB, Rohde K, et al. Prazosin for the treatment of behavioral symptoms in Alzheimer’s disease patients with agitation and aggression. Am J Geriatr Psychiatry. 2009;17:744–51.

    PubMed  Google Scholar 

  166. Peskind ER, Tsuang DW, Bonner LT, et al. Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study. Alzheimer Dis Assoc Disord. 2005;19:23–8.

    PubMed  CAS  Google Scholar 

  167. Kraus MF, Maki PM. Effect of amantadine hydrochloride on symptoms of frontal lobe dysfunction in brain injury: case studies and review. J Neuropsychiatry Clin Neurosci. 1997;9:222–30.

    PubMed  CAS  Google Scholar 

  168. Kyomen HH, Satlin A, Hennen J, et al. Estrogen therapy and aggressive behavior in elderly patients with moderate-to-severe dementia: results from a short-term, randomized double-blind trial. Am J Geriatr Psychiatry. 1999;7:339–48.

    PubMed  CAS  Google Scholar 

  169. Desai AK, Grossberg GT. Buspirone in Alzheimer’s disease. Exp Rev Neurother. 2003;3:19–28.

    CAS  Google Scholar 

  170. Gehrman PR, Connor DJ, Martin JL, et al. Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer’s disease. Am J Geriatr Psychiatry. 2009;17:166–9.

    PubMed  Google Scholar 

  171. Rao V, Lyketsos CG. The benefits and risks of ECTs for patients with primary dementia who also suffer from depression. Int J Geriatr Psychiatry. 2000;15:729–35.

    PubMed  CAS  Google Scholar 

  172. Ujkaj M, Davidoff DA, Seiner SJ, et al. Safety and efficacy of electroconvulsive therapy for the treatment of agitation and aggression in patients with dementia. Am J Geriatr Psychiatry. 2012;20:61–72.

    PubMed  Google Scholar 

  173. Salzman C, Jeste DV, Meyer RE, et al. Elderly patients with dementia-related symptoms of severe agitation and aggression: consensus statement on treatment options, clinical trials methodology, and policy. J Clin Psychiatry. 2008;69:889–98.

    PubMed  Google Scholar 

  174. Husebo BS, Ballard C, Aarsland D. Pain treatment of agitation in patients with dementia: a systematic review. Int J Geriatr Psychiatry. 2011;26:1012–8.

    PubMed  CAS  Google Scholar 

  175. Hori K, Konishi K, Watanabe K, et al. Influence of anticholinergic activity in serum on clinical symptoms of Alzheimer’s disease. Neuropsychobiology. 2011;63:147–53.

    PubMed  CAS  Google Scholar 

Download references

Disclosure

Dr Desai and Dr Schwartz reported no potential conflicts of interest relevant to this article.

Dr Grossberg has served as a consultant for Baxter, Forest Laboratories, Merck, and Novartis, and has received research funding from Baxter, Bristol-Myers Squibb, Forest Laboratories, Janssen, National Institutes of Health (NIH), Novartis, and Pfizer. Dr Grossberg has received payment for the development of educational presentations from Novartis; has had travel/accommodations expenses covered/reimbursed by Merck and Novartis; has received payment for serving on safety monitoring commissions for Abbot and Merck.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Abhilash K. Desai.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Desai, A.K., Schwartz, L. & Grossberg, G.T. Behavioral Disturbance in Dementia. Curr Psychiatry Rep 14, 298–309 (2012). https://doi.org/10.1007/s11920-012-0288-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11920-012-0288-5

Keywords

Navigation