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Nonaffective Acute Psychoses: Uncertainties on the Way to DSM-V and ICD-11

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Abstract

Since the early 20th century, a group of nonaffective psychoses with acute onset and brief duration have been described in different countries under various names, including cycloid psychosis, bouffée délirante, and reactive psychosis. These psychoses share several characteristics, including benign course, greater prevalence in women than men and in developing countries than in industrialized countries, and high prevalence of premorbid psychological and physiologic stressors. However, the variations in names and minute details of symptomatology have overshadowed the basic similarities across these various descriptions. Confusion in classification persists in the two contemporary diagnostic systems, the DSM-IV and the ICD-10. We believe that most cases of these psychoses could be captured under a broad, unified category of nonaffective psychosis with acute onset and brief duration, and urge the authors of the upcoming revisions of the DSM and ICD to create such a category. A unified diagnostic category for these disorders would reduce unnecessary fragmentation in the diagnostic systems and assist in the progress of research on these rare conditions.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Pillmann F, Marneros A. Brief and acute psychoses: the development of concepts. Hist Psychiatry. 2003;14(2):161.

    Article  PubMed  CAS  Google Scholar 

  2. Mojtabai R. Acute and transient psychotic disorders and brief psychotic disorder. In: Kaplan VA, Sadock BJ, editors. Comprehensive textbook of psychiatry. 8th ed. Philadelphia: Lippincott; 2005. p. 1512–22.

    Google Scholar 

  3. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (Revised 4th ed.). Washington, DC: American Psychiatric Association; 2000.

    Book  Google Scholar 

  4. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. World Health Organization Geneva; 1993.

  5. •• Marneros A, Pillmann F. Acute and Transient Psychoses. Cambridge: Cambridge University Press; 2004. Excellent review of the history of ATPD and related concepts. Provides a comprehensive summary of research related to all aspects of these disorders, including risk factors, course, treatment and outcome.

    Book  Google Scholar 

  6. Perris C, Brockington IF. Cycloid psychoses and their relation to the major psychoses. In: Perris C, Struwe G, & Jansson B, editors. Biological Psychiatry. Amsterdam: Elsevier; 1981;447–450.

  7. Leonhard K. Classification of endogenous psychoses and their differential etiology. In: Beckmann H, Cahn CH, editors. 2nd ed. Springer; 1999.

  8. Perris C. A study of cycloid psychoses. Acta Psychiatr Scand. 1974;50(s253):7–79.

    Article  Google Scholar 

  9. Pichot P. The concept of ‘bouffée délirante’ with special reference to the Scandinavian concept of reactive psychosis. Psychopathology. 1986;19(1–2):35–43.

    Article  PubMed  CAS  Google Scholar 

  10. Weibel H, Metzger JY. Psychoses délirantes aiguės. EMC-Psychiatrie. 2005;2(1):40–61.

    Article  Google Scholar 

  11. Opjordsmoen S. Reactive psychosis and other brief psychotic episodes. Curr Psychiatry Rep. 2001;3(4):338–41.

    Article  PubMed  CAS  Google Scholar 

  12. Jauch DA, Carpenter Jr WT. Reactive psychosis I: does the pre-DSM-III concept define a third psychosis? J Nerv Ment Dis. 1988;176(2):72.

    Article  PubMed  CAS  Google Scholar 

  13. Susser E, Wanderling J. Epidemiology of nonaffective acute remitting psychosis vs schizophrenia: sex and sociocultural setting. Arch Gen Psychiatry. 1994;51(4):294.

    PubMed  CAS  Google Scholar 

  14. • Castagnini A, Berrios GE. Acute and transient psychotic disorders (ICD-10 F23): a review from a European perspective. Eur Arch Psychiatry Clin Neurosci. 2009;259(8):433–443. This is a recent review of ATPD disorders and the concordance of older concepts (cycloid psychosis and bouffée délirante) with the new ATPD classification system. The authors argue that ATPD is not a valid diagnosis due to the poor diagnostic stability over time.

    Article  PubMed  Google Scholar 

  15. Pillmann F, Haring A, Balzuweit S, Blöink R, Marneros A. Concordance of acute and transient psychoses and cycloid psychoses. Psychopathology. 2001;34:305.

    Article  PubMed  CAS  Google Scholar 

  16. Ngoma M, Vansteelandt K, Delespaul P, Krabbendam L, Miezi SMM, Peuskens J. Cognitive deficits in nonaffective functional psychoses: a study in the Democratic Republic of Congo. Psychiatry Res. 2010;180(2–3):86–92.

    Google Scholar 

  17. • Arranz B, San L, Ramírez N, Dueñas RM, Perez V, Salavert J, et al. Clinical and serotonergic predictors of non-affective acute remitting psychosis in patients with a first-episode psychosis. Acta Psychiatr.Scand. 2009;119(1):71–77. This was an interesting study comparing NARP and schizophrenia patients. Patients with NARP had a lower number of 5-HT 2A receptors, better premorbid adjustment, fewer hallucinations, and shorter duration of untreated psychosis.

    Article  PubMed  CAS  Google Scholar 

  18. Alaghband-Rad J, Boroumand M, Amini H, Sharifi V, Omid A, Davari-Ashtiani R, et al. Non–affective acute remitting psychosis: a preliminary report from Iran. Acta Psychiatr Scand. 2006;113(2):96–101.

    Article  PubMed  CAS  Google Scholar 

  19. Mojtabai R, Susser ES, Bromet EJ. Clinical characteristics, 4-year course, and DSM-IV classification of patients with nonaffective acute remitting psychosis. Am J Psychiatry. 2003;160(12):2108.

    Article  PubMed  Google Scholar 

  20. Cutting J. Relationship between cycloid psychosis and typical affective psychosis. Psychopathology. 1990;23(4–6):212–9.

    Article  PubMed  CAS  Google Scholar 

  21. Jamison KR. Atypical cycloid psychoses. In: Friedmann CTH, Faguet RA, editors. Extraordinary Disorders of Human Behavior, Plenum: New York; 1982:259–291.

  22. Mojtabai R. Heterogeneity of cycloid psychoses: a latent class analysis. Psychol Med. 2000;30(03):721–6.

    Article  PubMed  CAS  Google Scholar 

  23. Singh SP, Burns T, Amin S, Jones PB, Harrison G. Acute and transient psychotic disorders: precursors, epidemiology, course and outcome. Br J Psychiatry. 2004;185(6):452.

    Article  PubMed  Google Scholar 

  24. •• Castagnini A, Bertelsen A, Berrios GE. Incidence and diagnostic stability of ICD-10 acute and transient psychotic disorders. Compr.Psychiatry 2008;49(3):255–261. This was a 6-year follow-up study of patients with an ATPD diagnosis using the Danish registry. The authors reported on incidence, readmission, diagnostic stability, and predictors of good outcome.

    Article  PubMed  Google Scholar 

  25. Lindvall M, Axelsson R, Ohman R. Incidence of cycloid psychosis. A clinical study of first-admission psychotic patients. Eur Arch Psychiatry Clin Neurosci. 1993;242(4):197–202.

    Article  PubMed  CAS  Google Scholar 

  26. Lindvall M, Hagnell O, Ohman R. Epidemiology of cycloid psychosis. A prospective longitudinal study of incidence and risk in the 1947 cohort of the Lundby study. Eur Arch Psychiatry Neurol Sci. 1986;236(2):109–18.

    Article  PubMed  CAS  Google Scholar 

  27. Perala J, Suvisaari J, Saarni SI, Kuoppasalmi K, Isometsa E, Pirkola S, et al. Lifetime prevalence of psychotic and bipolar I disorders in a general population. Arch Gen Psychiatry. 2007;64(1):19.

    Article  PubMed  Google Scholar 

  28. Malhotra S, Varma VK, Malhotra A. Classification of acute nonorganic psychotic states in India. Int J Ment Health. 1992;21:16–6.

    Google Scholar 

  29. Cooper JE, Jablensky A, Sartorius N. WHO collaborative studies on acute psychoses using the SCAAPS schedule. In: Stefanis CN et al. editors. Psychiatry: a world perspective, Vol. 1. Classification and psychopathology, child psychiatry, substance use. (International congress series) Excerpta Medica: Amsterdam; 1990:185–192.

  30. Tandon R, Keshavan MS, Nasrallah HA. Schizophrenia, Just the facts: what we know in 2008. 2. Epidemiology and etiology. Schizophr Res. 2008;102(1–3):1–18.

    Article  PubMed  Google Scholar 

  31. McGrath J, Saha S, Welham J, El Saadi O, MacCauley C, Chant D. A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC Med. 2004;2:13.

    Article  PubMed  Google Scholar 

  32. Marneros A, Pillmann F, Haring A, Balzuweit S, Blöink R. Features of acute and transient psychotic disorders. Eur Arch Psychiatry Clin Neurosci. 2003;253(4):167–74.

    Article  PubMed  Google Scholar 

  33. Manton KG, Korten A, Woodbury MA, Anker M, Jablensky A. Symptom profiles of psychiatric disorders based on graded disease classes: an illustration using data from the WHO International Pilot Study of Schizophrenia. Psychol Med. 1994;24(01):133–44.

    Article  PubMed  CAS  Google Scholar 

  34. Das SK, Malhotra S, Basu D, Malhotra R. Testing the stress–vulnerability hypothesis in ICD–10–diagnosed acute and transient psychotic disorders. Acta Psychiatr Scand. 2001;104(1):56–8.

    Article  PubMed  CAS  Google Scholar 

  35. Alexandre J, Ribeiro R, Cardoso G. Ethnic and clinical characteristics of a Portuguese psychiatric inpatient population. Transcult Psychiatry. 2010;47(2):314.

    Article  PubMed  Google Scholar 

  36. Franzek E, Becker T, Hofmann E, Flöhl W, Stöber G, Beckmann H. Is computerized tomography ventricular abnormality related to cycloid psychosis? Biol Psychiatry. 1996;40(12):1255–66.

    Article  PubMed  CAS  Google Scholar 

  37. Susser E, Fennig S, Jandorf L, Amador X, Bromet E. Epidemiology, diagnosis, and course of brief psychoses. Am J Psychiatry. 1995;152(12):1743.

    PubMed  CAS  Google Scholar 

  38. Sajith SG, Chandrasekaran R, Sadanandan Unni KE, Sahai A. Acute polymorphic psychotic disorder: diagnostic stability over 3 years. Acta Psychiatr Scand. 2002;105(2):104–9.

    Article  PubMed  CAS  Google Scholar 

  39. Collins PY, Wig NN, Day R, Varma VK, Malhotra S, Misra AK, et al. Psychosocial and biological aspects of acute brief psychoses in three developing country sites. Psychiatr Q. 1996;67(3):177–93.

    Article  PubMed  CAS  Google Scholar 

  40. Jørgensen P, Bennedsen B, Christensen J, Hyllested A. Acute and transient psychotic disorder: comorbidity with personality disorder. Acta Psychiatr Scand. 1996;94(6):460–4.

    Article  PubMed  Google Scholar 

  41. Malhotra S, Varma VK, Misra AK, Das S, Wig NN, Santosh PJ. Onset of acute psychotic states in India: a study of sociodemographic, seasonal and biological factors. Acta Psychiatr Scand. 1998;97(2):125–31.

    Article  PubMed  CAS  Google Scholar 

  42. Pfuhlmann B, Stöber G, Franzek E, Beckmann H. Cycloid psychoses predominate in severe postpartum psychiatric disorders. J Affect Disord. 1998;50(2–3):125–34.

    Article  PubMed  CAS  Google Scholar 

  43. Lau PWL, Cheng JGY, Chow DLY, Ungvari GS, Leung CM. Acute psychiatric disorders in foreign domestic workers in Hong Kong: a pilot study. Int J Soc Psychiatry. 2009;55(6):569.

    Article  PubMed  Google Scholar 

  44. Littlewood R, Lipsedge M. Acute psychotic reactions in Caribbean-born patients. Psychol Med. 1981;11(02):303–18.

    Article  PubMed  CAS  Google Scholar 

  45. Guinness EA. Brief reactive psychosis and the major functional psychoses: descriptive case studies in Africa. Br J Psychiatry Suppl. 1992;(16):24–41.

  46. Das SK, Malhotra S, Basu D. Family study of acute and transient psychotic disorders: comparison with schizophrenia. Soc Psychiatry Psychiatr Epidemiol. 1999;34(6):328–32.

    Article  PubMed  CAS  Google Scholar 

  47. Franzek E, Beckmann H. Different genetic background of schizophrenia spectrum psychoses: a twin study. Am J Psychiatry. 1998;155(1):76.

    PubMed  CAS  Google Scholar 

  48. Collins PY, Varma VK, Wig NN, Mojtabai R, Day R, Susser E. Fever and acute brief psychosis in urban and rural settings in north India. Br J Psychiatry. 1999;174(6):520.

    Article  PubMed  CAS  Google Scholar 

  49. Stöber G, Kocher I, Franzek E, Beckmann H. First–trimester maternal gestational infection and cycloid psychosis. Acta Psychiatr Scand. 1997;96(5):319–24.

    Article  PubMed  Google Scholar 

  50. Jørgensen P, Bennedsen B, Christensen J, Hyllested A. Acute and transient psychotic disorder: a 1–year follow–up study. Acta Psychiatr Scand. 1997;96(2):150–4.

    Article  PubMed  Google Scholar 

  51. Pillmann F, Blöink R, Balzuweit S, Haring A, Marneros A. Personality and social interactions in patients with acute brief psychoses. J Nerv Ment Dis. 2003;191(8):503.

    Article  PubMed  Google Scholar 

  52. Mojtabai R, Susser E, Varma V. Duration of remitting psychoses with acute onset: implications for ICD-10. Br J Psychiatry. 2000;176(6):576.

    Article  PubMed  CAS  Google Scholar 

  53. • Möller HJ, Jäger M, Riedel M, Obermeier M, Strauss A, Bottlender R. The Munich 15-year follow-up study (MUFUSSAD) on first-hospitalized patients with schizophrenic or affective disorders: comparison of psychopathological and psychosocial course and outcome and prediction of chronicity. Eur Arch Psychiatry Clin Neurosci. 2010;260:367–384. This was a 15-year follow-up study of patients with ATPD. The study provides a good presentation of results regarding course and diagnostic stability.

  54. Susser E, Varma VK, Mattoo SK, et al. Long-term course of acute brief psychosis in a developing country setting. Br J Psychiatry. 1998;173(3):226.

    Article  PubMed  CAS  Google Scholar 

  55. Amini H, Alaghband-Rad J, Omid A, et al. Diagnostic stability in patients with first-episode psychosis. Australas Psychiatry. 2005;13(4):388–92.

    PubMed  Google Scholar 

  56. Chang WC, Pang SLK, Chung DWS, Chan SSM. Five-year stability of ICD-10 diagnoses among Chinese patients presented with first-episode psychosis in Hong Kong. Schizophr Res. 2009;115(23):351–7.

    Article  PubMed  Google Scholar 

  57. Abe T, Otsuka K, Kato S. Long-term clinical course of patients with acute polymorphic psychotic disorder without symptoms of schizophrenia. Psychiatry Clin Neurosci. 2006;60(4):452–7.

    Article  PubMed  Google Scholar 

  58. Suda K, Hayashi N, Hiraga M. Predicting features of later development of schizophrenia among patients with acute and transient psychotic disorder. Psychiatry Clin Neurosci. 2005;59(2):146–50.

    Article  PubMed  Google Scholar 

  59. Castagnini AC, Bertelsen A. Mortality and causes of death of acute and transient psychotic disorders. Soc Psychiatry Psychiatr Epidemiol. 2010:1–5. [Epub ahead of print], doi:10.1007/s00127-010-0276-1

  60. Pillmann F, Balzuweit S, Haring A, Blöink R, Marneros A. Suicidal behavior in acute and transient psychotic disorders. Psychiatry Res. 2003;117(3):199–209.

    Article  PubMed  Google Scholar 

  61. Thomas P, Alptekin K, Gheorghe M, Mauri M, Olivares JM, Riedel M. Management of patients presenting with acute psychotic episodes of schizophrenia. CNS Drugs. 2009;23(3):193–212.

    Article  PubMed  CAS  Google Scholar 

  62. Gaebel W, Weinmann S, Sartorius N, Rutz W, McIntyre JS. Schizophrenia practice guidelines: international survey and comparison. Br J Psychiatry. 2005;187(3):248.

    Article  PubMed  Google Scholar 

  63. Jablensky A. Classification of nonschizophrenic psychotic disorders: a historical perspective. Curr Psychiatry Rep. 2001;3(4):326–31.

    Article  PubMed  CAS  Google Scholar 

  64. Susser E, Finnerty MT, Sohler N. Acute psychoses: a proposed diagnosis for ICD-11 and DSM-V. Psychiatr Q. 1996;67(3):165–76.

    Article  PubMed  CAS  Google Scholar 

  65. Pillmann F, Haring A, Balzuweit S, Blöink R, Marneros A. The concordance of ICD-10 acute and transient psychosis and DSM-IV brief psychotic disorder. Psychol Med. 2002;32(03):525–33.

    Article  PubMed  CAS  Google Scholar 

  66. Gurland BJ, Fleiss JL, Sharpe L, Roberts P, Cooper JE, Kendell RE. Cross-national study of diagnosis of mental disorders: hospital diagnoses and hospital patients in New York and London. Compr Psychiatry. 1970;11(1):18–25.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This work was supported in part by National Institute of Mental Health grant no. 5T32MH014592.

Disclosure

Dr. Mojtabai has received grant support from Bristol-Myers Squibb. Ms. Nugent and Ms. Paksarian reported no potential conflicts of interest relevant to this article.

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Correspondence to Ramin Mojtabai.

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Nugent, K.L., Paksarian, D. & Mojtabai, R. Nonaffective Acute Psychoses: Uncertainties on the Way to DSM-V and ICD-11 . Curr Psychiatry Rep 13, 203–210 (2011). https://doi.org/10.1007/s11920-011-0190-6

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