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HIV in adolescents: What we know and what we need to know

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Abstract

HIV, the cause of AIDS, has infected more than 65 million people worldwide, including 1 million children. An estimated 39.5 million people are living with HIV. As of 2006, 4.3 million were newly infected, with 2.8 million occurring in sub-Saharan Africa. Rates of infection have risen more than 50% in Eastern Europe and Central Asia. Mother-to-child transmission occurs rarely with antiretroviral treatments in the United States, and congenitally infected children are living to adulthood. HIV is now a “youth-driven disease” worldwide. In the United States, 40% of new HIV infections occur in individuals less than 25 years old, and HIV is the sixth-leading cause of death among adolescents. Young people with HIV/AIDS live with this chronic condition and its associated medical and psychological morbidities while coping with identity and maturation issues. In this paper, we review what we know about HIV and psychiatric disorders among adolescents.

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References and Recommended Reading

  1. US Department of Health and Human Services, Centers for Disease Control and Prevention: HIV/AIDS Surveillance Report 2003, vol 15. Atlanta: Centers for Disease Control and Prevention; 2004:1–40. http://www.cdc.gov/hiv/stats/hasrlink.htm Accessed January 14, 2008.

    Google Scholar 

  2. US Department of Health and Human Services, Centers for Disease Control and Prevention: HIV/AIDS among youth. In HIV/AIDS Surveillance Report 2004, vol 16. Atlanta: Centers for Disease Control and Prevention; 2005:1–46. http://www.cdc.gov/hiv/topics/surveillance/resources/reports/2004report. Accessed January 14, 2008.

    Google Scholar 

  3. Evans DL, Ten Have TR, Douglas SD, et al.: Association of depression with viral load, CD8 T lymphocytes, and natural killer cells in women with HIV infection. Am J Psychiatry 2002, 159:1752–1759.

    Article  PubMed  Google Scholar 

  4. Morrison MF, Petitto JM, Ten Have T, et al.: Depressive and anxiety disorders in women with HIV infection. Am J Psychiatry 2002, 159:789–796.

    Article  PubMed  Google Scholar 

  5. Kessler RC, McGonagle KA, Zhao S, et al.: Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 1994, 51:8–19.

    PubMed  CAS  Google Scholar 

  6. Fauci A, Lane HC: HIV disease: AIDS and related disorders. In Harrison’s Principles of Internal Medicine, edn 15. Edited by Braunwald E. New York: McGraw-Hill; 2001:1852–1913.

    Google Scholar 

  7. Grunbaum JA, Kann L, Kinchen S, et al.: Youth risk behavior surveillance—United States, 2003. MMWR Surveill Summ 2004, 53:1–96.

    PubMed  Google Scholar 

  8. Lehrer JA, Shrier LA, Gortmaker S: Depressive symptoms as a longitudinal predictor of sexual risk behaviors among US middle and high school students. Pediatrics 2006, 118:189–200.

    Article  PubMed  Google Scholar 

  9. Leserman J: HIV disease progression: depression, stress, and possible mechanisms. Biol Psychiatry 2003, 54:295–306.

    Article  PubMed  Google Scholar 

  10. Murphy DA, Durako SJ, Moscicki AB, et al.: No change in health risk behaviors over time among HIV infected adolescents in care: role of psychological distress. J Adolesc Health 2001, 29(3 Suppl):57–63.

    Article  PubMed  CAS  Google Scholar 

  11. Lightfoot M, Swendeman D, Rotheram-Borus MJ, et al.: Risk behaviors of youth living with HIV: pre-and post-HAART. Am J Health Behav 2005, 29:162–171.

    PubMed  Google Scholar 

  12. Murphy DA, Mosciki B, Vermund SH: Psychological distress among HIV+ adolescents in the REACH study: effects of life stress, social support and coping. J Adolesc Health 2000, 27:391–398.

    Article  PubMed  CAS  Google Scholar 

  13. Hein K, Dell K, Rotheram-Borus MJ, et al.: Comparison of HIV+ and HIV-adolescents: risk factors and psychosocial determinants. Pediatrics 1995, 95:96–104.

    PubMed  CAS  Google Scholar 

  14. Donenberg G, Pao M: Youths and HIV/AIDS: psychiatry’s role in a changing epidemic. J Am Acad Child Adolesc Psychiatry 2005, 44:728–747.

    Article  PubMed  Google Scholar 

  15. Donenberg G, Pao M: Understanding HIV/AIDS: psychosocial and psychiatric issues in youths. Contemp Psychiatry 2003, 2:1–8.

    Google Scholar 

  16. Brown LK, Lescano CM, Lourie KJ: Children and adolescents with HIV infection. Psychiatr Ann 2001, 31:63–68.

    Google Scholar 

  17. Lwin R, Melvin D: Paediatric HIV infection. J Child Psychol Psychiatry 2001, 42:427–438.

    Article  PubMed  CAS  Google Scholar 

  18. Mellins CA, Smith R, O’Driscoll P, et al.: High rates of behavioral problems in perinatally HIV-infected children are not linked to HIV disease. Pediatrics 2003, 111:384–393.

    Article  PubMed  Google Scholar 

  19. Scharko AM: DSM psychiatric disorders in the context of pediatric HIV/AIDS. AIDS Care 2006, 18:441–445.

    Article  PubMed  CAS  Google Scholar 

  20. Misdrahi D, Vila G, Funk-Brentano I, et al.: DSM-IV mental disorders and neurological complications in children and adolescents with human immunodeficiency virus type infection (HIV-1). Eur Psychiatry 2004, 19:182–184.

    Article  PubMed  CAS  Google Scholar 

  21. Gaughan DM, Hughes MD, Oleske JM, et al.: Psychiatric hospitalizations among children and youths with human immunodeficiency virus infection. Pediatrics 2004, 113:E544–E551.

    Article  PubMed  Google Scholar 

  22. Tardieu M, Chenadec JL, Persoz A: HIV-1-related encephalopathy in infants compared with children and adults. French Pediatric HIV Infection Study and the SEROCO group. Neurology 2000, 54:1089–1095.

    PubMed  CAS  Google Scholar 

  23. Watkins JM, Cool VA, Usner D, et al.: Attention in HIV-infected children: results from the Hemophilia Growth and Development Study. J Int Neuropsychol Soc 2000, 6:443–454.

    Article  PubMed  CAS  Google Scholar 

  24. Brown LK, Danokovsy MB, Lourie KJ: Adolescents with psychiatric disorders and the risk of HIV. J Am Acad Child Adolesc Psychiatry 1997, 36:1609–1617.

    Article  PubMed  CAS  Google Scholar 

  25. DiClemente RJ, Ponton LE: HIV-related risk behaviors among psychiatrically hospitalized adolescents and school-based adolescents. Am J Psychiatry 1993, 150:324–325.

    PubMed  CAS  Google Scholar 

  26. Deas-Nesmith D, Brady KT, White R, et al.: HIV-risk behaviors in adolescent substance abusers. J Subst Abuse Treat 1999, 16:169–172.

    Article  PubMed  CAS  Google Scholar 

  27. Tubman JG, Gil AG, Wagner EF, et al.: Patterns of sexual risk behaviors and psychiatric disorders in a community sample of young adults. J Behav Med 2003, 26:473–500.

    Article  PubMed  Google Scholar 

  28. Rotheram-Borus MJ, Mahler KA, Rosario M: AIDS prevention with adolescents. AIDS Educ Prev 1995, 7:320–336.

    PubMed  CAS  Google Scholar 

  29. Booth RE, Zhang YH: Conduct disorder and HIV risk behaviors among runaway and homeless adolescents. Drug Alcohol Depend 1997, 48:69–76.

    Article  PubMed  CAS  Google Scholar 

  30. Donenberg GR, Emerson E, Bryant FB, et al.: Understanding AIDS-risk behavior among adolescents in psychiatric care: links to psychopathology and peer relationships. J Am Acad Child Adolesc Psychiatry 2001, 40:642–653.

    Article  PubMed  CAS  Google Scholar 

  31. Brown L, Lourie K, Zlotnik C, et al.: Impact of sexual abuse on the HIV-related behavior of adolescents in intensive psychiatric treatment. Am J Psychiatry 2000, 157:1413–1415.

    Article  PubMed  CAS  Google Scholar 

  32. Guttmann LT, Herman-Giddens ME, McKinney RE, et al.: Pediatric acquired immunodeficiency syndrome: barriers to recognizing the role of child sexual abuse. Am J Dis Child 1993, 147:775–780.

    Google Scholar 

  33. Lindgren ML, Hanson IC, Hammett TA, et al.: Sexual abuse of children: intersection with the HIV epidemic. Pediatrics 1998, 102:E46.

    Article  Google Scholar 

  34. Lodico MA, DiClemente RJ: The association between childhood sexual abuse and prevalence of HIV-related risk behaviors. Clin Pediatr (Phila) 1994, 33:498–502.

    Article  CAS  Google Scholar 

  35. Murphy DA, Belzer M, Durako SJ, et al.: Longitudinal antiretroviral adherence among adolescents infected with human immunodeficiency virus. Arch Pediatr Adolesc Med 2005, 159:764–770.

    Article  PubMed  Google Scholar 

  36. Williams PL, Storm D, Montepiedra G, et al.: Predictors of adherence to antiretroviral medications in children and adolescents with HIV infection. Pediatrics 2006, 118:e1745–e1757.

    Article  PubMed  Google Scholar 

  37. Weiner L, Battles H, Ryder C, et al.: Psychotropic medication use in human immunodeficiency virus-infected youth receiving treatment at a single institution. J Child Adolesc Psychopharmacol 2006, 16:747–753.

    Article  Google Scholar 

  38. Evans DL, Charney DS, Lewis L, et al.: Mood disorders in the medically ill: scientific review and recommendations. Biol Psychiatry 2005, 58:175–189.

    Article  PubMed  Google Scholar 

  39. Dube B, Benton T, Cruess DG, Evans DL: Neuropsychiatric manifestations of HIV infection and AIDS. J Psychiatry Neurosci 2005, 30:237–246.

    PubMed  Google Scholar 

  40. Pieper AA, Treisman GJ: Drug treatment of depression in HIV-positive patients: safety considerations. Drug Saf 2005, 28:753–762.

    Article  PubMed  CAS  Google Scholar 

  41. Leserman J, DiSantostefano BS, Perkins DO: A longitudinal study of social support, and social conflict as predictors of depression and dysphoria among HIV-positive and HIV-negative gay men. Depression 1994, 2:189–199.

    Article  Google Scholar 

  42. Cruess DG, Douglas SD, Petitto JM, et al.: Association of resolution of major depression with increased natural killer cell activity among HIV-seropositive women. Am J Psychiatry 2005, 162:2125–2130.

    Article  PubMed  Google Scholar 

  43. Douglas SD, Camarco M, Xu J, et al.: The relationships between substance abuse, psychosocial variables, and natural killer cell enumeration and function in HIV infected and high-risk uninfected adolescents. AIDS Res Hum Retroviruses 2003, 19:399–408.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, University of Pennsylvania, The Children’s Hospital of Philadelphia, 3440 Market Street, Suite 200, Philadelphia, PA, 19104, USA

    Tami D. Benton

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  1. Tami D. Benton
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  2. Judith A. Ifeagwu
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Correspondence to Tami D. Benton.

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Benton, T.D., Ifeagwu, J.A. HIV in adolescents: What we know and what we need to know. Curr Psychiatry Rep 10, 109–115 (2008). https://doi.org/10.1007/s11920-008-0020-7

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