Current Psychiatry Reports

, Volume 9, Issue 4, pp 329–336 | Cite as

Dopamine hypothesis of schizophrenia: Making sense of it all

  • Mitsuru Toda
  • Anissa Abi-DarghamEmail author


The dopamine (DA) hypothesis of schizophrenia has evolved over the last decade from the stage of circumstantial evidence related to clinical observations and empirical validation from antipsychotic treatment to finally reach more direct testing and validation from imaging studies. These have provided much information that allows us at this point to assemble all the pieces and attempt to synthesize them and integrate them with the other neurotransmitter alterations observed in this illness. Although clearly not sufficient to explain the complexity of this disorder, the DA dysregulation offers a direct relationship to symptoms and to their treatment. We will review here its history, validation, and implications for treatment.


Nemonapride Renic Hetamine Depl Etion Opamine Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Authors and Affiliations

  1. 1.New YorkUSA

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