Current Psychiatry Reports

, Volume 6, Issue 4, pp 243–254 | Cite as

Genetics of anxiety disorders

  • Paul D. Arnold
  • Gwyneth Zai
  • Margaret A. Richter


There is considerable evidence that genetic determinants play a major role in the etiology of anxiety. Investigations into susceptibility genes for anxiety are well underway, particularly for panic disorder and obsessive-compulsive disorder and more broadly defined anxiety-related traits, such as neuroticism and harm avoidance. This review will discuss some of the core issues related to diagnosis and molecular genetic methodology, followed by a review of recent molecular genetic findings for anxiety. The authors will attempt to highlight the numerous convergent and exciting findings. Given the rapid acceleration in knowledge of the human genome, a more definitive understanding of the genetic roots of these complex conditions may be anticipated in the relatively near future.


Anxiety Disorder Panic Disorder Panic Disorder Harm Avoidance Myelin Oligodendrocyte Glycoprotein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Science Inc 2004

Authors and Affiliations

  • Paul D. Arnold
  • Gwyneth Zai
  • Margaret A. Richter
    • 1
  1. 1.Anxiety Disorders Clinic, Centre for Addiction and Mental HealthUniversity of TorontoTorontoCanada

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