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Emerging Medications and Strategies in Acute Pain Management: Evolving Role of Novel Sodium and Calcium Channel Blockers, Peptide-Based Pharmacologic Drugs, and Non-Medicinal Methods

  • Acute Pain Medicine (R Urman, Section Editor)
  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The present investigation evaluated integration of novel medication technology to enhance treatment options, while improving patient outcomes in acute pain management. In this regard, we focused on determining the role of development and utilization of cutting-edge pharmaceutical advancements, such as targeted drug delivery systems, as well as non-pharmacologic interventions in addressing acute pain states. Further research in this area is warranted related to the need for increased patient comfort and reduced adverse effects.

Recent Findings

Recent innovations and techniques are discussed including pharmacologic drugs targeting sodium and calcium channels, peptide-based pharmacologic drugs, and non-medicinal methods of alleviating pain such as soothing music or virtual reality.

Summary

The present investigation included review of current literature on the application of these innovative technologies, analyzing mechanisms of action, pharmacokinetics, and clinical effectiveness. Our study also investigated the potential benefits in terms of pain relief, reduced side effects, and improved patient adherence. The research critically examines the challenges and considerations associated with implementing these technologies in acute pain management, considering factors like cost, accessibility, and regulatory aspects. Additionally, case studies and clinical trials are highlighted which demonstrate practical implications of these novel medication technologies in real-world scenarios. The findings aim to provide healthcare professionals with a comprehensive understanding of the evolving landscape in acute pain management while guiding future research and clinical practices toward optimizing their use in enhancing patient care.

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Data Availability

No datasets were generated or analysed during the current study.

References

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Funding

No funding or sponsorship was received for this study or publication of this article.

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Authors and Affiliations

  1. Department of Anesthesiology, Department of Pharmacology, Toxicology, and Neurosciences, Louisiana State University Health Sciences Center, Shreveport, LA, 71103, USA

    Alan D. Kaye

  2. School of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, 71103, USA

    Driskell R. Greene, Amanda Ragland, Mason P. Granger, William Peyton Wilhite & Kylie Dufrene

  3. School of Medicine, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, 70112, LA, USA

    Catherine Nguyen

  4. Department of Anesthesiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71103, USA

    Sahar Shekoohi

  5. Beth Israel Deaconess Medical Center, Department of Anesthesiology, Critical Care, and Pain Medicine, Harvard Medical School, Boston, MA, 02215, USA

    Christopher L. Robinson

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  1. Alan D. Kaye
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  3. Catherine Nguyen
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  8. Sahar Shekoohi
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Contributions

Study concept, design, and writing: ADK, DRG, CN, AR, MPG, WPW, KD, SS, and CLR.Critical revision of the manuscript for important intellectual content: ADK, DRG, CN, AR, MPG, WPW, KD, SS and CLR.All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Sahar Shekoohi.

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Conflict of Interest

Christopher L. Robinson is a consultant for Augmend Health and Section Editor of Current Pain and Headache Reports. Alan D. Kaye is a section editor for Current Pain and Headache Reports.

Human and Animal Rights

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

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This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any authors.

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Kaye, A.D., Greene, D.R., Nguyen, C. et al. Emerging Medications and Strategies in Acute Pain Management: Evolving Role of Novel Sodium and Calcium Channel Blockers, Peptide-Based Pharmacologic Drugs, and Non-Medicinal Methods. Curr Pain Headache Rep (2024). https://doi.org/10.1007/s11916-024-01265-z

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