Skip to main content

Advertisement

Log in

Optimal Perioperative Pain Management of the Transgender Patient for Gender Affirming Surgery: A Scoping Review

  • New and Emerging Therapies in Interventional Pain Medicine (J Hasoon, Section Editor)
  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

Introduction

As we increasingly encounter transgender patients in the perioperative setting, it is important to be cognizant of appropriate medical management of the transgender patient. There is limited literature on the appropriate perioperative techniques to implement for adequate pain control in the transgender patient presenting for gender affirming procedures.

Methods

In this scoping review, the authors identify publications that address perioperative pain control techniques that can be implemented by the anesthesiologist such as regional anesthesia, multimodal medications, or non-pharmacologic modalities.

Results

This scoping review included two retrospective reviews, two case reports, and one letter to the editor. There are no prospective, randomized controlled trials on this topic. The limitations of this scoping review include the limited publications that are available to analyze as this is a growing area of medicine.

Conclusion

There are numerous variables that may play a factor in the pain experience of the transgender patient including biological factors, psychological and social factors. Techniques that are necessary for comprehensive pain management include pharmacologic, injections, physical therapy, acupuncture, massage, and more. There are limited publications on the comprehensive pain management of the transgender patient; therefore, the authors advocate that as perioperative physicians, anesthesiologists implement comprehensive preemptive analgesia techniques to avoid progression to chronic pain. Clearly more research is necessary to standardize acute pain management techniques in the transgender patient.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

Availability of Data and Materials

Review protocol can be requested. Template data collection forms are available upon request.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Herman J FA, O’Neill K. How many adults and youth identify as transgender in the United States? 2022. https://williamsinstitute.law.ucla.edu/publications/trans-adults-united-states/. Accessed Aug 2023.

  2. ASPS (American Society of Plastic Surgeons). Plastic surgery statistics report. 2017.

  3. Merrick E, Weissman JP, Ascha M, Jordan SW, Ellis M. National trends in gender-affirming surgical procedures: a Google Trends analysis. Cureus. 2022;14(6): e25906. https://doi.org/10.7759/cureus.25906.

    Article  PubMed  PubMed Central  Google Scholar 

  4. •• Tollinche LE, Van Rooyen C, Afonso A, Fischer GW, Yeoh CB. Considerations for transgender patients perioperatively. Anesthesiol Clin. 2020;38(2):311–26. https://doi.org/10.1016/j.anclin.2020.01.009. This is a comprehensive review of considerations for all transgender patients in the perioperative periodpresents for gender affirming surgeries as well as other elective/urgent procedures.

  5. Tollinche LE, Walters CB, Radix A, et al. The perioperative care of the transgender patient. Anesth Analg. 2018;127(2):359–66. https://doi.org/10.1213/ANE.0000000000003371.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Athnaiel O, Cantillo S, Paredes S, Knezevic NN. The role of sex hormones in pain-related conditions. Int J Mol Sci. 2023;24(3):1866. https://doi.org/10.3390/ijms24031866.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. • Sanchez KJ, Sanchez RA, Ben Khallouq B, Ellis DB. Perioperative care of transgender and gender-diverse patients: a biopsychosocial approach. Anesth Analg. 2023;137(1):234–46. https://doi.org/10.1213/ANE.0000000000006480. This is a review of approach transgender patients with empathy in the perioperative period via a biopsychosocial approach.

  8. Aquino NJ, Boskey ER, Staffa SJ, Ganor O, Crest AW, Gemmill KV, et al. A single center case series of gender-affirming surgeries and the evolution of a specialty anesthesia team. J Clin Med. 2022;11(7):1943. https://doi.org/10.3390/jcm11071943.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Salgado CJ, Gonzalez DI, Wolfe EM, Balise RR, Gebhard RE, Kamisetti S, et al. Combined general and epidural anesthesia is associated with decreased opioid consumption and enhanced pain control after penile inversion vaginoplasty in transwomen. Ann Plast Surg. 2019;83(6):681–6. https://doi.org/10.1097/SAP.0000000000001921.

    Article  CAS  PubMed  Google Scholar 

  10. Verduzco LA. Low thoracic erector spinae plane block for perioperative analgesia in transfeminine bottom surgery. Korean J Anesthesiol. 2020;73(5):460–1. https://doi.org/10.4097/kja.20023.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Bosinci ES, Stevic MM, Simic DM, Kupeli I, Spasic SM, Simic IR. A combination of bilateral pectoral nerve block and bilateral erector spinae plane block for one-stage female-to-male gender affirmation surgery: a report of two cases. J Clin Anesth. 2021;72: 110298. https://doi.org/10.1016/j.jclinane.2021.110298.

    Article  PubMed  Google Scholar 

  12. Sen S, de Haan JB, Guvernator G, et al. Lumbosacral paraspinal interfascial plane blocks for pain control after feminizing genital gender affirmation surgery. Pain Manag. 2021;11(3):277–86. https://doi.org/10.2217/pmt-2020-0062.

    Article  PubMed  Google Scholar 

  13. Sorge RE, Totsch SK. Sex differences in pain. J Neurosci Res. 2017;95(6):1271–81. https://doi.org/10.1002/jnr.23841.

    Article  CAS  PubMed  Google Scholar 

  14. • Joshi GP, Kehlet H. Postoperative pain management in the era of ERAS: an overview. Best Pract Res Clin Anaesthesiol. 2019;33(3):259–67. https://doi.org/10.1016/j.bpa.2019.07.016. This is an overview regarding best practices for post operative pain management in the setting of enhanced recovery after surgery utilizing comprehensive approaches including medications and regional anesthetics.

  15. Valentine SE, Shipherd JC. A systematic review of social stress and mental health among transgender and gender non-conforming people in the United States. Clin Psychol Rev. 2018;66:24–38. https://doi.org/10.1016/j.cpr.2018.03.003.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Kecojevic A, Wong CF, Schrager SM, Silva K, Bloom JJ, Iverson E, et al. Initiation into prescription drug misuse: differences between lesbian, gay, bisexual, transgender (LGBT) and heterosexual high-risk young adults in Los Angeles and New York. Addict Behav. 2012;37(11):1289–93. https://doi.org/10.1016/j.addbeh.2012.06.006.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Robinson KA, Duncan S, Austrie J, Fleishman A, Tobias A, Hopwood RA, et al. Opioid consumption after gender-affirming mastectomy and two other breast surgeries. J Surg Res. 2020;251:33–7. https://doi.org/10.1016/j.jss.2019.12.043.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

AP and PS conceived the idea, filtered the articles, and contributed to the manuscript writing. VP identified the pertinent articles and contributed to the manuscript writing.

Corresponding author

Correspondence to Alopi Patel.

Ethics declarations

Conflict of Interest

There are no competing interests for the review authors.

Human and Animal Rights and Informed Consent

This scoping review was not registered as it was not required under PROSPERO. This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Appendix

Appendix

In PubMed

(“Transgender Persons”[Mesh] OR “Intersex Persons”[Mesh] OR Transgender OR Transsexual OR Transfeminine OR Transmasculine OR Intersex) AND (“Sex Reassignment Surgery”[Mesh] OR “Gender affirm*” OR “Gender confirm*” OR “Sex reassignment” OR “Gender reassignment” OR “Gender change” OR “Sex change” OR Feminiz* OR Masculin*) AND (“Surgical Procedures, Operative”[Mesh] OR Surger*) AND (“Pain”[Mesh] OR pain).

In Scopus

(“Transgender Persons” OR “Intersex Persons” OR Transgender OR Transsexual OR Transfeminine OR Transmasculine OR Intersex) AND (“Sex Reassignment Surgery” OR “Gender affirm*” OR “Gender confirm*” OR “Sex reassignment” OR “Gender reassignment” OR “Gender change” OR “Sex change” OR Feminiz* OR Masculin*) AND (“Surgical Procedures, Operative” OR Surger*) AND (“Pain” OR pain).

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Patel, A., Palayeker, V. & Shekane, P. Optimal Perioperative Pain Management of the Transgender Patient for Gender Affirming Surgery: A Scoping Review. Curr Pain Headache Rep (2024). https://doi.org/10.1007/s11916-024-01219-5

Download citation

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s11916-024-01219-5

Keywords

Navigation