Abstract
Purpose of Review
In this review article, we summarize the most recent findings and observations in patients experiencing primary cough headache.
Recent Findings
Recent studies draw attention to further characterization of patients with primary cough headache in a pulmonology clinic. There have also been recent case studies describing new therapy considerations, including noninvasive vagus nerve stimulation and lumbar punctures.
Summary
Primary cough headache has been a recognized entity since as early as 1932. Patients generally report a sudden onset, sharp headache lasting a few hours that is precipitated by Valsalva maneuver or coughing. It remains an uncommon diagnosis, and secondary causes are crucial to rule out with imaging studies. Additionally, there can be an overlap with other primary headache disorders such as primary exercise headache and headache associated with sexual activity, thus requiring a detailed history. Many hypotheses exist regarding the pathophysiology including relative pressure gradients and a crowded posterior fossa. Generally, patients are responsive to indomethacin, but more recent case reports have suggested benefits of other medications and procedures that may offer patients an alternative option, including vagus nerve stimulation, lumbar punctures, and beta blockers. Future case series and studies should focus on management of these patients, with a specific focus on individuals who do not tolerate indomethacin.
Similar content being viewed by others
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Tinel J. La céphalée a l’effort. Syndrome de distension douloureuse des veines intracraniennes. Medicine (Paris). 1932;13:113–8.
Symonds C. Cough headache. Brain. 1956;79(4):557–68.
Souza WP, Sousa‐Santos PM, Silva‐Néto RP. A historical review of headaches: who first described them and when did this occur? Headache. 2020;60(8):1535–41.
Rooke ED. Benign exertional headache. Med Clin North Am. 1968;52(4):801–8.
Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018; 38(1): 1- 211:
Pascual J, Combarros O, Leno C, Polo JM, Rebollo Alvarez-Armandi M, Berciano J. Distribución por diagnósticos del dolor de cabeza como motivo de consulta neurológica. Med Clin. 1995;104(5):161–4.
Rasmussen BK, Olesen J. Symptomatic and nonsymptomatic headaches in a general population. Neurology. 1992;42(6):1225.
Chen PK, Fuh JL, Wang SJ. Cough headache: a study of 83 consecutive patients. Cephalalgia. 2009;29(10):1079–85.
Pascual J, Iglesias F, Oterino A, Vazquez-Barquero A, Berciano J. Cough, exertional, and sexual headaches: an analysis of 72 benign and symptomatic cases. Neurology. 1996;46(6):1520–4.
Alvarez R, Ramón C, Pascual J. Clues in the differential diagnosis of primary vs secondary cough, exercise, and sexual headaches. Headache: J Head Face Pain. 2014;54(9):1560–2.
Villar‐Martínez MD, Moreno‐Ajona D, Chan C, Goadsby PJ. Indomethacin‐responsive headaches—a narrative review. Headache: J Head Face Pain. 2021;61(5):700–14.
•• Zhang Y, Zhao X, Wang Y, Dong Z, Yu S. Prevalence and characteristics of cough headache in a Chinese respiratory clinic. Cephalalgia. 2021;41(3):366–74. A clinical study evaluating the demographics and clinical features of patients with primary cough headache in a respiratory clinic.
Raskin NH. The cough headache syndrome: treatment. Neurology. 1995;45(9):1784-.
Donnet A, Valade D, Houdart E, Lanteri-Minet M, Raffaelli C, Demarquay G, et al. Primary cough headache, primary exertional headache, and primary headache associated with sexual activity: a clinical and radiological study. Neuroradiology. 2013;55:297–305.
Pascual J. Primary cough headache. Curr Pain Headache Rep. 2005;9(4):272–6.
Chen YY, Lirng JF, Fuh JL, Chang FC, Cheng HC, Wang SJ. Primary cough headache is associated with posterior fossa crowdedness: a morphometric MRI study. Cephalalgia. 2004;24(9):694–9.
Wang SJ, Fuh JL, Lu SR. Benign cough headache is responsive to acetazolamide. Neurology. 2000;55(1):149–50.
Wolff HG. Pain-sensitive structures within the cranial cavity. Headache and other pain, 2nd edn. Oxford university Press, New York. 1963:53–95.
Rissardo JP, Caprara AL. Cough, cough-induced, and primary cough headache. Matrix Science Medica. 2022;6(4):117–8.
Bahra A. Other primary headaches—thunderclap-, cough-, exertional-, and sexual headache. J Neurol. 2020;267(5):1554–66.
Pavão Martins I, Viana P. “Cough hemicrania”–an overlapping form of headache. Headache. 2017;57(5):796–800.
Thunstedt DC, Schmutzer M, Fabritius MP, Thorsteinsdottir J, Kunz M, Ruscheweyh R, et al. Headache characteristics and postoperative course in Chiari I malformation. Cephalalgia. 2022;42(9):879–87.
Skau M, et al. What is new about idiopathic intracranial hypertension? An updated review of mechanism and treatment. Cephalalgia. 2006;26(4):384–99.
Evans RW, Boes CJ. Spontaneous low cerebrospinal fluid pressure syndrome can mimic primary cough headache. Headache. 2005;45(4):374–7.
Heijkoop TY, Hammer S, Koppen H. Cough headache in a patient with an intradiploic leptomeningeal cyst: a case report. Headache. 2019;59(4):590–2.
Cordenier A, De Hertogh W, De Keyser J, Versijpt J. Headache associated with cough: a review. J Headache Pain. 2013;14(1):1–7.
Haddad T, Wang V, Parikh S. Cerebral venous sinus pressure and head pain: a case of cough headache secondary to superior sagittal sinus stenosis (P3–12.009).
Maramattom BV. Cough headache as a presenting feature of posterior reversible encephalopathy syndrome (PRES). Clin Med. 2021;21(2):e237.
Sandoe CH, Kingston W. Exercise headache: a review. Curr Neurol Neurosci Rep. 2018;18:1–6.
Mathew NT. Indomethacin responsive headache syndromes. Headache. 1981;21(4):147–50.
Diamond S, Medina JL. Benign exertional headache-successful treatment with indomethacin. InHeadache 1979 (Vol. 19, No. 4, pp. 249–249). 875 Kings Highway, Ste 200, Woodbury, NJ 08096: Amer Assoc Study Headache.
•• Moreno-Ajona D, Villar-Martínez MD, Goadsby PJ, Hoffmann J. Primary cough headache treated with non-invasive vagal nerve stimulation. Neurology. 2020;95(13):593–4. Case study describing the use of non-invasive vagus nerve stimulation for the treatment of primary cough headache.
Villar-Martinez MD, Goadsby PJ. Non-invasive neuromodulation of the cervical vagus nerve in rare primary headaches. Front Pain Res. 2023;4.
• Kesserwani H, Kesserwani HN. Primary cough headache disorder responds to low volume therapeutic lumbar puncture: a case report with a side note on therapeutics and cranio-spinal dissociation. Cureus. 2020;12(9). Case study describing the use of low volume lumbar puncture for the treatment of primary cough headache.
Upadhyaya P, Nandyala A, Ailani J. Primary exercise headache. Curr Neurol Neurosci Rep. 2020;20:1–4.
Medrano V, Mallada J, Sempere AP, Fernandez S, Piqueras L. Primary cough headache responsive to topiramate. Cephalalgia. 2005;25(8):627.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
Arathi Nandyala has no financial or non-financial interests to disclose that are directly or indirectly related to the work submitted for publication. Niushen Zhang has no financial or non-financial interests to disclose that are directly or indirectly related to the work submitted for publication.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Nandyala, A., Zhang, N. Primary Cough Headache. Curr Pain Headache Rep 27, 679–684 (2023). https://doi.org/10.1007/s11916-023-01171-w
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11916-023-01171-w