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Interplay of Oral, Mandibular, and Facial Disorders and Migraine

  • Episodic Migraine (S Nahas, Section Editor)
  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

Purpose of the Review

Migraine and other primary headache disorders can be localized in the face resembling facial or dental pain, indicating the influence of the trigeminovascular system in the structures innervated by the maxillary (V2) and mandibulary (V3) branches of the trigeminal nerve. Disorders of oral and craniofacial structures may influence primary headache disorders. In the current article, we review the potential links of this interplay.

Recent Findings

This interplay may be related to anatomy, with the trigeminal pathway and the involvement of both peripheral and central mechanisms, and the presence of calcitonin gene–related peptide (CGRP), a key mediator in migraine pathophysiology. CGRP is also involved in the pathophysiology of temporomandibular disorders (TMD) and their comorbidity with migraine and is also implicated in dental and periodontal pathology.

Summary

Inflammatory and pathological processes of these structures and their trigeminal nociceptive pathways may influence the trigeminovascular system and consequently may exacerbate or even potentially trigger migraine.

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Acknowledgements

We would like to thank Dr. Simon Akerman, Department of Neural and Pain Sciences, University of Maryland, Baltimore, School of Dentistry, for reviewing the manuscript and assistance with the figure.

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Authors and Affiliations

  1. Head Pain Institute, 9481 E Ironwood Square Dr. Scottsdale, Scottsdale, AZ, 85258, USA

    Antonia Teruel

  2. Brotman Facial Pain Clinic, Department of Neural and Pain Sciences, University of Maryland, School of Dentistry, 650 W. Baltimore St. 8th Floor, Baltimore, MD, 21201, USA

    Marcela Romero-Reyes

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  1. Antonia Teruel
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  2. Marcela Romero-Reyes
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Correspondence to Marcela Romero-Reyes.

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Teruel, A., Romero-Reyes, M. Interplay of Oral, Mandibular, and Facial Disorders and Migraine. Curr Pain Headache Rep 26, 517–523 (2022). https://doi.org/10.1007/s11916-022-01054-6

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