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Flavonoids in the Treatment of Neuropathic Pain


Purpose of Review

Chronic pain continues to present a large burden to the US healthcare system. Neuropathic pain, a common class of chronic pain, remains particularly difficult to treat despite extensive research efforts. Current pharmacologic regimens exert limited efficacy and wide, potentially dangerous side effect profiles. This review provides a comprehensive, preclinical evaluation of the literature regarding the role of flavonoids in the treatment of neuropathic pain.

Recent Findings

Flavonoids are naturally occurring compounds, found in plants and various dietary sources, which may have potential benefit in neuropathic pain. Numerous animal-model studies have demonstrated this benefit, including reversal of hyperalgesia and allodynia. Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-α, NF-κB, IL-1β, and IL-6.


Flavonoids represent a potentially new treatment modality for neuropathic pain in preclinical models, though human clinical evidence is yet to be explored at this time.

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Papers of particular interest, published recently, have been highlighted as: • Of importance

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Correspondence to Mark Jones.

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Conflict of Interest

Richard D. Urman reports funding or fees from Medtronic, Merck, Acacia, Takeda, Pfizer, and AcelRx. Amitabh Gulati is a consultant for Medtronic, Flowonix, SPR Therapeutics, Nalu Medical, Bausch Health, and advisor for AIS. The other authors declare that no competing interests exist.

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This article is part of the Topical Collection on Alternative Treatments for Pain Medicine

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Rao, P.N., Mainkar, O., Bansal, N. et al. Flavonoids in the Treatment of Neuropathic Pain. Curr Pain Headache Rep 25, 43 (2021).

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  • Neuropathic pain
  • Flavonoids
  • Neuroinflammation
  • Chronic pain
  • Treatment