Emerging Novel Pharmacological Non-opioid Therapies in Headache Management: a Comprehensive Review

  • Alan David Kaye
  • Mark W. Motejunas
  • Elyse M. CornettEmail author
  • Ken P. Ehrhardt
  • Matthew B. Novitch
  • Joshua Class
  • Harish Siddaiah
  • Brendon M. Hart
  • Richard D. Urman
Other Pain (A Kaye and N Vadivelu, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Other Pain


Purpose of Review

Chronic headache is a significant worldwide problem despite advances in treatment options. Chronic headaches can have significant a detrimental impact on the activities of daily living.

Recent Findings

Patients who do not obtain relief from chronic head and neck pain from conservative treatments are commonly being managed with interventional treatments. These interventional treatment options include botulinum toxin A, injections, local occipital nerve anesthetic and corticosteroid infiltration, occipital nerve subcutaneous stimulation and occipital nerve pulsed radiofrequency (PRF), sphenopalatine ganglion block, and radiofrequency techniques.


Recently, evidence has emerged to support non-opioid-based drug and interventional approaches. Overall, more research is necessary to clarify the safety and efficacy of interventional treatments and to better understand the pathogenesis of chronic headache pain.


Non-opioid Headache Botox Multimodal analgesia 


Compliance with Ethical Standards

Conflict of Interest

All authors declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Alan David Kaye
    • 1
  • Mark W. Motejunas
    • 1
  • Elyse M. Cornett
    • 2
    Email author
  • Ken P. Ehrhardt
    • 1
  • Matthew B. Novitch
    • 3
  • Joshua Class
    • 4
  • Harish Siddaiah
    • 2
  • Brendon M. Hart
    • 2
  • Richard D. Urman
    • 4
  1. 1.Department of AnesthesiologyLSU Health Sciences CenterNew OrleansUSA
  2. 2.Department of AnesthesiologyLSU Health ShreveportShreveportUSA
  3. 3.University of Washington AnesthesiologySeattleUSA
  4. 4.Department of Anesthesiology, Perioperative and Pain MedicineHarvard Medical School, Brigham and Women’s HospitalBostonUSA

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