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History of NSAID Use in the Treatment of Headaches Pre and Post-industrial Revolution in the United States: the Rise and Fall of Antipyrine, Salicylic Acid, and Acetanilide

Abstract

Purpose of Review

Non-steroid anti-inflammatory drugs (NSAIDs) constitute a vital class of medications in today’s headache regimen. However, up until the nineteenth century, they were largely unknown to most of the medical community. The purpose of this review is to explore the evolution of NSAIDs in the treatment of headaches spurred on by the Industrial Revolution in the USA.

Recent Findings

The currently available data on the impact of NSAIDs reflects their significant contribution to headache treatment.

Summary

The emergence of mass production spurred on by the Industrial Revolution, lead to widespread use of antipyrine, salicylic acid, and acetanilide. However, along with it came the growing awareness of consumer safety, leading to their ultimate downfall, and the subsequent birth of the Food and Drug Act.

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Correspondence to Sidrah Mahmud.

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Mahmud, S., Rosen, N. History of NSAID Use in the Treatment of Headaches Pre and Post-industrial Revolution in the United States: the Rise and Fall of Antipyrine, Salicylic Acid, and Acetanilide. Curr Pain Headache Rep 23, 6 (2019). https://doi.org/10.1007/s11916-019-0744-6

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Keywords

  • Headache
  • NSAID
  • History
  • Antipyrine
  • Salicylic acid
  • Acetanilide
  • Post-Industrial Revolution