Abstract
Purpose of Review
The clinical diagnostic dilemma of low back pain that is associated with lower limb pain is very common. In relation to back pain that radiates to the leg, the International Association for the Study of Pain (IASP) states: “Pain in the lower limb should be described specifically as either referred pain or radicular pain. In cases of doubt no implication should be made and the pain should be described as pain in the lower limb.”
Recent Findings
Bogduks’ editorial in the journal PAIN (2009) helps us to differentiate and define the terms somatic referred pain, radicular pain, and radiculopathy. In addition, there are other pathologies distal to the nerve root that could be relevant to patients with back pain and leg pain such as plexus and peripheral nerve involvement. Hence, the diagnosis of back pain with leg pain can still be challenging.
Summary
In this article, we present a patient with back and leg pain. The patient appears to have a radicular pain syndrome, but has no neurological impairment and shows signs of myofascial involvement. Is there a single diagnosis or indeed two overlapping syndromes? The scope of our article encompasses the common diagnostic possibilities for this type of patient. A discussion of treatment is beyond the scope of this article and depends on the final diagnosis/diagnoses made.
Similar content being viewed by others
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Merskey HE. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms. Pain. 1986.
•• Bogduk N. On the definitions and physiology of back pain, referred pain, and radicular pain. Pain. 2009;147(1–2–3):17–9. This is a very important editorial defining the different mechanisms of back and leg pain
Kellgren J. Sciatica. Lancet. 1941;237(6140):561–4.
Simons DG, Travell JG, Simons LS, Travell JG. Travell & Simons’ myofascial pain and dysfunction: the trigger point manual. 2nd ed. Baltimore: Williams & Wilkins; 1999. v. <1 >
Simons DG, Travell JG, Simons LS. Travell & Simons’ myofascial pain and dysfunction: the trigger point manual. 2. The lower extremities. Williams & Wilkins; 1999.
Gellhorn AC, Katz JN, Suri P. Osteoarthritis of the spine: the facet joints. Nat Rev Rheumatol. 2013;9(4):216–24.
Schellinger D, Wener L, Ragsdale BD, Patronas NJ. Facet joint disorders and their role in the production of back pain and sciatica. Radiographics. 1987;7(5):923–44.
Freiberg AH, Vinke TH. Sciatica and the sacro-iliac joint. J Bone Jt Surg Am. 1934;16(1):126–36.
Slipman CW, Jackson HB, Lipetz JS, Chan KT, Lenrow D, Vresilovic EJ. Sacroiliac joint pain referral zones. Arch Phys Med Rehabil. 2000;81(3):334–8.
O’Neill CW, Kurgansky ME, Derby R, Ryan DP. Disc stimulation and patterns of referred pain. Spine. 2002;27(24):2776–81.
• Kellgren JH. On the distribution of pain arising from deep somatic structures with charts of segmental pain areas. Clin Sci. 1939;4:35–46. Although a very old study, an extremely important clinical study of the referral of pain from somatic structures
Feinstein B, Langton JN, Jameson R, Schiller F. Experiments on pain referred from deep somatic tissues. J Bone Jt Surg. 1954;36(5):981–97.
Steindler A. The interpretation of sciatic radiation and the syndrome of low-back pain. J Bone Jt Surg Am. 1940;22(1):28–34.
Desai MJ, Saini V, Saini S. Myofascial pain syndrome: a treatment review. Pain Ther. 2013;2(1):21–36.
Benoist M. The natural history of lumbar disc herniation and radiculopathy. Joint Bone Spine. 2002;69(2):155–60.
Deyo RA, Rainville J, Kent DL. What can the history and physical examination tell us about low back pain? JAMA. 1992;268(6):760–5.
Ropper AH, Zafonte RD. Sciatica. N Engl J Med. 2015;2015(372):1240–8.
Bickels J, Kahanovitz N, Rubert CK, Henshaw RM, Moss DP, Meller I, et al. Extraspinal bone and soft-tissue tumors as a cause of sciatica: clinical diagnosis and recommendations: analysis of 32 cases. Spine. 1999;24(15):1611.
Kulcu DG, Naderi S. Differential diagnosis of intraspinal and extraspinal non-discogenic sciatica. J Clin Neurosci. 2008;15(11):1246–52.
Hakelius A. Prognosis in sciatica: a clinical follow-up of surgical and non-surgical treatment. Acta Orthop Scand. 1970;41(sup 129):1–76.
Weber H. Lumbar disc herniation: a controlled, prospective study with ten years of observation. Spine. 1983;8(2):131–40.
SAAL JA, SAAL JS. Nonoperative treatment of herniated lumbar intervertebral disc with radiculopathy: an outcome study. Spine. 1989;14(4):431–7.
Bush K, Cowan N, Katz DE, Gishen P. The natural history of sciatica associated with disc pathology: a prospective study with clinical and independent radiologic follow-up. Spine. 1992;17(10):1205–12.
Fernandez M, Ferreira ML, Refshauge KM, Hartvigsen J, Silva IR, Maher CG, et al. Surgery or physical activity in the management of sciatica: a systematic review and meta-analysis. Eur Spine J. 2015:1–18.
Maigne J-Y, Rime B, Deligne B. Computed tomographic follow-up study of forty-eight cases of nonoperatively treated lumbar intervertebral disc herniation. Spine. 1992;17(9):1071–4.
Delauche-Cavallier M-C, Budet C, Laredo J-D, Debie B, Wybier M, Dorfmann H, et al. Lumbar disc herniation: computed tomography scan changes after conservative treatment of nerve root compression. Spine. 1992;17(8):927–33.
Bozzao A, Gallucci M, Masciocchi C, Aprile I, Barile A, Passariello R. Lumbar disk herniation: MR imaging assessment of natural history in patients treated without surgery. Radiology. 1992;185(1):135–41.
Dullerud R, Nakstad P. CT changes after conservative treatment for lumbar disk herniation. Acta Radiol. 1994;35(5):415–9.
Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS. Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med. 1994;331(2):69–73.
Boden SD, Davis D, Dina T, Patronas N, Wiesel S. Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bone Jt Surg Am. 1990;72(3):403–8.
Borenstein DG, O’Mara JW, Boden SD, Lauerman WC, Jacobson A, Platenberg C, et al. The value of magnetic resonance imaging of the lumbar spine to predict low-back pain in asymptomatic subjects. J Bone Jt Surg Am. 2001;83(9):1306–11.
Kelly M. Is pain due to pressure on nerves? Spinal tumors and the intervertebral disk. Neurology. 1956;6(1):32.
Smyth M, Wright V. Sciatica and the intervertebral disc. J Bone Jt Surg Am. 1958;40(6):1401–18.
Stafford M, Peng P, Hill D. Sciatica: a review of history, epidemiology, pathogenesis, and the role of epidural steroid injection in management. Br J Anaesth. 2007;99(4):461–73.
Lindahl O. Hyperalgesia of the lumbar nerve roots in sciatica. Acta Orthop Scand. 1966;37(4):367–74.
Lindahl O, Rexed B. Histologic changes in spinal nerve roots of operated cases of sciatica. Acta Orthop Scand. 1951;20(3):215–25.
Goupille P, Jayson MI, Valat J-P, Freemont AJ. The role of inflammation in disk herniation-associated radiculopathy. In Elsevier; 1998. p. 60–71.
Burke J, Watson R, McCormack D, Dowling F, Walsh M, Fitzpatrick J. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. Bone Jt J. 2002;84(2):196–201.
Mulleman D, Mammou S, Griffoul I, Watier H, Goupille P. Pathophysiology of disk-related sciatica. I.—evidence supporting a chemical component. Joint Bone Spine. 2006;73(2):151–8.
Nygaard ØP, Mellgren SI, Østerud B. The inflammatory properties of contained and noncontained lumbar disc herniation. Spine. 1997;22(21):2484–8.
Peng B, Wu W, Hou S, Li P, Zhang C, Yang Y. The pathogenesis of discogenic low back pain. Bone Jt J. 2005;87(1):62–7.
Shamji MF, Setton LA, Jarvis W, So S, Chen J, Jing L, et al. Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. Arthritis Rheum. 2010;62(7):1974–82.
Brisby H, Olmarker K, Larsson K, Nutu M, Rydevik B. Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica. Eur Spine J. 2002;11(1):62–6.
Zu B, Pan H, Zhang X-J, Yin Z-S. Serum levels of the inflammatory cytokines in patients with lumbar radicular pain due to disc herniation. Asian Spine J. 2016;10(5):843–9.
Pedersen LM, Schistad E, Jacobsen LM, Røe C, Gjerstad J. Serum levels of the pro-inflammatory interleukins 6 (IL-6) and-8 (IL-8) in patients with lumbar radicular pain due to disc herniation: a 12-month prospective study. Brain Behav Immun. 2015;46:132–6.
Brisby H, Olmarker K, Rosengren L, Cederlund C, Rydevik B. Markers of nerve tissue injury in the cerebrospinal fluid in patients with lumbar disc herniation and sciatica. Spine. 1999;24(8):742–6.
Galluzzi KE. Management of neuropathic pain. J Am Osteopath Assoc. 2005;105(suppl_4):S12–9.
Chokroverty S, Reyes M, Rubino F, Tonaki H. The syndrome of diabetic amyotrophy. Ann Neurol. 1977;2(3):181–94.
Pradat P, Delanian S. Late radiation injury to peripheral nerves. Handb Clin Neurol. 2012;115:743–58.
Lundborg G, Dahlin LB. Anatomy, function, and pathophysiology of peripheral nerves and nerve compression. Hand Clin. 1996;12(2):185–93.
Flanigan RM, DiGiovanni BF. Peripheral nerve entrapments of the lower leg, ankle, and foot. Foot Ankle Clin. 2011;16(2):255–74.
Yeoman W. The relation of arthritis of the sacro-iliac joint to sciatica, with an analysis of 100 cases. Lancet. 1928;212(5492):1119–23.
Robinson DR. Pyriformis syndrome in relation to sciatic pain. Am J Surg. 1947;73(3):355–8.
Tiel RL. Piriformis and related entrapment syndromes: myth & fallacy. Neurosurg Clin N Am. 2008;19(4):623–7.
Michel F, Decavel P, Toussirot E, Tatu L, Aleton E, Monnier G, et al. The piriformis muscle syndrome: an exploration of anatomical context, pathophysiological hypotheses and diagnostic criteria. Ann Phys Rehabil Med. 2013;56(4):300–11.
Issack PS, Toro JB, Buly RL, Helfet DL. Sciatic nerve release following fracture or reconstructive surgery of the acetabulum. J Bone Jt Surg Am. 2007;89(7):1432–7.
Hopayian K, Song F, Riera R, Sambandan S. The clinical features of the piriformis syndrome: a systematic review. Eur Spine J. 2010;19(12):2095–109.
Lewis AM, Layzer R, Engstrom J, Barbaro NM, Chin CT. Magnetic resonance neurography in extraspinal sciatica. Arch Neurol. 2006;63(10):1469–72.
Pecina HI, Boric I, Smoljanovic T, Duvancic D, Pecina M. Surgical evaluation of magnetic resonance imaging findings in piriformis muscle syndrome. Skelet Radiol. 2008;37(11):1019–23.
Fishman LM, Zybert PA. Electrophysiologic evidence of piriformis syndrome. Arch Phys Med Rehabil. 1992;73(4):359–64.
Fishman LM, Dombi GW, Michaelsen C, Ringel S, Rozbruch J, Rosner B, et al. Piriformis syndrome: diagnosis, treatment, and outcome—a 10-year study. Arch Phys Med Rehabil. 2002;83(3):295–301.
Martin HD, Palmer IJ. History and physical examination of the hip: the basics. Curr Rev Musculoskelet Med. 2013;6(3):219–25.
Jankovic D, Peng P, van Zundert A. Brief review: piriformis syndrome: etiology, diagnosis, and management. Can J Anesth Can Anesth. 2013;60(10):1003–12.
Benson ER, Schutzer SF. Posttraumatic piriformis syndrome: diagnosis and results of operative treatment. J Bone Jt Surg. 1999;81(7):941–9.
Park M, Yoon S-J, Jung S, Kim S-H. Clinical results of endoscopic sciatic nerve decompression for deep gluteal syndrome: mean 2-year follow-up. BMC Musculoskelet Disord. 2016;17(1):1.
Poage C, Roth C, Scott B. Peroneal nerve palsy: evaluation and management. J Am Acad Orthop Surg. 2016;24(1):1–10.
Baxter D. Functional nerve disorders in the athlete’s foot, ankle, and leg. Instr Course Lect. 1992;42:185–94.
Devillé WL, van der Windt DA, Dzaferagic A, Bezemer P, Bouter LM. The test of Lasegue: systematic review of the accuracy in diagnosing herniated discs. Spine. 2000;25(9):1140–7.
Kellgren J. Observations on referred pain arising from muscle. Clin Sci. 1938;3(176):1937–8.
Good M. Diagnosis and treatment of sciatic pain. J Nerv Ment Dis. 1944;100(4):433.
Inman Verne SJ. Referred pain from skeletal structures. J Nerv Ment Dis. 1944;99(5):8.
King J, Lagger R. Sciatica viewed as a referred pain syndrome. Surg Neurol. 1976;5(1):46–50.
Meyer GA, Haughton VM, Williams AL. Diagnosis of herniated lumbar disk with computed tomography. N Engl J Med. 1979;301(21):1166–7.
Frymoyer JW. Back pain and sciatica. N Engl J Med. 1988;318(5):291–300.
Deyo RA, Mirza SK. Herniated lumbar intervertebral disk. N Engl J Med. 2016;374(18):1763–72.
Chou R, Qaseem A, Owens DK, Shekelle P. Diagnostic imaging for low back pain: advice for high-value health care from the American College of Physicians. Ann Intern Med. 2011;154(3):181–9.
• Adelmanesh F, Jalali A, Shooshtari SMJ, Raissi GR, Ketabchi SM, Shir Y. Is there an association between lumbosacral radiculopathy and painful gluteal trigger points?: a cross-sectional study. Am J Phys Med Rehabil. 2015;94(10):784–91. A recent study presenting the coexistence of lumbosacral radiculopathy and myofascial trigger points
Fang G, Zhou J, Liu Y, Sang H, Xu X, Ding Z. Which level is responsible for gluteal pain in lumbar disc hernia? BMC Musculoskelet Disord. 2016;17(1):356.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
Simon Vulfsons, Negev Bar, and Elon Eisenberg declare that they have no conflicts of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
This article is part of the Topical Collection on Neuropathic Pain
Rights and permissions
About this article
Cite this article
Vulfsons, S., Bar, N. & Eisenberg, E. Back Pain with Leg Pain. Curr Pain Headache Rep 21, 32 (2017). https://doi.org/10.1007/s11916-017-0632-x
Published:
DOI: https://doi.org/10.1007/s11916-017-0632-x