Skip to main content

Advertisement

Log in

Opioid Treatment of Migraine: Risk Factors and Behavioral Issues

  • Psychological and Behavioral Aspects of Headache and Pain (D Buse, Section Editor)
  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

Migraine can impact every aspect of a person’s functioning. Psychological comorbidities, cognitive constructs, and behavioral responses to pain greatly impact the perception of migraine pain, treatment efficacy and outcome, and overall quality of life and functioning. Current considerations for migraine treatment emphasize the utility of the biopsychosocial model in understanding and treating migraine, noting both the importance of addressing psychological factors such as cognitive beliefs as well as psychiatric comorbidities. The guidelines for migraine treatment implicate opioid therapy as a second or third tier treatment. Guidelines and recommendations for the safe use of opioid medications among patients with chronic pain emphasize the importance of screening prior to prescribing opioid medications. Chronic opioid therapy has been shown to further levels of disability, decrease quality of life, and correlate to psychiatric comorbidities, concerns that are already present in migraine patients. While opioid treatment provides an alternative for persons with contraindications for alternative migraine treatments, it is critical that opioids be used sparingly and exclusively in conjunction with comprehensive assessment and integration of psychological treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. World Health Organization. World Health Report 2002. Reducing risks, promoting healthy life. Geneva: WHO; 2002.

    Google Scholar 

  2. Bigal ME, Rapoport AM, Lipton RB, Tepper SJ, Sheftell FD. Assessment of migraine disability using the Migraine Disability Assessment (MIDAS) questionnaire. A comparison of chronic migraine with episodic migraine. Headache. 2003;3:336–42.

    Article  Google Scholar 

  3. Lipton RB, Bigal ME. Ten lessons on the epidemiology of migraine. Headache. 2007;47:S2–9.

    Article  PubMed  Google Scholar 

  4. Stovner LJ, Hagen K, Jensen R, Katsarava Z, Lipton RB, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalgia. 2007;27:193–210.

    Article  Google Scholar 

  5. Stang PE, Osterhaus JT. Impact of migraine in the United States: data from the National Health Interview Survey. Headache. 1993;33:29–35.

    Article  CAS  Google Scholar 

  6. Leonardi M, Steiner TJ, Scher AT, Lipton RB. The global burden of migraine: measuring disability in headache disorders with WHO’s classification of functioning, Disability and Health (ICF). J Headache Pain. 2005;6:429–40.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache. 2001;41:646–57.

    Article  CAS  PubMed  Google Scholar 

  8. Stewart WF, Ricci JA, Leotta C, Chee E, Moranstein D, Lipton R. Lost productive time and cost due to common pain conditions in the US workforce. JAMA. 2003;290:243–2454.

    Article  Google Scholar 

  9. Stewart WF, Wood GC, Manack A, Varon SF, Buse DC, Lipton RB. Employment and work impact of chronic migraine and episodic migraine. J Occup Environ Med. 2010;52:8–14.

    Article  PubMed  Google Scholar 

  10. World Health Organization. The World Health Report 2001. Mental Health: New Understanding, New Hope. Geneva: World Health Organization; 2001. Available at: http://www.who.int/whr/2001/en/ (accessed December 2015).

    Google Scholar 

  11. Nicholson RA, Houle TT, Rudy JL, Norton PJ. Psychological risk factors in headache. Headache. 2007;47:413–26.

    PubMed  PubMed Central  Google Scholar 

  12. Jette N, Patten S, Williams J, Becker W, Wiebe S. Comorbidity of migraine and psychiatric disorders—a national population-based study. Headache. 2008;48:501–16. This article identifies the correlation between various psychiatric disorders and migraine is a very large, national population-based study. Authors conclude that migraine is associated with several mental health disorders, and results show migraine in association with mental health disorders results in poorer health related outcomes compared with migraine or psychiatric condition alone.

  13. Lipton RB, Liberman JN, Kolodner KB, Bigan ME, Dowson A, Stewart WF. Migraine headache disability and health-related quality of life: a population-based case control study from England. Cephalgia. 2003;23:441–50.

    Article  CAS  Google Scholar 

  14. Lipton RB, Hamelsky SW, Kolodner KB, Steiner TJ, Stewart WF. Migraine, quality of life, and depression: a population-based case-control study. Neurology. 2000;55:629–35.

    Article  CAS  PubMed  Google Scholar 

  15. Sullivan MJ, Adams H, Tripp D, Stanish WD. Stage of chronicity and treatment response in patients with musculoskeletal injuries and concurrent symptoms of depression. Pain. 2008;135:151–9.

    Article  PubMed  Google Scholar 

  16. Crombez G, Eccleston C, Van Damme S, Vlaeyen JWS, Karoly P. Fear-avoidance model of chronic pain: the next generation. Clin J Pain. 2012;28:475–83.

    Article  PubMed  Google Scholar 

  17. Rainville J, Smeets RJ, Bendix T, Tveito TH, Poiraudeau S, Ihdahl AJ. Fear-avoidance beliefs and pain avoidance in low back pain—translating research into clinical practice. Spine J. 2011;11(9):895–903.

    Article  PubMed  Google Scholar 

  18. Casey CY, Greenbery M, Nicassio P, Harpin RE, Hubbard D. A risk factor conceptualization of pain beliefs: response to McDonald. Pain. 2008;137(2):461–2.

    Article  Google Scholar 

  19. Kaiser RS, Mooreville M, Kannan K. Psychological interventions for the management of chronic pain: a review of current evidence. Curr Pain Headache Rep. 2015;19:43. This review concisely describes psychological factors common to chronic pain and the importance of developing a multi-modal approach to treatment.

  20. Waugh OC, Byrne DG, Nicholas MK. Internalized stigma in people living with chronic pain. J Pain. 2014;15:1–10.

    Article  Google Scholar 

  21. McCrea SK, Kaiser RS, Young WB. The relationship between personality factors and perceptions of stigma in chronic and episodic migraine patients. Los Angeles: Poster session presented at the annual scientific meeting of the American Headache Society; 2014.

    Google Scholar 

  22. McCracken LM, Vowles KE, Eccleston C. Acceptance of chronic pain: component analysis and a revised assessment method. Pain. 2004;107:159–66.

    Article  PubMed  Google Scholar 

  23. Marlowe N. Self efficacy moderates the impact of stressful events on headache. Headache. 1998;38:662–7.

    Article  CAS  PubMed  Google Scholar 

  24. French DJ, Holroyd KA, Pinell C, Malinoski PT, O’donell F, Hill KR. Perceived self efficacy and headache related disability. Headache. 2000;40:647–56.

    Article  CAS  PubMed  Google Scholar 

  25. Lauwerier E, Paemeleire K, Van Damme S, Goubert L, Crombez G. Medication use in patients with migraine and medication-overuse headache: the role of problem-solving and attitudes about pain management. Pain. 2011;152:1334–9.

    Article  PubMed  Google Scholar 

  26. Dodick DW, Silberstein SD. How clinicians can detect, prevent and treat medication overuse headache. Cephalalgia. 2008;28:1207–17.

    Article  CAS  PubMed  Google Scholar 

  27. Levin M. Opioids in headache. Headache. 2014;54:12–21.

    Article  PubMed  Google Scholar 

  28. Silberstein SD. Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Sub-committee of the American Academy of Neurology. Neurology. 2000;55:754–62.

    Article  CAS  PubMed  Google Scholar 

  29. Buse DC, Manack A, Serrano D, Turkel C, Lipton RB. Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. J Neurol Neurosurg Psychiatry. 2010;81:428–32.

    Article  CAS  PubMed  Google Scholar 

  30. Bigal ME, Lipton RB. Excessive opioid use and the development of chronic migraine. Pain. 2009;142:179–82.

    Article  CAS  PubMed  Google Scholar 

  31. Buse DC, Pearlman SH, Reed ML, Serrano D, Ng-Mak DS, Lipton RB. Opioid use and dependence among persons with migraine: results of the AMPP study. Headache. 2012;52:18–36. This article assesses the frequency, comorbidities, and health care utilization of opioid use in migraine treatment based on data from the 2009 American Migraine Prevalence and Prevention Study (AMPP), a large US population-based sample.

  32. Webster BS, Verma SK, Gatchel RJ. Relationship between early opioid prescribing for acute occupational low back pain and disability duration, medical costs, subsequent surgery and late opioid use. Spine. 2007;32(19):2127–32.

    Article  PubMed  Google Scholar 

  33. Parks PD, Pranksy GS, Stefanos K. Case reports iatrogenic disability and narcotics addiction after lumbar fusion in a worker’s compensation claimant. Spine. 2010;35:549–52.

    Article  Google Scholar 

  34. Loder E, Weizenbaum E, Frishberg B, Silberstein S. Choosing wisely in headache medicine: the American Headache Society’s list of five things physicians and patients should question. Headache. 2013;53:1651–9.

    Article  PubMed  Google Scholar 

  35. Radat F, Lanteri-Minet M. What is the role of dependence related behavior in medication-overuse headache? Headache. 2010;50:1597–611.

    Article  PubMed  Google Scholar 

  36. Webster LR, Webster RM. Predicting aberrant behaviors in opioid-treated patients: preliminary validation of the opioid risk tool. Pain Med. 2007;6(6):432–42.

    Article  Google Scholar 

  37. Saper JR, Lake AE, Bain PA, Stillman MJ, Rothrock JF, Mathew NT, et al. A practice guide for continuous opioid therapy for refractory daily headache: patient selection, physician requirements, and treatment monitoring. Headache. 2010;50(7):1175–93.

    Article  PubMed  Google Scholar 

  38. Furlan AD, Reardon R, Weppler C. National Opioid Use Guideline Group Opioids for chronic noncancer pain: a new Canadian practice guideline. CMAJ. 2010;182(9):923–30.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Federation of State Medical Boards. Model Policy on the Use of Opioid Analgesics in the Treatment of Chronic Pain. 2013, 1-29. Available at: www.fsmb.org.

  40. Jamison RN, Mao J. Opioid analgesics. Mayo Clin Proc. 2015;90(7):957–68.

    Article  CAS  PubMed  Google Scholar 

  41. Andrasik F. Behavioral treatment approaches to chronic headache. Neurol Sci. 2003;24:80–5.

    Google Scholar 

  42. Holroyd KA, Drew JB. Behavioral approaches to the treatment of migraine. Semin Neurol. 2006;26:199–207.

    Article  PubMed  Google Scholar 

  43. Frich JC, Kristoffersen ES, Lundqvist C. GPs’ experiences with brief intervention for medication-overuse headache : a qualitative study in general practice. Br J Gen Pract. 2010;65:525–31.

    Google Scholar 

  44. Thorn BE, Pence LB, Ward LC, Kilgo G, Clements KL, Cross TH, et al. A randomized clinical trial of targeted cognitive behavioral treatment to reduce catastrophizing in chronic headache sufferers. J Pain. 2007;8:838949.

    Article  Google Scholar 

  45. Nestoriuc Y, Martin A. Efficacy of biofeedback for migraine: a meta-analysis. Pain. 2007;128:111–27.

    Article  PubMed  Google Scholar 

  46. Nestoriuc Y, Rief W, Martin A. Meta-analysis of biofeedback for tension-type headache: efficacy, specificity, and treatment moderators. J Consult Clin Psych. 2008;76:379–96.

    Article  Google Scholar 

  47. Jensen M, Nielson WR, Kerns RD. Toward the development of a motivational model of pain self-management. Journal of Pain. 2003;4:477–92.

    Article  PubMed  Google Scholar 

  48. Kerns RD, Burns JW, Shulman M, Jensen MP, Nielson WR, Czlapinski R, et al. Can we improve cognitive-behavioral therapy for chronic back pain treatment engagement and adherence? A controlled trial of tailored versus standard therapy. Health Psychol. 2014;33:938.

    Article  PubMed  Google Scholar 

  49. Crombez G, Ryckeghem DML, Eccleston C, Van Damme S. Attentional bias to pain-related information: a meta-analysis. Pain. 2013;154:497–510.

    Article  PubMed  Google Scholar 

  50. Miller WR, Rollnick S. Motivational interviewing: preparing people for change. 2nd ed. New York: Guilford Press; 2002.

    Google Scholar 

  51. Wetherell JL, Afari N, Rutledge T, Sorrell JT, Stoddard JA, Petkus AJ, et al. A randomized, controlled trial of acceptance and commitment therapy and cognitive behavioral therapy for chronic pain. Pain. 2011;152:2098–107.

    Article  PubMed  Google Scholar 

  52. Spoelstra SL, Schueller M, Hilton M, Ridenour M. Interventions combining motivational interviewing and cognitive behaviour to promote medication adherence: a literature review. J Clin Nurs. 2014;24:1163–73.

    Article  PubMed  Google Scholar 

  53. Nieuwlaat R, Wilczynski N, Navarro T, Hobson N, Jeffery R, Keepanasseril A, et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2012;11:1–730.

    Google Scholar 

  54. Zullig LL, Peterson ED, Bosworth HB. Ingredients of successful interventions to improve medication adherence. JAMA. 2013;310(24):2611–2.

    Article  CAS  PubMed  Google Scholar 

  55. Chang YP, Compton P, Almeter P, Fox CH. The effect of motivational interviewing on prescription opioid adherence among older adults with chronic pain. Perspect Psychiatr Care. 2015;51:211–9.

    Article  PubMed  Google Scholar 

  56. Berna C, Kulich RJ, Rathmell JP. Tapering long-term opioid therapy in chronic noncancer pain: evidence and recommendations for everyday practice. Mayo Clin Proc. 2015;90(6):828–42.

    Article  PubMed  Google Scholar 

  57. Townsend CO, Kerkvliet JL, Bruce BK, Rome JD, Hooten WM, Luedtke CA, et al. A longitudinal study of the efficacy of a comprehensive pain rehabilitation program with opioid withdrawal: comparison of treatment outcomes based on opioid use status at admission. Pain. 2008;140(1):177–89.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Melissa T. Stone.

Ethics declarations

Conflict of Interest

Melissa Stone, Valerie Weed, and Ronald J Kulich declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Psychological and Behavioral Aspects of Headache and Pain

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Stone, M.T., Weed, V. & Kulich, R.J. Opioid Treatment of Migraine: Risk Factors and Behavioral Issues. Curr Pain Headache Rep 20, 51 (2016). https://doi.org/10.1007/s11916-016-0581-9

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11916-016-0581-9

Keywords

Navigation