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The Link Between Infantile Colic and Migraine

  • Childhood and Adolescent Headache (S Evers, Section Editor)
  • Published:
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Abstract

Infantile colic is a self-limiting disorder of excessive infant crying or fussiness that peaks at 6 weeks of age and typically improves by 3 months of age. The etiology of infantile colic has yet to be definitively elucidated, but there is increasing research to support its relationship to migraine. The aims of this review are to present recent research investigating the connection between infantile colic and migraine. The importance of identifying this connection is useful in reducing invasive and potentially harmful investigations and to identify age appropriate pharmacologic interventions that would be safe in this population.

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Abbreviations

ICHD:

International classification of headache disorders

References

Papers of particular interest, published recently, have been highlighted as: •• Of major importance

  1. Headache Classification Committee of the International Headache S. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33:629–808.

    Article  Google Scholar 

  2. Gelfand AA. Episodic Syndromes That May Be Associated With Migraine: A.K.A. “the Childhood Periodic Syndromes”. Headache. 2015;55(10):1358–64.

  3. Sung V, Hiscock H, Tang ML, et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ. 2014;348:g2107. This study is the largest double blind, randomized placebo-controlled study for probiotic use in infantile colic. It showed probiotics were associated with increased crying in formula fed infants and was of no benefit for breast fed infants.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Lucassen P, Assendelft W, van Eijk JTM, Gubbels J, Douwes A, van Geldrop WJ. Systematic review of the occurrence of infantile colic in the community. Arch Dis Child. 2001;84:398–403.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Sillanpaa M, Saarinen M. Infantile colic associated with childhood migraine: a prospective cohort study. Cephalalgia. 2015;35:1246–51. This prospective, population-based study showed infantile colic is associated with an increased risk for migraine without aura, but not for migraine with aura.

    Article  PubMed  Google Scholar 

  6. Gelfand AA, Thomas KC, Goadsby PJ. Before the headache: infant colic as an early life expression of migraine. Neurology. 2012;79:1392–6.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Barr RG, Trent RB, Cross J. Age-related incidence curve of hospitalized shaken baby syndrome cases: convergent evidence for crying as a trigger to shaking. Child Abuse Negl. 2006;30:7–16.

    Article  PubMed  Google Scholar 

  8. Lee C, Barr RG, Catherine N, Wicks A. Age-related incidence of publicly reported shaken baby syndrome cases: is crying a trigger for shaking? J Dev Behav Pediatr : JDBP. 2007;28:288–93.

    Article  PubMed  Google Scholar 

  9. Barr RG. Preventing abusive head trauma resulting from a failure of normal interaction between infants and their caregivers. Proc Natl Acad Sci U S A. 2012;109:17294–301.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Pauli-Pott U, Becker K, Mertesacker T, Beckmann D. Infants with “Colic”—mothers’ perspectives on the crying problem. J Psychosom Res. 2000;48:125–32.

    Article  CAS  PubMed  Google Scholar 

  11. Romanello S, Spiri D, Marcuzzi E, et al. Association between childhood migraine and history of infantile colic. JAMA. 2013;309:1607–12.

    Article  CAS  PubMed  Google Scholar 

  12. Gelfand AA, Goadsby PJ, Allen IE. The relationship between migraine and infant colic: a systematic review and meta-analysis. Cephalalgia. 2015;35:63–72. This study is a systematic review and meta-analysis and finds an odds ratio of 6.5 (95 % CI, 4.6–8.9, p  < 0.001) for the association between migraine and infantile colic.

  13. Thomas DW, Greer FR, American Academy of Pediatrics Committee on N, American Academy of Pediatrics Section on Gastroenterology H, Nutrition. Probiotics and prebiotics in pediatrics. Pediatrics. 2010;126:1217–31.

    Article  PubMed  Google Scholar 

  14. Chau K, Lau E, Greenberg S, et al. Probiotics for infantile colic: a randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938. J Pediatr. 2015;166:74–8.

    Article  CAS  PubMed  Google Scholar 

  15. Savino F, Palumeri E, Castagno E, et al. Reduction of crying episodes owing to infantile colic: a randomized controlled study on the efficacy of a new infant formula. Eur J Clin Nutr. 2006;60:1304–10.

    Article  CAS  PubMed  Google Scholar 

  16. Rider JA. Decrease in defoaming potency of commercial simethicone antacid tablets over time. Curr Ther Res. 1992;52:681–5.

    Article  CAS  Google Scholar 

  17. Metcalf TJ, Irons TG, Sher LD, Young PC. Simethicone in the treatment of infant colic: a randomized, placebo-controlled, multicenter trial. Pediatrics. 1994;94:29–34.

    CAS  PubMed  Google Scholar 

  18. Porwal A, Mahajan AD, Oswal DS, et al. Efficacy and tolerability of fixed-dose combination of dexketoprofen and dicyclomine injection in acute renal colic. Pain Res Treat. 2012;2012:295926.

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Grunseit F. Evaluation of the efficacy of dicyclomine hydrochloride (‘Merbentyl’) syrup in the treatment of infant colic. Curr Med Res Opin. 1977;5:258–61.

    Article  CAS  PubMed  Google Scholar 

  20. Garriott JC, Rodriquez R, Norton LE. Two cases of death involving dicyclomine in infants. Measurement of therapeutic and toxic concentrations in blood. J Toxicol Clin Toxicol. 1984;22:455–62.

    Article  CAS  PubMed  Google Scholar 

  21. Gieruszczak-Bialek D, Konarska Z, Skorka A, Vandenplas Y, Szajewska H. No effect of proton pump inhibitors on crying and irritability in infants: systematic review of randomized controlled trials. J Pediatr. 2015;166:767–70. e763.

    Article  CAS  PubMed  Google Scholar 

  22. Orenstein SR, Hassall E, Furmaga-Jablonska W, Atkinson S, Raanan M. Multicenter, double-blind, randomized, placebo-controlled trial assessing the efficacy and safety of proton pump inhibitor lansoprazole in infants with symptoms of gastroesophageal reflux disease. J Pediatr. 2009;154:514–520.

  23. Belamarich PF, Bochner RE, Racine AD. A Critical Review of the Marketing Claims of Infant Formula Products in the United States. Clin Pediatr (Phila). 2015. doi:10.1177/0009922815589913

  24. Iacovou M, Ralston RA, Muir J, Walker KZ, Truby H. Dietary management of infantile colic: a systematic review. Matern Child Health J. 2012;16:1319–31.

    Article  PubMed  Google Scholar 

  25. Perry R, Hunt K, Ernst E. Nutritional supplements and other complementary medicines for infantile colic: a systematic review. Pediatrics. 2011;127:720–33.

    Article  PubMed  Google Scholar 

  26. Dobson D, Lucassen PL, Miller JJ, Vlieger AM, Prescott P, Lewith G. Manipulative therapies for infantile colic. Cochrane Database Syst Rev. 2012;12:CD004796.

    PubMed  Google Scholar 

  27. McKenzie S. Troublesome crying in infants: effect of advice to reduce stimulation. Arch Dis Child. 1991;66:1416–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Terrin G, Conte F, Oncel MY, et al. Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis. Arch Dis Childhood Fetal Neonatal Ed. 2016;101:127–36.

  29. Gulack BC, Laughon MM, Clark RH, Sankar MN, Hornik CP, Smith BP. Comparative effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus. Early Hum Dev. 2015;91:725–9.

    Article  CAS  PubMed  Google Scholar 

  30. Hamalainen ML, Hoppu K, Valkeila E, Santavuori P. Ibuprofen or acetaminophen for the acute treatment of migraine in children: a double-blind, randomized, placebo-controlled, crossover study. Neurology. 1997;48:103–7.

    Article  CAS  PubMed  Google Scholar 

  31. Evers S, Rahmann A, Kraemer C, et al. Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen. Neurology. 2006;67:497–9.

    Article  CAS  PubMed  Google Scholar 

  32. Ohlsson A, Shah PS. Paracetamol (acetaminophen) for prevention or treatment of pain in newborns. Cochrane Database Syst Rev. 2015;6:CD011219.

    PubMed  Google Scholar 

  33. Bauer AZ, Kriebel D. Prenatal and perinatal analgesic exposure and autism: an ecological link. Environ Health : Global Access Sci Sour. 2013;12:41.

    Article  Google Scholar 

  34. Viberg H, Eriksson P, Gordh T, Fredriksson A. Paracetamol (acetaminophen) administration during neonatal brain development affects cognitive function and alters its analgesic and anxiolytic response in adult male mice. Toxicol Sci : Off J Soc Toxicol. 2014;138:139–47.

    Article  CAS  Google Scholar 

  35. Akman I, Kuşçu K, Özdemir N, et al. Mothers’ postpartum psychological adjustment and infantile colic. Arch Dis Child. 2006;91:417–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Howard CR, Lanphear N, Lanphear BP, Eberly S, Lawrence RA. Parental responses to infant crying and colic: the effect on breastfeeding duration. Breastfeed Med. 2006;1:146–55.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. UCSF Pediatric Headache, San Francisco, CA, USA

    William Qubty & Amy A. Gelfand

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  1. William Qubty
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  2. Amy A. Gelfand
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Correspondence to William Qubty.

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Conflict of Interest

William Qubty declares no conflict of interest.

Amy A. Gelfand declares salary support from NIH/NCATS (8KL2TR000143-09) and grant support from the Migraine Research Foundation and UCSF CTSI. She has received research funding from EMKinetics and Allergan. She is on an advisory board for Eli Lilly and has received personal compensation for medical-legal consulting.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Childhood and Adolescent Headache

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Qubty, W., Gelfand, A.A. The Link Between Infantile Colic and Migraine. Curr Pain Headache Rep 20, 31 (2016). https://doi.org/10.1007/s11916-016-0558-8

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