Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence
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Cannabinoid compounds include phytocannabinoids, endocannabinoids, and synthetics. The two primary phytocannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), with CB1 receptors in the brain and peripheral tissue and CB2 receptors in the immune and hematopoietic systems. The route of delivery of cannabis is important as the bioavailability and metabolism are very different for smoking versus oral/sublingual routes. Gold standard clinical trials are limited; however, some studies have thus far shown evidence to support the use of cannabinoids for some cancer, neuropathic, spasticity, acute pain, and chronic pain conditions.
KeywordsMedical marijuana Chronic pain Cannabis Phytocannabinoids Endocannabinoids Neuropathic pain
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Conflict of Interest
Bjorn Jensen, Jeffrey Chen, Tim Furnish, and Mark Wallace each declare no potential conflicts of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
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