The pathogenesis of fibromyalgia (FM) and related conditions is not entirely understood. Recent evidence suggests that these syndromes may share heritable pathophysiologic features. Familial studies suggest that genetic and familial factors may play a role in the etiopathogenesis of these conditions. There is evidence that polymorphisms of genes in the serotoninergic and catecholaminergic systems are linked to the pathophysiology of FM and related conditions and are associated with personality traits. The precise role of genetic factors in the etiopathology of FM remains unknown, but it is likely that several genes are operating together to initiate this syndrome. Larger longitudinal studies are needed to better clarify the role of genetics in the development of FM.
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References and Recommended Reading
Wolfe F, Smythe HA, Yunus MB, et al.: The American College of Rheumatology criteria for the classification of fibromyalgia: report of the Multicenter Criteria Committee. Arthritis Rheum 1990, 33:160–172.
Neumann L, Buskila D: Epidemiology of fibromyalgia. Curr Pain Headache Rep 2003, 7:362–368.
Buskila D: Fibromyalgia: a bio-psychosocial syndrome. Isr Med Assoc J 2003, 5:887–888.
Buskila D, Neumann L, Press J: Genetic factors in neuromuscular pain. CNS Spectr 2005, 10:281–284. A useful review describing familial and genetic aspects of FM and related syndromes.
Clauw DJ, Crofford LJ: Chronic widespread pain and fibromyalgia: what we know and what we need to know. Best Pract Res Clin Rheumatol 2003, 17:685–701.
Roizenblatt S, Tufik S, Goldenberg J, et al.: Juvenile fibromyalgia: clinical and polysomnographic aspects. J Rheumatol 1997, 24:579–585.
Buskila D, Neumann L, Hazanov I, Carmi R: Familial aggregation in the fibromyalgia syndrome. Semin Arthritis Rheum 1996, 26:1–8.
Buskila D, Neumann L: Fibromyalgia syndrome (FM) and nonarticular tenderness in relatives of patients with FM. J Rheumatol 1997, 24:941–944.
Neumann L, Buskila D: Quality of life and physical functioning of relatives of fibromyalgic patients. Semin Arthritis Rheum 1997, 26:834–839.
Arnold LM, Hudson JI, Hess EV, et al.: Family study of fibromyalgia. Arthritis Rheum 2004, 50:944–952. The largest controlled study reporting that FM and reduced pressure pain thresholds aggregate in families and FM coaggregates with major mood disorder in families.
Barsky AJ, Borus JF: Functional somatic disorders. Ann Intern Med 1999, 130:910–921.
Hudson JI, Mangweth B, Pope HG Jr, et al.: Family study of affective spectrum disorder. Arch Gen Psychiatry 2003, 60:170–177.
Hudson JI, Arnold LM, Keck PE Jr, et al.: Family study of fibromyalgia and affective spectrum disorder. Biol Psychiatry 2004, 56:884–891.
Walsh CM, Zainal NZ, Middleton SJ, Paykel FS: A family history study of chronic fatigue syndrome. Psychiatr Genet 2001, 11:123–128.
Kalantar JS, Locke GR, Zinsmeister AR, et al.: Familial aggregation of irritable bowel syndrome: a prospective study. Gut 2003, 52:1703–1707. A prospective study reporting on familial aggregation of IBS.
Amir M, Kaplan Z, Neumann L, et al.: Post-traumatic stress disorder, tenderness, and fibromyalgia. J Psychosom Res 1997, 42:607–613.
Cohen H, Neumann L, Haiman Y, et al.: Prevalence of posttraumatic stress disorder in fibromyalgia patients: overlapping syndromes or post-traumatic fibromyalgia syndrome? Semin Arthritis Rheum 2002, 32:38–50.
Stein MB, Jang KL, Taylor S, et al.: Genetic and environment influences on trauma exposure and post-traumatic stress disorder symptoms: a twin study. Am J Psychiatry 2002, 159:1675–1681.
Segman RH, Shalev AY: Genetics of post-traumatic stress disorder. CNS Spectr 2003, 8:693–698.
Offenbaecher M, Bondy B, de Jonge S, et al.: Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis Rheum 1999, 42:2482–2488.
Bondy B, Spaeth M, Offenbaecher M, et al.: The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia. Neurobiol Dis 1999, 6:433–439.
Cohen H, Buskila D, Neumann L, Ebstein RP: Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5-HTTLPR) polymorphism, and relationship to anxiety-related personality traits. Arthritis Rheum 2002, 46:845–847.
Gursoy S, Erdal E, Herken H, et al.: Significance of catechol-Omethyltransferase gene polymorphism in fibromyalgia syndrome. Rheumatol Int 2003, 23:104–107.
Buskila D, Cohen H, Neumann L, Ebstein RP: An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits. Mol Psychiatry 2004, 9:730–731. This article reports on an association between FM and polymorphism in the dopaminergic system.
Narita M, Nishigami N, Narita N, et al.: Association between serotonin transporter gene polymorphism and chronic fatigue syndrome. Biochem Biophys Res Commun 2003, 311:264–266.
Camilleri M, Atanasova E, Carlson PJ, et al.: Serotonin transporter polymorphism pharmacogenetics in diarrheapredominant irritable bowel syndrome. Gastroenterology 2002, 123:425–432.
Segman RH, Cooper-Kazaz R, Macciardi F, et al.: Association between the dopamine transporter gene and post-traumatic stress disorder. Mol Psychiatry 2002, 7:903–907.
Lawford BR, McDyoung R, Noble EP, et al.: D2 dopamine receptor gene polymorphism: paroxetine and social functioning in posttraumatic stress disorder. Eur Neuropsychoparmacol 2003, 13:313–320.
Juhasz C, Zsombok T, Laszik A, et al.: Association analysis of 5-HTTLPR variants, 5-HT2a receptor gene 102 T/C polymorphism and migraine. J Neurgenet 2003, 17:231–240.
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Buskila, D., Neumann, L. Genetics of fibromyalgia. Current Science Inc 9, 313–315 (2005). https://doi.org/10.1007/s11916-005-0005-8
- Irritable Bowel Syndrome
- Chronic Fatigue Syndrome
- Familial Aggregation
- Fibromyalgia Syndrome