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Toward a molecular genetic classification of familial hemiplegic migraine

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Abstract

The genetics of migraine is a fascinating and rapidly moving research area. Familial hemiplegic migraine, a rare subtype of migraine with a Mendelian pattern of inheritance, is caused by mutations in the chromosome 19 CACNA1A gene or in the chromosome 1 ATP1A2 gene. Familial migraine variants are classified on the basis of clinical, descriptive criteria, but this is insufficient. In the future, a diagnostic classification based on mutationanalysis is needed.

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Authors and Affiliations

  1. Department of Neurology (K5Q), Leiden University Medical Centre, PO Box 9600, 2300, RC Leiden, The Netherlands

    Joost Haan MD, PhD, Esther E. Kors MD, Arn M. J. M. van den Maagdenberg PhD, Kaate R. J. Vanmolkot MSc, Gisela M. Terwindt MD, PhD, Rune R. Frants PhD & Michel D. Ferrari MD, PhD

Authors
  1. Joost Haan MD, PhD
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  2. Esther E. Kors MD
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  3. Arn M. J. M. van den Maagdenberg PhD
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  4. Kaate R. J. Vanmolkot MSc
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  5. Gisela M. Terwindt MD, PhD
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  6. Rune R. Frants PhD
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  7. Michel D. Ferrari MD, PhD
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Haan, J., Kors, E.E., van den Maagdenberg, A.M.J.M. et al. Toward a molecular genetic classification of familial hemiplegic migraine. Current Science Inc 8, 238–243 (2004). https://doi.org/10.1007/s11916-004-0058-0

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  • DOI: https://doi.org/10.1007/s11916-004-0058-0

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