Skip to main content

Advertisement

SpringerLink
Log in

Sporadic hemiplegic migraine

  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

Hemiplegic migraine may be familial or sporadic. Both forms share a similar spectrum of clinical presentations and genetic heterogeneity. Current data support the concept that sporadic and familial cases should be thought of as similar, but separate disorders. Sporadic cases are more difficult to diagnose and often require several investigations to rule out more ominous possibilities. Therapeutic options are limited, but future genetic research may elucidate pathophysiologic mechanisms that may, in turn, yield more specific treatments.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

erences and Recommended Reading

  1. Liveing E: On Megrim, Sick-Headache, and Some Allied Disorders. London: Churchill; 1873.

    Google Scholar 

  2. Whitty CW: Familial hemiplegic migraine. J Neurol Neurosurg Psychiatry 1953, 16:172–177.

    PubMed  CAS  Google Scholar 

  3. Headache Classification Committee of the International Headache Society: The international classification of headache disorders. Cephalalgia 2004, 24:29.

    Article  Google Scholar 

  4. Thomsen LL, Ostergaard E, Olesen J, Russell MB: Evidence for a separate type of migraine with aura. Neurology 2003, 60:595–601. This is the most complete assessment of the natural history of SHM. The authors distinguish ordinary from hemiplegic migraine based on the type of aura, not its duration.

    PubMed  Google Scholar 

  5. Terwindt G, Kors E, Haan J, et al.: Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic hemiplegic migraine. Arch Neurol 2002, 59:1016–1018. This is the largest series of SHM patients screened for genetic mutations and provides useful clinical data.

    Article  PubMed  Google Scholar 

  6. Thomsen LL, Eriksen MK, Romer SF, et al.: An epidemiological survey of hemiplegic migraine. Cephalalgia 2002, 22:361–375. This is the largest epidemiologic study on SHM.

    Article  Google Scholar 

  7. Bradshaw P, Parsons M: Hemiplegic migraine: a clinical study. Q J Med 1965, 34:65–86.

    PubMed  CAS  Google Scholar 

  8. Razavi M, Razavi B, Fattal D, et al.: Hemiplegic migraine induced by exertion. Arch Neurol 2000, 57:1363–1365.

    Article  PubMed  CAS  Google Scholar 

  9. Kors EE, Terwindt GM, Vermeulen FL, et al.: Delayed cerebral edema and fatal coma after minor head trauma: role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine. Ann Neurol 2001, 49:753–760.

    Article  PubMed  CAS  Google Scholar 

  10. Black DF, Swanson JW: Familial hemiplegic migraine and Erdheim-Chester disease [Abstract]. Headache 2002, 42:460–461.

    Google Scholar 

  11. Hayashi R, Tachikawa H, Watanabe R, et al.: Familial hemiplegic migraine with irreversible brain damage. Intern Med 1998, 37:166–168.

    PubMed  CAS  Google Scholar 

  12. Wada T, Kobayashi N, Takahashi Y, et al.: Wide clinical variability in a family with a CACNA1A T666M mutation: hemiplegic migraine, coma, and progressive ataxia. Pediatr Neurol 2002, 26:47–50.

    Article  PubMed  Google Scholar 

  13. Carrera P, Piatti M, Stenirri S, et al.: Genetic heterogeneity in Italian families with familial hemiplegic migraine. Neurology 1999, 53:26–33.

    PubMed  CAS  Google Scholar 

  14. Ophoff RA, Terwindt GM, Vergouwe MN, et al.: Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 1996, 87:543–552.

    Article  PubMed  CAS  Google Scholar 

  15. Ducros A, Denier C, Joutel A, et al.: The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel. N Engl J Med 2001, 345:17–24.

    Article  PubMed  CAS  Google Scholar 

  16. Berg MJ, Williams LS: The transient syndrome of headache with neurologic deficits and CSF lymphocytosis. Neurology 1995, 45:1648–1654.

    PubMed  CAS  Google Scholar 

  17. Parikh S, Swaiman KF, Kim Y: Neurologic characteristics of childhood lupus erythematosus. Pediatr Neurol 1995, 13:198–201.

    Article  PubMed  CAS  Google Scholar 

  18. Seleznick MJ, Silveira LH, Espinoza LR: Avascular necrosis associated with anticardiolipin antibodies. J Rheumatol 1991, 18:1416–1417.

    PubMed  CAS  Google Scholar 

  19. Bartleson JD, Krecke KN, O’Neill BP, Brown PD: Reversible, stroke-like migraine attacks in patients with previous radiation therapy. Neuro-oncol, 2003, 2:121–127. This is the first account in the adult literature of a little-known syndrome that may mimic complicated migraine.

    Article  Google Scholar 

  20. Koo B, Becker L, Chuang S, et al.: Mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes (MELAS): clinical, radiological, pathological, and genetic observations. Ann Neurol 1993, 34:25–32.

    Article  PubMed  CAS  Google Scholar 

  21. Steele JG, Nath PU, Burn J, Porteous ME: An association between migrainous aura and hereditary hemorrhagic telangiectasia. Headache 1993, 33:145–148.

    Article  PubMed  CAS  Google Scholar 

  22. de Grauw TJ, Smit LM, Brockstedt M, et al.: Acute hemiparesis as the presenting sign in a heterozygote for ornithine transcarbamylase deficiency. Neuropediatrics 1990, 21:133–135.

    PubMed  Google Scholar 

  23. Silva GS, Almeida CM, Felix EP, et al.: Cerebral venous thrombosis and homocystinuria: case report. Arq Neuropsiquiatr 2001, 59:815–816.

    PubMed  CAS  Google Scholar 

  24. Dora B, Balkan S: Sporadic hemiplegic migraine and Sturge-Weber syndrome. Headache 2001, 41:209–210.

    Article  PubMed  CAS  Google Scholar 

  25. Yu W, Horowitz SH: Treatment of sporadic hemiplegic migraine with calcium-channel blocker verapamil. Neurology 2003, 60:120–121.

    PubMed  Google Scholar 

  26. Fuentes B, Diez Tejedor E, Pascual J, et al.: Cerebral blood flow changes in pseudomigraine with pleocytosis analyzed by single photon emission computed tomography: A spreading depression mechanism? Cephalalgia 1998, 18:570–573.

    Article  PubMed  CAS  Google Scholar 

  27. DeBenedittis G, Ferrari DaPassano C, et al.: BF changes during headache-free periods and spontaneous/induced attacks in migraine with and without aura: a TCD and SPECT comparison study. J Neurosurg Sci 1999, 43:141–147.

    CAS  Google Scholar 

  28. Pascual J, Valle N. Pseudomigraine with lymphocytic pleocytosis. Curr Pain Headache Rep 2003, 7:224–228.

    PubMed  Google Scholar 

  29. Vahedi K, Denier C, Ducros A, et al.: CACANA1A gene de novo mutation causing hemiplegic migraine, coma, and cerebellar atrophy. Neurology 2000, 55:1040–1042.

    PubMed  CAS  Google Scholar 

  30. Chapman KM, Szczygielski BI, Toth C, et al.: Pseudomigraine with lymphocytic pleocytosis: A calcium channelopathy? Clinical description of 10 cases and genetic analysis of the familial hemiplegic migraine gene CACNA1A. Headache 2003, 43:892–895.

    Article  PubMed  Google Scholar 

  31. Arzimanoglou A, Aicardi J: The epilepsy of Sturge-Weber syndrome: clinical features and treatment in 23 patients. Acta Neurol Scand Suppl 1992, 140:18–22.

    Article  PubMed  CAS  Google Scholar 

  32. Ducros A, Denier C, Joutel A, et al.: Recurrence of the T666M calcium channel CACNA1A gene mutation in familial hemiplegic migraine with progressive cerebellar ataxia. Am J Hum Genet 1999, 64:89–98.

    Article  PubMed  CAS  Google Scholar 

  33. De Fusco M, Marconi R, Silvestri L, et al.: Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump a2 subunit associated with familial hemiplegic migraine type 2. Nat Genet 2003, 33:192–196.

    Article  PubMed  CAS  Google Scholar 

  34. Vanmolkot KR, Kors EE, Hottenga JJ, et al.: Novel mutations in the Na+, K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions. Ann Neurol 2003, 54:360–366.

    Article  PubMed  CAS  Google Scholar 

  35. Ducros A, Joutel A, Vahedi K, et al.: Mapping of second locus for familial hemiplegic migraine to 1q21-q23 and evidence of further heterogeneity. Ann Neurol 1997, 42:885–890.

    Article  PubMed  CAS  Google Scholar 

  36. Klapper J, Mathew N, Nett R: Triptans in the treatment of basilar migraine and migraine with prolonged aura. Headache 2001, 41:981–984.

    Article  PubMed  CAS  Google Scholar 

  37. Prendes JL: Consideration on use of propranolol in complicated migraine. Headache 1980, 20:93–95.

    Article  PubMed  CAS  Google Scholar 

  38. Gilbert GJ: An occurrence of complicated migraine during propranolol therapy. Headache 1982, 22:81–83.

    Article  PubMed  CAS  Google Scholar 

  39. Bardwell A, Trott J: Stroke in migraine as a consequence of propranolol. Headache 1987, 27:381–383.

    Article  PubMed  CAS  Google Scholar 

  40. Kaube H, Herzog J, Kaufer T, et al.: Aura in some patients with familial hemiplegic migraine can be stopped by intranasal ketamine. Neurology 2000, 55:139–141.

    Article  PubMed  CAS  Google Scholar 

  41. Rozen T: Treatment of a prolonged migrainous aura with intravenous furosemide. Neurology 2000, 55:732–733.

    PubMed  CAS  Google Scholar 

  42. Rozen T: Aborting a prolonged migrainous aura with intravenous prochlorperazine and magnesium sulfate. Headache 2003, 43:901–903.

    Article  PubMed  Google Scholar 

  43. Centonze V, Brucoli C, Macinagrossa G, et al.: Non-familial hemiplegic migraine responsive to naloxone. Cephalalgia 1983, 3:125–127.

    Article  PubMed  CAS  Google Scholar 

  44. Lastimosa AC: Treatment of sporadic hemiplegic migraine with calcium-channel blocker verapamil. Neurology 2003, 61:721–722.

    PubMed  Google Scholar 

  45. Dobrev D, Milde AS, Andreas K, Ravens U: The effects of verapamil and diltiazem on N-, P-and Q-type channels mediating dopamine release in rat striatum. Br J Pharmacol 1999, 127:576–582.

    Article  PubMed  CAS  Google Scholar 

  46. Tricarico D, Barberi M, Camerino DC: Acetazolamide opens the muscular KCa2+ channel: a novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis. Ann Neurol 2000, 48:304–312.

    Article  PubMed  CAS  Google Scholar 

  47. Athwal BS, Lennox GG: Acetazolamide responsiveness in familial hemiplegic migraine. Ann Neurol 1996, 40:820–821.

    Article  PubMed  CAS  Google Scholar 

  48. Battistini S, Stenirri S, Piatti M, et al.: A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia. Neurology 1999, 53:38–43.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA

    David F. Black MD

Authors
  1. David F. Black MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Black, D.F. Sporadic hemiplegic migraine. Current Science Inc 8, 223–228 (2004). https://doi.org/10.1007/s11916-004-0056-2

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11916-004-0056-2

Keywords

Search

Navigation