Abstract
Migraine is a major source of pain-related disability. Despite the personal and societal impact of this disorder, migraine continues to be misdiagnosed and undertreated even though well-established diagnostic criteria and safe and effective treatments are available. The recent revision of diagnostic criteria for headache diagnosis and consensus guidelines for migraine treatment hopefully will promote better medical care for headache sufferers. Advancements in understanding the neurobiology of migraine will guide the development of new treatments.
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References and Recommended Reading
Maetzel A, Li L: The economic burden of low back pain: a review of studies published between 1996 and 2001. Best Pract Res Clin Rheumatol 2002, 16:23–30.
Pop PH, Gierveld CM, Karis HA, Tiedink HG: Epidemiological aspects of headache in a workplace setting and the impact on the economic loss. Eur J Neurol 2002, 9:171–174.
Hu XH, Markson LE, Lipton RB, et al.: Burden of migraine in the United States: disability and economic costs. Arch Intern Med 1999, 159:813–818.
Lanteri-Minet M, Auray JP, El Hasnaui A, et al.: Prevalence and description of chronic daily headache in the general population of France. Pain 2003, 102:143–149.
Castillo J, Munoz P, Guitera V, Pasual J: Epidemiology of chronic daily headache in the general population. Headache 1998, 39:190–196.
Headache Classification Subcommittee of the International Headache Society: Classification and diagnostic criteria for headache disorders, cranial neuralgias, and facial pain. Cephalalgia 1988, 8:1–93.
Rasmussen BK, Jensen R, Olesen J: A population-based analysis of the diagnostic criteria of the International Headache Society. Cephalalgia 1991, 11:129–134.
Lipton RB, Cady RK, Stewart WF, et al.: Diagnostic lessons from the spectrum study. Neurology 2002, 58:S27-S31.
Lipton RB, Diamond S, Reed M, et al.: Migraine diagnosis and treatment: results from the American Headache Study II. Headache 2001, 41:638–645.
Lipton RB, Bigal ME, Kolodner K, et al.: The family impact of migraine: population based studies in the USA and UK. Cephalalgia 2003, 23:429–440.
Headache Classification Subcommittee of the International Headache Society: The international classification of headache disorders, edn 2. http://www.i-h-s.org. Comprehensive guidelines for headache diagnosis including background and commentary.
Mathew NT, Stubits E, Nigam MP: Transformation of episodic migraine into daily headache: analysis of factors. Headache 1982, 22:66–68.
Limmroth V, Katsarava Z, Fritsche G, et al.: Features of medication overuse headache following overuse of different acute headache drugs. Neurology 2002, 59:1011–1014.
Wang SJ, Fuh JL, Lu SR, et al.: Chronic daily headache in Chinese elderly. Neurology 2000, 54:314–319.
Silberstein SD, Lipton RB, Solomon S, Mathew N: Classification of daily and near-daily headaches: proposed revisions to the IHS criteria. Headache 1994, 34:1–7.
Diamond ML: The role of concomitant headache types and non-headache comorbidities in the underdiagnosis of migraine. Neurology 2002, 58:S3-S9.
Cady RK, Schreiber CP: Sinus headache or migraine? Considerations in making a differential diagnosis. Neurology 2002, 58:S10-S14.
Lipton RB, Stewart WF, Cady RK, et al.: Sumatriptan for the range of headache in migraine sufferers: results of the spectrum study. Headache 2000, 40:783–791.
Brennum J, Schriver L, Wanscher B, et al.: Sumatriptan has no clinically significant effect in the treatment of episodic tension type headache. Eur J Neurol 1996, 3:23–28.
Silberstein S: Practice parameter: evidenced-based guidelines for migraine headache (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2000, 55:754–762. Straightforward evidenced-based instructions for the care of the0 migraineur.
Goadsby PJ, Lipton RB, Ferrari MD: Migraine: current understanding and treatment. N Engl J Med 2002, 346:257–270.
Matchar DB, Young WB, Rosenberg JH, et al.: Evidenced-based guidelines for migraine headache in the primary care setting: pharmacological management of acute attacks. http:// www.aan.com 2000. Accessed November 1, 2003.
Lipton RB, Stewart WF, Stone AM, et al.: Stratified care vs step care strategies for migraine: the Disabilities in Strategies of Care Study group. JAMA 2002, 284:2599–2605.
Sculpher M, Millson D, Meddis D, Poole L: Cost-effectiveness analysis of stratified versus stepped care strategies for acute treatment of migraine: the Disability in Strategies for Care (DISC) Study. Pharmacoeconomics 2002, 20:91–100.
Maizels M, Saenz V, Wirjo J: Impact of a group-based model of disease management for headache. Headache 2003, 43:621–627.
Tfelt-Hansen P: Efficacy and adverse events of subcutaneous, oral, and intranasal sumatriptan used for migraine treatment: a systematic review based on number needed to treat. Cephalalgia 1998, 18:532–538.
Boyle R, Behan PO, Sutton JA: A correlation between severity of migraine and delayed gastric emptying measured by an epigastric impedance method. Br J Clin Pharmacol 1990, 30:405–409.
Package-Insert: Maxalt(rizatriptan benzoate) tablets and Maxalt-MLT(rizatriptan benzoate) orally disintegrating tablets. West Point, PA: Merck and Co, Inc; October 1998.
Ferrari MD, Roon KI, Lipton RB, Goadsby PJ: Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials. Lancet 2001, 358:1668–1675. Meta-analysis of triptan trials that provides criteria for choosing among the medications.
Cady RK, Lipton RB, Hall C, et al.: Treatment of mild headache in disabled migraine sufferers: results from the spectrum study. Headache 2000, 40:792–797.
Farkkila M, Olesen J, Dahlof C, et al.: Eletriptan in the treatment of migraine in patients with previous poor response to tolerance to oral sumatriptan. Cephalalgia 2003, 23:463–471.
Stark R, Spierings EL, McNeal S, et al.: Efficacy of naratriptan tablets in those who respond poorly to oral sumatriptan. Headache 2000, 40:513–520.
Ramadan NM, Silberstein S, Freitag FG, et al.: Evidence-based guidelines for migraine headache in the primary care setting: pharmacological management for the prevention of migraine. http://www.aan.com 2000. Accessed November 1, 2003.
Weiller C, May A, Limmroth V, et al.: Brain stem activation in spontaneous human migraine attacks. Nat Med 1995, 1:658–660.
Welch KM, Nagesh V, Aurora SK: Periaqueductal gray matter dysfunction in migraine: Cause or the burden of illness? Headache 2001, 41:629–637.
Raskin NH, Hosobuchi Y, Lamb S: Headache may arise from perturbation of brain. Headache 1987, 27:416–420.
Ambrosini A, de Noordhout A, Sandor PS, Schoenen J: Electrophysiological studies in migraine: a comprehensive view of their interest and limitations. Cephalalgia 2003, 23:13–31.
Valeriani M, de Tommaso M, Restuccia D, et al.: Reduced habituation to experimental pain in migraine patients: a CO(2) laser-evoked potential study. Pain 2003, 105:57–64.
Wray SH, Mijovic-Prelec D, Kosslyn SM: Visual processing in migraineurs. Brain 1995, 118:25–35.
Aurora SK, Ahmad BK, Welch KM, et al.: Transcranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine. Neurology 1998, 50:1111–1114.
Mayexsky A, Doron A, Manor T, et al.: Cortical spreading depression form the human brain using a multiparametric monitoring system. Brain Res 1996, 740:268–272.
Hadjikhani N, Sanchez Del Rio M, et al.: Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A 2001, 98:4687–4692.
Woods RP, Iacoboni M, Mazziotta JC: Brief report: bilateral spreading cerebral hypoperfusion during spontaneous migraine headache. N Engl J Med 1994, 331:1689–1692.
Bolay H, Reuter U, Dunn AK, et al.: Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 2002, 8:136–142.
Strassman AM, Raymond SA, Burstein R: Sensitization of meningeal sensory neurons and the origin of headaches. Nature 1996, 384:560–564.
Burstein R: Deconstructing migraine headache into peripheral and central sensitization. Pain 2001, 89:107–110. A concise, thought-provoking summary of the author’s groundbreaking research in migraine combining animal and human research.
Burstein R, Yamamura H, Malick A, Strassman AM: Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons. J Neurophysiol 1998, 79:964–982.
Burstein R, Yarnitsky D, Goor-Aryeh I, et al.: An association between migraine and cutaneous allodynia. Ann Neurol 2000, 47:614–624.
Burstein R, Collins B, Bajwa ZH, Jakubowski M: Triptan therapy can abort migraine attacks if given before the establishment or in the absence of cutaneous allodynia and central sensitization: clinical and preclinical evidence [Abstract]. Headache 2002, 42:390.
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Potrebic, S. The changing face of migraine. Current Science Inc 8, 85–90 (2004). https://doi.org/10.1007/s11916-004-0021-0
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DOI: https://doi.org/10.1007/s11916-004-0021-0