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The significance of the concept of obsessive-compulsive spectrum disorder to the treatment of chronic nonmalignant pain

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Abstract

The concept of an obsessive-compulsive spectrum of disorders has become useful. This article reviews what has been learned about these conditions (especially in the last few years), and how this information may be helpful to clinicians and researchers who work with patients with chronic nonmalignant pain.

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References and Recommended Reading

  1. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, edn 4. Washington, DC: American Psychiatric Association; 1994.

    Google Scholar 

  2. Allen A, Hollander E, guest eds: Obsessive-Compulsive Spectrum Disorders. Psychiatr Clin North Am 2000, 23(3):469–686. This is a relatively up-to-date issue devoted to OCD and related disorders, with contributions from many leaders in the field.

    Article  Google Scholar 

  3. Horwath E, Weissman MM: The epidemiology and crossnational presentation of obsessive-compulsive disorder. Psychiatr Clin North Am 2000, 23:493–507.

    Article  PubMed  CAS  Google Scholar 

  4. Piacentini J, Bergman RL: Obsessive-compulsive disorder in children. Psychiatr Clin North Am 2000, 23:519–533.

    Article  PubMed  CAS  Google Scholar 

  5. Nestadt G, Bienvenu OJ, Cai G, et al.: Incidence of obsessive-compulsive disorder in adults. J Nerv Ment Dis 1998, 186:401–406.

    Article  PubMed  CAS  Google Scholar 

  6. Stein MB, Forde DR, Anderson G, Walker JR: Obsessive-compulsive disorder in the community: an epidemiologic survey with clinical reappraisal. Am J Psychiatry 1997, 154:1120–1126.

    PubMed  CAS  Google Scholar 

  7. Eisen JL, Goodman WK, Keller MB, et al.: Patterns of remission and relapse in obsessive-compulsive disorder: a 2-year prospective study. J Clin Psychiatry 1999, 60:346–351.

    Article  PubMed  CAS  Google Scholar 

  8. Steketee G, Eisen J, Dyck I, et al.: Predictors of course in obsessive-compulsive disorder. Psychiatry Res 1999, 89:229–238.

    Article  PubMed  CAS  Google Scholar 

  9. Koran LM: Quality of life in obsessive-compulsive disorder. Psychiatr Clin North Am 2000, 23:509–517.

    Article  PubMed  CAS  Google Scholar 

  10. Nestadt G, Samuels J, Riddle M, et al.: A family study of obsessivecompulsive disorder. Arch Gen Psychiatry 2000, 57:358–363. This study provided strong evidence that OCD runs in families.

    Article  PubMed  CAS  Google Scholar 

  11. Wolff M, Alsobrook JP II, Pauls DL: Genetic aspects of obsessivecompulsive disorder. Psychiatr Clin North Am 2000, 3:535–544.

    Article  Google Scholar 

  12. Nestadt G, Lan T, Samuels J, et al.: Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex. Am J Hum Genet 2000, 67:1611–1616. This study provided powerful evidence that OCD has a genetic basis.

    Article  PubMed  CAS  Google Scholar 

  13. Leonard HL, Swedo SE: Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Int J Neuropsychopharmacol 2001, 4:191–198.

    Article  PubMed  CAS  Google Scholar 

  14. Lougee L, Perlmutter SJ, Nicolson R, et al.: Psychiatric disorders in first-degree relatives of children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. J Am Acad Child Adolesc Psychiatry 2000, 39:1120–1126.

    Article  PubMed  CAS  Google Scholar 

  15. Saxena S, Rauch SL: Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am 2000, 23:563–586.

    Article  PubMed  CAS  Google Scholar 

  16. Stein DJ: Advances in the neurobiology of obsessivecompulsive disorder: implications for conceptualizing putative obsessive-compulsive and spectrum disorders. Psychiatr Clin North Am 2000, 23:545–562.

    Article  PubMed  CAS  Google Scholar 

  17. Hollander E, Benzaquen SD: The obsessive-compulsive spectrum disorders. Int Rev Psychiatry 1997, 9:99–109.

    Article  Google Scholar 

  18. Bienvenu OJ, Samuels JF, Riddle MA, et al.: The relationship of obsessive-compulsive disorder to possible spectrum disorders: results from a family study. Biol Psychiatry 2000, 48:287–293. Showed that several of the commonly regarded OCSDs are familially related to OCD, particularly those on the "compulsive" end of the "compulsive-impulsive dimension."

    Article  PubMed  CAS  Google Scholar 

  19. Hollander E: Treatment of obsessive-compulsive spectrum disorders with SSRIs. Br J Psychiatry Suppl 1998, 35:7–12.

    PubMed  Google Scholar 

  20. Hollander E, Allen A, Kwon J, et al.: Clomipramine vs desipramine crossover trial in body dysmorphic disorder: selective efficacy of a serotonin reuptake inhibitor in imagined ugliness. Arch Gen Psychiatry 1999, 56:1033–1039. Demonstrated that BDD was, as previously believed, selectively responsive to an SRI (clomipramine), as opposed to a drug mainly acting on the noradrenergic system (desipramine). The same profile of response has been seen in OCD.

    Article  PubMed  CAS  Google Scholar 

  21. Hollander E, Buchalter AJ, DeCaria CM: Pathological gambling. Psychiatr Clin North Am 2000, 23:629–642.

    Article  PubMed  CAS  Google Scholar 

  22. Patterson WM, Bienvenu OJ, Chodynicki MP, et al.: Body dysmorphic disorder. Int J Dermatol 2001, in press.

  23. O’Sullivan RL, Mansueto CS, Lerner EA, Miguel EC: Characterization of trichotillomania: a phenomenological model with clinical relevance to obsessive-compulsive spectrum disorders. Psychiatr Clin North Am 2000, 23:587–604.

    Article  PubMed  CAS  Google Scholar 

  24. Grados MA, Riddle MA, Samuels JF, et al.: The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD Family Study. Biol Psychiatry 2001, 50:559–565.

    Article  PubMed  CAS  Google Scholar 

  25. Nestadt G, Samuels J, Riddle MA, et al.: The relationship between obsessive-compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study. Psychol Med 2001, 31:481–487. Assessed whether or not other psychiatric disorders should be considered part of the familial OCD spectrum. Several anxiety and unipolar depressive disorders occurred more frequently in relatives of persons with OCD than in relatives of controls. For many of these conditions, this relationship did not hold if OCD in the relative was controlled (ie, the other anxiety or depressive disorders appeared secondary). However, GAD occurred more frequently in relatives of persons with OCD, even in the absence of OCD itself.

    Article  PubMed  CAS  Google Scholar 

  26. Cullen BA, Samuels JF, Bienvenu OJ, et al.: Pathological skin picking and obsessive-compulsive disorder. J Nerv Ment Dis 2001, 189:193–195.

    Article  PubMed  CAS  Google Scholar 

  27. Samuels J, Nestadt G, Bienvenu OJ, et al.: Personality disorders and normal personality dimensions in obsessive-compulsive disorder: results from the Johns Hopkins OCD Family Study. Br J Psychiatry 2000, 177:457–462. Showed that elevated obsessive-compulsive personality traits and elevated neuroticism were characteristic of relatives of persons with OCD, suggesting that these personality features are also part of the familial OCD spectrum.

    Article  PubMed  CAS  Google Scholar 

  28. Fallon BA, Qureshi AI, Laje G, Klein B: Hypochondriasis and its relationship to obsessive-compulsive disorder. Psychiatr Clin North Am 2000 23:605–616.

    Article  PubMed  CAS  Google Scholar 

  29. Noyes RJr.: The relationship of hypochondriasis to anxiety disorders. Gen Hosp Psychiatry 1999, 21:8–17.

    Article  PubMed  Google Scholar 

  30. Keyser JJ: Clomipramine for obsessive pain-type syndromes. Plast Reconstr Surg 1992, 89:166.

    PubMed  CAS  Google Scholar 

  31. Fishbain DA, Trescott J, Cutler B, et al.: Do some chronic pain patients with atypical facial pain overvalue and obsess about their pain? Psychosomatics 1993, 34:355–359.

    PubMed  CAS  Google Scholar 

  32. Keuler DJ, Altemus M, Michelson D, et al.: Behavioral effects of naloxone infusion in obsessive-compulsive disorder. Biol Psychiatry 1996, 40:154–156.

    Article  PubMed  CAS  Google Scholar 

  33. Goldsmith TD, Shapira NA, Keck PE: Rapid remission of OCD with tramadol hydrochloride. Am J Psychiatry 1999, 156:660–661.

    PubMed  CAS  Google Scholar 

  34. Friedman I, Dar R, Shilony E: Compulsivity and obsessionality in opioid addiction. J Nerv Ment Dis 2000, 188:155–162.

    Article  PubMed  CAS  Google Scholar 

  35. Kurlan R, Majumdar L, Deeley C, et al.: A controlled trial of propoxyphene and naltrexone in patients with Tourette’s syndrome. Ann Neurol 1991, 30:19–23.

    Article  PubMed  CAS  Google Scholar 

  36. Warneke L: A possible new treatment approach to obsessivecompulsive disorder. Can J Psychiatry 1997, 42:667–668.

    PubMed  CAS  Google Scholar 

  37. Hollander E, Kaplan A, Allen A, Cartwright C: Pharmacotherapy for obsessive-compulsive disorder. Psychiatr Clin North Am 2000, 23:643–656.

    Article  PubMed  CAS  Google Scholar 

  38. McDougle CJ, Epperson CN, Pelton GH, et al.: A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. Arch Gen Psychiatry 2000, 57:794–801. Showed that a dopamine antagonist, risperidone, was useful in the treatment of OCD in patients without tics (previous work showed the efficacy of low-dose dopamine antagonists in OCD with tics and in tic disorders in general). It is not yet clear whether or not the use of low-dose dopamine antagonists in patients with OCD will result in an increased prevalence of long-term complications like tardive dyskinesia.

    Article  PubMed  CAS  Google Scholar 

  39. Neziroglu F, Hsia C, Yaryura-Tobias JA: Behavioral, cognitive, and family therapy for obsessive-compulsive and related disorders. Psychiatr Clin North Am 2000, 23:657–670.

    Article  PubMed  CAS  Google Scholar 

  40. Greenberg BD, Murphy DL, Rasmussen SA: Neuroanatomically based approaches to obsessive-compulsive disorder: neurosurgery and transcranial magnetic stimulation. Psychiatr Clin North Am 2000, 23:671–686.

    Article  PubMed  CAS  Google Scholar 

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Bienvenu, O.J., Cannistraro, P.A. The significance of the concept of obsessive-compulsive spectrum disorder to the treatment of chronic nonmalignant pain. Current Science Inc 6, 40–43 (2002). https://doi.org/10.1007/s11916-002-0022-9

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  • DOI: https://doi.org/10.1007/s11916-002-0022-9

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