Abstract
The use of over-the-counter-medication in migraine treatment is commonplace. They are often used in addition to physician-prescribed medications and may be used without the full knowledge of the physician. Although considerable evidence suggests their efficacy in migraine treatment, they are rarely used to maximal levels of efficacy and safety. A review of the evidence for these treatments is important for cost effective, well-tolerated, and specific treatment of migraine headache.
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References and Recommended Reading
Boureau F, Joubert JM, Lasserre V, et al.: Double-blind comparison of an acetaminophen 400 mg-codeine 25 mg combination versus aspirin 1000 mg and placebo in acute migraine attack. Cephalalgia 1994, 14:156–161.
Tfelt-Hansen P, Olesen J: Effervescent metoclopramide and aspirin (Migravess) versus effervescent aspirin or placebo for migraine attacks: a double-blind study. Cephalalgia 1984, 4:107–111.
Lange R, Schwarz JA, Hohn M: Acetylsalicylic acid effervescent 1000 mg (aspirin) in the acute migraine attacks; a multicenter, randomized, double blind, single-dose, placebocontrolled parallel group study. Cephalalgia 2000, 20:663–667.
Oral Sumatriptan and Aspirin-plus-Metoclopramide Comparative Study Group: A study to compare oral sumatriptan with oral aspirin plus oral metoclopramide in the acute treatment of migraine. Eur Neurol 1992, 32:177–184.
Larsen BH, Christiansen LV, Andersen B, Olesen J: Randomized double-blind comparison of tolfenamic acid and paracetamol in migraine. Acta Neurol Scand 1990, 81:464–467.
Pearce I, Frank GJ, Pearce JM: Ibuprofen compared with paracetamol in migraine. Practitioner 1983, 227:465–467.
Lipton RB, Baggish JS, Stewart WF, et al.: Efficacy and safety of acetaminophen in the treatment of migraine. Arch Intern Med 2000, 160:3486–3492.
Hämäläinen MJ, Hoppu K, Valkeila E, Santavuori P: Ibuprofen or acetaminophen for the acute treatment of migraine in children. Neurology 1997, 48:103–107.
Nebe J, Heier M, Diener HC: Low-dose ibuprofen in selfmedication of mild to moderate headache: a comparison with acetylsalicylic acid and placebo. Cephalalgia 1995, 15:531–535.
Sandrini G, Franchini S, Lanfranchi S, et al.: Effectiveness of ibuprofen-arginine in the treatment of acute migraineattacks. Int J Clin Pharm Res 1998, 18:145–150.
Kellstein DE, Lipton RB, Geetha R, et al.: Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double blind, placebocontrolled, dose-ranging study. Cephalalgia 2000, 20:233–243.
Lipton RB, Stewart WF, Ryan RE Jr., et al.: Efficacy and safety of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain. Arch. Neurol 1998, 55:210–217. This combination agent is the first to receive an FDA label for migraine specific treatment in the over-the-counter market.
Diamond S, Balm TK, Freitag FG: Ibuprofen plus caffeine in the treatment of tension-type headache. Clin Pharmacol Ther 2000, 68:312–319.
Goldstein J, Hoffman HD, Armellino JJ, et al.: Treatment of severe, disabling migraine attacks in an over-the-counter population of migraine sufferers: results from three randomized, placebo-controlled studies of the combination of acetaminophen, aspirin and caffeine. Cephalalgia 1999, 19:684–691.
Silberstein SD, Armellino JJ, Hoffman HD, et al.: Treatment of menstruation-associated migraine with the nonprescription combination of acetaminophen, aspirin and caffeine: results from three randomized placebo-controlled studies. ClinTher 1999, 21:475–491.
Migliardi, JR, Armellino JJ, Friedman M, et al.: Caffeine as an analgesic adjuvant in tension headache. Clin Pharmacol Ther 1994, 56:576–586.
O’Neill BP, Mann JD: Aspirin prophylaxis in migraine. Lancet 1978, 2:1179–1181.
Buring JE, Peto R, Hennekens CH: Low dose aspirin for migraine prophylaxis. JAMA 1990, 264:1711–1713.
Bensenor IM, Cook, NR, Lee, IM, et al.: Low-dose aspirin for migraine prophylaxis in women. Cephalalgia 2001, 21:167–168.
Vogler BK, Pittler MH, Ernst E: Feverfew as preventive treatment for migraine: a systematic review. Cephalalgia 1998, 18:704–708. Comprehensive review of feverfew as a migraine treatment.
Silberstein S: Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review). Neurology 2000, 55:754–762. This is a concise version of the evidence-based medicine comprehensive guidelines found on the American Academy of Neurology website.
Pfaffenrath V, Wessely P, Meyer C, et al.: Magnesium in the prophylaxis of migraine: a double-blind, placebo-controlled study. Cephalalgia 1996, 16:436–440.
Peikert A, Wilimzig C, Köhne-Volland R: Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized trial. Cephalalgia 1996, 16:257–263.
Facchinetti F, Sances G, Borella P, et al.: Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache 1991, 31:298–301.
Schoenen J, Lenaerts M, Bastings E: High-dose riboflavin as a prophylactic treatment of migraine: results of an open pilot study. Cephalalgia 1994, 14:328–329.
Schoenen J, Jacguy J, Lenaerts M: Effectiveness of high-dose riboflavin in migraine prophylaxis a randomized controlled trial. Neurology 1998, 50:466–470.
Grossman M, Schmidramsl H: An extract of Petasites hybridus is effective in the prophylaxis of migraine. Int J Clin Pharmacol Ther 2000, 38:430–435.
Whitmarsh TE, Coleston-Shields DM, Steiner TJ: Double-blind randomized placebo-controlled study of homeopathic prophylaxis of migraine. Cephalalgia 1997, 17:600–604.
Straumsheim P, Borchgrevink C, Mowinckel P, et al.: Homeopathic treatment of migraine: a double blind placebo controlled trial of 68 patients. Br Homeopath J 2000, 89:4–7.
Edmeads J, Findlay H, Tugwell P, et al.: Impact of migraine and tension-type headache on life style, consulting behavior, and medication use: a Canadian population survey. Can J Neurol Sci 1993, 20:131–137.
Stewart WF, Lipton RB: Migraine headache: epidemiology and health care utilization. Cephalalgia 1993, 13(suppl12):41–46.
Forward SP, McGrath PJ, MacKinnon D, et al.: Medication patterns of recurrent headache sufferers: a community study. Cephalalgia 1998, 18:146–151.
Elkind A: Drug abuse and headache. Med Clin North Am 1991, 75:717–732.
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Freitag, F.G. Do Over-the-counter medications help the physician manage migraine headache?. Current Science Inc 6, 156–161 (2002). https://doi.org/10.1007/s11916-002-0013-x
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DOI: https://doi.org/10.1007/s11916-002-0013-x