The use of ibuprofen plus caffeine to treat tension-type headache
- 290 Downloads
Simple analgesics such as ibuprofen, aspirin, and acetaminophen have long been used in the treatment of tension-type headache. Studies of combination agents of aspirin with caffeine or acetaminophen with caffeine have also demonstrated efficacy as analgesic agents. Other evidence also suggests that caffeine may have an analgesic effect unto itself in the relief of pain. We undertook the direction of a multicenter, double-blind, placebo-controlled, parallel trial to assess the efficacy and safety of ibuprofen combined with caffeine in the treatment of tension-type headache. The study was designed to also verify the analgesic efficacy of caffeine and further assess the role of tension-type headache as a model for the study of pain.
KeywordsCaffeine Ibuprofen Pain Relief International Headache Society Analgesic Efficacy
Unable to display preview. Download preview PDF.
References and Recommended Reading
- 6.Vecchio TJ, Heilman CJ, O’Connell MJ: Efficacy of ibuprofen in muscle contraction headache [abstract]. Clin Pharmacol Ther 1983, 33:199.Google Scholar
- 10.Steiner TJ, Lange R: Ketoprofen (25 mg) in the symptomatic treatment of episodic tension-type headache: double blind placebo-controlled comparison with acetaminophen (1000 mg). Cephalalgia 1998, 18:38–43. This is one of the recent studies to examine simple analgesics using the tension-type headache model.PubMedCrossRefGoogle Scholar
- 11.Packman B, Packman E, Doyle E, et al.: Solubilized ibuprofen: Evaluation of onset, relief and safety of a noel formulation in the treatment of episodic tension-type headache. Headache 2000, 40:561–567. This study of simple analgesic treatment of tension-type headache used similar newer modalities for assessment of pain in the tensiontype headache module. It verified many of the methods that were used in the studies, discussed in detail in this paper.PubMedCrossRefGoogle Scholar
- 19.Diamond S, Balm TK, Freitag FG: Ibuprofen plus caffeine in the treatment of tension-type headache. Clin Pharmacol Ther 2000, 68:312–319. This study was important for several reasons. First, it used the newer methods for assessing pain in the setting of tension-type headache. Thus validating the current modern techniques of pain assessment and verifying the potential for tension-type headache to be used as a model for measuring pain. Additionally, it demonstrated clearly that caffeine does indeed have analgesic activity that can be differentiated from that of established analgesics.PubMedCrossRefGoogle Scholar
- 20.Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society [no authors listed]. Cephalalgia 1988, 8(suppl 7):1–96.Google Scholar
- 21.SAS Institute Inc. SAS/STAT User’s Guide, version 6, edn 4, vol 1. Cary, NC: SAS Institute Inc.; 1989.Google Scholar