Abstract
Purpose of Review
Diabetes mellitus is a prevalent chronic disease affecting millions of people in the world. Bone fragility is a complication found in diabetic patients. Although osteoblasts and osteoclasts are directly affected by diabetes, herein we focus on how the diabetic state—based on hyperglycemia and accumulation of advanced glycation end products among other features—impairs osteocyte functions exerting deleterious effects on bone.
Recent Findings
In the last years, several studies described that diabetic conditions cause morphological modifications on lacunar-canalicular system, alterations on osteocyte mechanoreceptors and intracellular pathways and on osteocyte communication with other cells through the secretion of proteins such as sclerostin or RANKL.
Summary
This article gives an overview of events occurring in diabetic osteocytes. In particular, mechanical responses seem to be seriously affected in these conditions, suggesting that mechanical sensibility could be a target for future research in the field.
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This study was supported by Ministerio de Ciencia, Innovación y Universidades (SAF2016-80286).
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Arancha Gortazar and Juan Ardura declare no conflict of interest.
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Gortázar, A.R., Ardura, J.A. Osteocytes and Diabetes: Altered Function of Diabetic Osteocytes. Curr Osteoporos Rep 18, 796–802 (2020). https://doi.org/10.1007/s11914-020-00641-z
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DOI: https://doi.org/10.1007/s11914-020-00641-z