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Mechanisms Underlying Bone and Joint Pain

  • Bone and Joint Pain (T King and S Amin, Section Editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The goal of this review is to provide a broad overview of the current understanding of mechanisms underlying bone and joint pain.

Recent Findings

Bone or joint pathology is generally accompanied by local release of pro-inflammatory cytokines, growth factors, and neurotransmitters that activate and sensitize sensory nerves resulting in an amplified pain signal. Modulation of the pain signal within the spinal cord and brain that result in net increased facilitation is proposed to contribute to the development of chronic pain.

Summary

Great strides have been made in our understanding of mechanisms underlying bone and joint pain that will guide development of improved therapeutic options for these patients. Continued research is required for improved understanding of mechanistic differences driving different components of bone and/or joint pain such as movement related pain compared to persistent background pain. Advances will guide development of more individualized and comprehensive therapeutic options.

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Authors and Affiliations

  1. Center for Excellence in the Neurosciences, University of New England, Biddeford, ME, 04043, USA

    Joshua Havelin & Tamara King

  2. Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, 04469, USA

    Joshua Havelin & Tamara King

  3. Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, 11 Hills Beach Rd., Biddeford, ME, 04005, USA

    Tamara King

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This article is part of the Topical Collection on Bone and Joint Pain

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Havelin, J., King, T. Mechanisms Underlying Bone and Joint Pain. Curr Osteoporos Rep 16, 763–771 (2018). https://doi.org/10.1007/s11914-018-0493-1

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