Abstract
Bone metastatic disease remains a significant and frequent problem for cancer patients that can lead to increased morbidity and mortality. Unfortunately, despite decades of research, bone metastases remain incurable. Current studies have demonstrated that many properties and cell types within the bone and bone marrow microenvironment contribute to tumor-induced bone disease. Furthermore, they have pointed to the importance of understanding how tumor cells interact with their microenvironment in order to help improve both the development of new therapeutics and the prediction of response to therapy.
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Denise Buenrostro, Patrick L. Mulcrone, Philip Owens, and Julie A. Sterling declare that they have no conflict of interest.
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With regard to the authors’ research cited in this paper, all institutional and national guidelines for the care and use of laboratory animals were followed. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Buenrostro, D., Mulcrone, P.L., Owens, P. et al. The Bone Microenvironment: a Fertile Soil for Tumor Growth. Curr Osteoporos Rep 14, 151–158 (2016). https://doi.org/10.1007/s11914-016-0315-2
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DOI: https://doi.org/10.1007/s11914-016-0315-2