Skip to main content

Advertisement

SpringerLink
Log in

Ductal lavage in the screening of high-risk women

  • Published:
Current Oncology Reports Aims and scope Submit manuscript

Abstract

Due to the high incidence of breast cancer and the excessively high false-positive rate of current screening technologies, adjunctive risk assessment measures are needed. Nipple aspiration cytologic analysis and random fine-needle aspirations have been proposed; however, ductal lavage and cytologic analysis of the effluent is a more sensitive and specific test. The dilemma lies in what should be done subsequent to a ductal lavage yielding malignant or atypical cells. The procedures and potential management strategies are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References and Recommended Reading

  1. London SJ, Connelly JL, Schnitt SJ, Colditz GA: A prospective study of benign breast disease and the risk of breast cancer. JAMA 1992, 267:941–944.

    Article  PubMed  CAS  Google Scholar 

  2. McTiernan A, Gilligan MA, Redmond C, et al.: Assessing individual risk for breast cancer: risky business. J Clin Epidemiol 1997, 50:547–556.

    Article  PubMed  CAS  Google Scholar 

  3. Fisher B, Costantino JP, Wickerham DL, et al.: Tamoxifen for the prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Nat Cancer Inst 1998, 90:1371–1388. Landmark paper on tamoxifen decreasing breast cancer risk in high-risk patients.

    Article  PubMed  CAS  Google Scholar 

  4. Hartmann LC, Schaid DJ, Woods JE, et al.: Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer. N Eng J Med 1999, 14:77–84. Nice evaluation of the benefit of prophylactic mastectomy.

    Article  Google Scholar 

  5. Elmore JG, Barton MB, Moceri VM, et al.: Ten-year risk of false positive screening mammograms and clinical breast examinations. N Engl J Med 1998, 338:1089–1096.

    Article  PubMed  CAS  Google Scholar 

  6. Wrensch MR, Petrakis NL, King EB, et al.: Breast cancer incidence in women with abnormal cytology in nipple aspirates of breast fluid. Am J Epidemiol 1992, 135:130–141.

    PubMed  CAS  Google Scholar 

  7. Dooley WC, Ljung BM, Veronesi U, et al.: Ductal lavage for detection of cellular atypia in women at high risk for breast cancer. J Natl Cancer Inst 2001, 92:1624–1632. Original ductal lavage literature.

    Google Scholar 

  8. Costantino JP, Gail MH, Pee D, et al.: Validation studies for models projecting the risk of invasive and total breast cancer incidence. J Natl Cancer Inst 1999, 91:1541–1548.

    Article  PubMed  CAS  Google Scholar 

  9. Spiegelman D, Colditz GA, Hunter D, Hertzmark E: Validation of the Gail et al. model for predicting individual breast cancer risk. J Natl Cancer Inst 1994, 86:600–607.

    Article  PubMed  CAS  Google Scholar 

  10. Rockhill B, Spiegelman D, Bryne C, et al.: Validation of the Gail et al. model of breast cancer risk prediction and implications for chemoprevention. J Natl Cancer Inst 2001, 93:358–366. A nice explanation of the Gail model.

    Article  PubMed  CAS  Google Scholar 

  11. Fabian CJ, Kimler BF, Zalles CM, et al.: Short-term breast cancer prediction by random periareolar fine-needle aspiration cytology and the Gail risk model. J Natl Cancer Inst 2000, 92:1217–1227.

    Article  PubMed  CAS  Google Scholar 

  12. Ward JH, Marshall CJ, Schuman GB, et al.: Detection of proliferative breast disease by four-quadrant, fine-needle aspiration. J Natl Cancer Inst 1990, 82:964–966.

    Article  PubMed  CAS  Google Scholar 

  13. Khan SA, Masood S, Numann PJ: Random fine needle aspiration of the breast of women at increased breast cancer risk and standard risk controls. Breast J 1998, 4:420–425.

    Article  Google Scholar 

  14. Wrensch MR, Petrakis NL, Miike R, et al.: Breast cancer risk in woman with abnormal cytology in nipple aspirates of breast fluid. J Natl Cancer Inst 2001, 93:1791–1798.

    Article  PubMed  CAS  Google Scholar 

  15. Shen KW, Wu J, Lu JS, et al.: Fiberoptic ductoscopy for breast cancer patients with nipple discharge. Surg Endosc 2001, 15:1340–1345.

    Article  PubMed  CAS  Google Scholar 

  16. Evron E, Dooley WC, Umbricht CB, et al.: Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR. Lancet 2001, 357:1335–1336. An interesting molecular genetics application with potential benefit for patients with abnormal cells on ductal lavage.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Women’s Cancer Center Los Angeles, Queen of Angels-Hollywood Presbyterian Medical Center, 1300 North Vermont Avenue, 90027, Los Angeles, CA, USA

    Margarett C. Ellison MD

Authors
  1. Patrick J. Kenney DO
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Margarett C. Ellison MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kenney, P.J., Ellison, M.C. Ductal lavage in the screening of high-risk women. Curr Oncol Rep 6, 69–73 (2004). https://doi.org/10.1007/s11912-996-0012-x

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11912-996-0012-x

Keywords

Search

Navigation