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New Directions in Vulvar Cancer Pathology

  • Gynecologic Cancers (NS Reed, Section Editor)
  • Published:
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Abstract

Purpose of Review

The aim of this article is to provide clinicians and pathologists with an understanding of the aetiopathology, pathogenesis and classification of vulval neoplasia and their molecular correlates.

Recent Findings

There is an increased understanding of subcellular changes in vulvar malignancies. These provide the direction for further research and aid personalised treatment for patients.

Summary

The article explores concepts of the aetiology of vulvar cancer and updates the reader with the equivalence of terminology of preneoplastic vulval disease. The differential diagnosis of squamous neoplasia and their clinicopathological correlation is detailed. The salient findings from recent literature into the understanding of the disease of squamous cell neoplasia and rare vulvar malignancies are summarised.

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Papers of particular interest, published recently, have been highlighted as: • Of importance

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Authors and Affiliations

  1. Birmingham Women’s and Children’s NHS Foundation Trust, 1st Floor Labs, Mindelsohn Way, Birmingham, B15 2TG, UK

    Anthony Williams & Raji Ganesan

  2. Pathology Department, Queen Elizabeth University Hospital Glasgow, 1345 Govan Road, Laboratory Medicine and Facility Building, Glasgow, G51 4TF, UK

    Sheeba Syed

  3. University Hospitals Birmingham NHS Foundation Trust, Mindelsohn Way, Birmingham, B15 2TG, UK

    Shireen Velangi

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  1. Anthony Williams
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  4. Raji Ganesan
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Correspondence to Raji Ganesan.

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Conflict of Interest

Anthony Williams declares that he has no conflict of interest.

Sheeba Syed declares that she has no conflict of interest.

Shireen Velangi has received honoraria for the preparation of vulval dermatology lectures delivered during dermatology courses throughout the UK. These courses are run by Guy’s and St. Thomas’ NHS Foundation Trust, in association with the British Association of Dermatologists, University Hospitals Birmingham and Birmingham Children’s Hospital.

Raji Ganesan declares that she has no conflict of interest.

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Williams, A., Syed, S., Velangi, S. et al. New Directions in Vulvar Cancer Pathology. Curr Oncol Rep 21, 88 (2019). https://doi.org/10.1007/s11912-019-0833-z

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