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Peritoneal Metastases from Gastrointestinal Cancer

  • Gastrointestinal Cancers (J Meyer, Section Editor)
  • Published:
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Abstract

Purpose of Review

Peritoneal metastases may occur from a majority of cancers that occur within the abdomen or pelvis. When cancer spread to the peritoneal surfaces is documented, a decision regarding palliation vs. an aggressive approach using cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy must be made. The perioperative chemotherapy may be hyperthermic intraperitoneal chemotherapy (HIPEC) administered in the operating room or early postoperative intraperitoneal chemotherapy (EPIC) administered in the first 4 or 5 postoperative days.

Recent Findings

This decision is dependent on a well-defined group of prognostic indicators. In addition to treatment, the clinical and pathologic features of a primary cancer can be used to select perioperative treatments that may prevent cancer cells within the abdomen and pelvis from progressing to established peritoneal metastases. In some clinical situations with appendiceal and colorectal cancers, the clinical or histopathologic features may indicate that second-look surgery plus perioperative chemotherapy should occur.

Summary

Peritoneal metastases should always be considered for treatment or prevention.

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  1. Center for Gastrointestinal Malignancies, MedStar Washington Hospital Center, 106 Irving St., NW, Suite 3900, Washington, DC, 20010, USA

    Paul H. Sugarbaker

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Sugarbaker, P.H. Peritoneal Metastases from Gastrointestinal Cancer. Curr Oncol Rep 20, 62 (2018). https://doi.org/10.1007/s11912-018-0703-0

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