Electrophysiologic Toxicity of Chemoradiation

  • Merna A. Armanious
  • Shreya Mishra
  • Michael G. Fradley
Cardio-oncology (EH Yang, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Cardio-oncology


Purpose of Review

There is growing awareness of the link between oncology treatments and cardiovascular (CV) complications. This has led to the development of cardio-oncology, a specialty aimed at managing CV risk and disease in cancer patients and survivors. Cardiac arrhythmias are potential adverse CV complications of cancer treatments; however, these cardiotoxicities are often underappreciated due to the uncertain arrhythmogenic mechanisms of various chemotherapeutic agents.

Recent Findings

Chemotherapeutic agents can induce arrhythmias via direct electrophysiological effects on ion channels or intracellular signaling pathways, or indirectly from cardiac tissue damage.


As more drugs are being linked to the development of arrhythmias, a deeper understanding of the pathophysiology of their electrophysiological (EP) effects will be necessary. Expanding research in this field has allowed for the identification of novel agents with potential arrhythmogenic properties and the development of preventative measures, early recognition, and closer surveillance of patients more susceptible to these EP side effects.


Arrhythmias Chemotherapy Cardio-oncology QT prolongation 


Compliance with Ethical Standards

Conflict of Interest

Merna A. Armanious declares that she has no conflict of interest.

Shreya Mishra declares that she has no conflict of interest.

Michael G. Fradley has received compensation from Novartis for service as a consultant and from Ariad for participation on an advisory board.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Merna A. Armanious
    • 1
    • 2
  • Shreya Mishra
    • 1
  • Michael G. Fradley
    • 1
    • 2
  1. 1.Division of Cardiovascular MedicineUniversity of South FloridaTampaUSA
  2. 2.Cardio-Oncology ProgramH. Lee Moffitt Cancer Center & Research InstituteTampaUSA

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