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Genetic Landscape and Classification of Peripheral T Cell Lymphomas

Current Oncology Reports volume 19, Article number: 28 (2017) Cite this article

Abstract

Purpose of review

Peripheral T cell lymphomas (PTCLs) are markedly heterogeneous at the clinical, pathological, and molecular levels. This review will discuss genetic findings in PTCL with special emphasis on how they impact lymphoma classification.

Recent findings

Sequencing studies have identified recurrent genetic alterations in nearly every PTCL subtype. In anaplastic large cell lymphoma, these studies have revealed novel chromosomal rearrangements and mutations that have prognostic significance and may suggest new therapeutic approaches. Angioimmunoblastic T cell lymphoma has been found to have mutations overlapping some cases of PTCL, not otherwise specified with a T follicular helper cell phenotype. Across various subtypes, recurrent mutations and structural alterations affecting genes involved in epigenetic regulation, T cell receptor signaling, and immune response may represent targets for precision therapy approaches.

Summary

New genetic findings are refining the classification of PTCLs and are beginning to be used clinically for diagnosis, risk stratification, and individualized therapy.

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Fig. 1

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Grant Support

This work was supported by award number R01 CA177734 (ALF) from the National Cancer Institute.

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  1. Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Rosalind F. Sandell, Rebecca L. Boddicker & Andrew L. Feldman

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  1. Rosalind F. Sandell
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Correspondence to Andrew L. Feldman.

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Rosalind F. Sandell, Rebecca L. Boddicker, and Andrew L. Feldman declare that they have no conflict of interest.

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Sandell, R.F., Boddicker, R.L. & Feldman, A.L. Genetic Landscape and Classification of Peripheral T Cell Lymphomas. Curr Oncol Rep 19, 28 (2017). https://doi.org/10.1007/s11912-017-0582-9

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Keywords

  • Peripheral T cell lymphoma
  • Molecular genetics
  • Angioimmunoblastic T cell lymphoma
  • Anaplastic large cell lymphoma
  • Extranodal NK/T cell lymphoma