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A Novel Approach to the Nutrigenetics and Nutrigenomics of Obesity and Weight Management

  • Integrative Care (C Lammersfeld, Section Editor)
  • Published:
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Abstract

Nutrigenetics and nutrigenomics, as well as diet and exercise, play an important role in the development and treatment of obesity and its comorbidities. If an individual’s susceptibility to becoming obese and their responsiveness to weight loss interventions are to be understood, then it needs to be addressed at a molecular and metabolic level, including genetic interaction. This review proposes a three-pillar approach to more fully comprehend the complexity of diet-gene interactions in obesity. Peroxisomal proliferating-activated receptor gamma (PPARG) and mitochondrial uncoupling protein-1 (UCP-1) are explored in detail. Illustrating how an understanding of nutritional biochemistry, nutrigenomics, and nutrigenetics may be the key to understanding differences observed in the obese phenotype that vary both within and across populations.

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Authors and Affiliations

  1. Manuka Science, 17 Roeland Square, Drury Lane, Cape Town, South Africa

    Yael T. Joffe

  2. Department of Nutritional Sciences, School of Health Related Professions, Rutgers School of Dental Medicine, Newark, NJ, USA

    Yael T. Joffe

  3. School of Human Movement Studies, University of Queensland, Brisbane, Queensland, Australia

    Christine A. Houghton

Authors
  1. Yael T. Joffe
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  2. Christine A. Houghton
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Corresponding author

Correspondence to Yael T. Joffe.

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Conflict of Interest

Yael T. Joffe is the director of Manuka Science, an educational company that teaches nutrigenetics and nutrigenomics based on the ideas expressed in this article.

Christine A. Houghton is a co-author of a Manuka Science course that teaches nutrigenetics and nutrigenomics based on ideas expressed in this article.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Integrative Care

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Joffe, Y.T., Houghton, C.A. A Novel Approach to the Nutrigenetics and Nutrigenomics of Obesity and Weight Management. Curr Oncol Rep 18, 43 (2016). https://doi.org/10.1007/s11912-016-0529-6

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  • DOI: https://doi.org/10.1007/s11912-016-0529-6

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