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Adjuvant and Neoadjuvant Options in Resectable Gastric Cancer: Is There an Optimal Treatment Approach?

  • Gastrointestinal Cancers (B Czito, Section Editor)
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Abstract

Gastric cancer is one of the most prevalent and deadliest forms of cancer worldwide. Even though neoadjuvant, perioperative, and adjuvant chemotherapy and/or radiation therapy may improve outcomes compared with surgery alone, the optimal combination of treatment modalities remains controversial. While European and North American trials established perioperative chemotherapy and adjuvant chemoradiation regimens for gastric cancer, Asian countries have focused on the use of adjuvant chemotherapy. This review summarizes results from contemporary randomized controlled trials and meta-analyses to elucidate the relative merits of each treatment approach.

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Conflict of Interest

Xuguang Chen, Jennifer R. Eads, John B. Ammori, Aryavarta M. Kumar, Tithi Biswas, and Jennifer A. Dorth declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Author information

Authors and Affiliations

  1. School of Medicine, Case Western Reserve University, Cleveland, OH, USA

    Xuguang Chen

  2. Department of Internal Medicine, Division of Hematology and Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA

    Jennifer R. Eads

  3. Department of Surgery, Division of Surgical Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA

    John B. Ammori

  4. Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA

    Aryavarta M. Kumar, Tithi Biswas & Jennifer A. Dorth

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  1. Xuguang Chen
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  2. Jennifer R. Eads
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Correspondence to Jennifer A. Dorth.

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This article is part of the Topical Collection on Gastrointestinal Cancers

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Chen, X., Eads, J.R., Ammori, J.B. et al. Adjuvant and Neoadjuvant Options in Resectable Gastric Cancer: Is There an Optimal Treatment Approach?. Curr Oncol Rep 17, 18 (2015). https://doi.org/10.1007/s11912-015-0442-4

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  • DOI: https://doi.org/10.1007/s11912-015-0442-4

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