Skip to main content

Advertisement

Log in

The Use of Dietary Supplements in Oncology

  • Integrative Care (C Lammersfeld, Section Editor)
  • Published:
Current Oncology Reports Aims and scope Submit manuscript

Abstract

The use of dietary supplements among patients affected by cancer is extensive, with an estimated 20-90 % of patients using these products. Their use of these products is often not shared with the treating physician. This is because patients perceive or believe that their physicians are indifferent or negative toward the use of dietary supplements. As a result, patients may obtain information about dietary supplements from unreliable sources, exposing themselves to unnecessary risks. Since there are limited scientific data on the efficacy and safety of many dietary supplements, advising patients about when to use them during the course of illness is a clinical challenge. Improving the communication process between the health care team and their patients in this area is critical. We describe a practical patient-centered approach to managing dietary supplement use in cancer care. This approach makes use of all available scientific data relating to the safety and efficacy of these supplements combined with how to have an open, patient-centered discussion with patients about their needs and expectations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as:• Of importance

  1. US Food and Drug Administration. Q&A on dietary supplements. http://www.fda.gov/Food/DietarySupplements/QADietarySupplements/default.htm#what_is. Accessed 8 Mar 2014.

  2. NewHope360. 2014 global supplement and nutrition industry report. http://newhope360.com/2014-global-supplement-and-nutrition-industry-report. Accessed 15 Feb 2014.

  3. Garcia-Cazarin ML, Wambogo EA, Regan KS, Davis CD. Dietary supplement research portfolio at the NIH, 2009-2011. J Nutr. 2014;144(4):414–8.

    Article  PubMed  CAS  Google Scholar 

  4. Gahche J, Bailey R, Burt V, et al. Dietary supplement use among U.S. adults has increased since NHANES III (1988–1994). NCHS data brief, no 61. Hyattsville: National Center for Health Statistics; 2011.

  5. Richardson M, Sanders T, Palmer J, et al. Complementary alternative medicine use in a comprehensive cancer center and the implications for oncology. J Clin Oncol. 2000;18:2505–14.

    PubMed  CAS  Google Scholar 

  6. Sparber A, Bauer L, Curt G, et al. Use of complementary medicine by adult patients participating in cancer clinical trials. Oncol Nurs Forum. 2000;17:623–30.

    Google Scholar 

  7. Ben-Arye E, Polliack A, Schiff E, Tadmor T, Samuels N. Advising patients on the use of non-herbal nutritional supplements during cancer therapy: a need for doctor-patient communication. J Pain Symptom Manage. 2013;46(6):887–96. The very high use of CIM treatments during cancer therapy makes it essential that treating physicians have the communication skills to understand and address their patients’ preferences and uses in these areas. This is critical as such use, especially the use of certain dietary supplements, may interact with cancer therapy.

    Article  PubMed  Google Scholar 

  8. Sandler S, Halabi S, Kaplan E, et al. Use of vitamins, minerals, and nutritional supplements by participants in a chemoprevention trial. Cancer. 2001;91:1040–5.

    Article  PubMed  CAS  Google Scholar 

  9. Newman V, Rock C, Faerber S, et al. Dietary supplement use by women at risk for breast cancer recurrence. The womens healthy eating and living study group. J Am Diet Assoc. 1998;98(3):285–92.

    Article  PubMed  CAS  Google Scholar 

  10. Von Gruenigen V, White L, Kirven M, et al. A comparison of complementary and alternative medicine use by gynecology and gynecologic oncology patients. Int J Gynecol Cancer. 2001;11(3):205–9.

    Article  Google Scholar 

  11. Paltiel O, Avitzour T, Cherny N, et al. Determinants of the use of complementary therapies by patients with cancer. J Clin Oncol. 2001;19:2439–44.

    PubMed  CAS  Google Scholar 

  12. Velicer CM, Ulrich CM. Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review. J Clin Oncol. 2008;26(4):665–73.

    Article  PubMed  CAS  Google Scholar 

  13. Kwan ML, Weltzien E, Kushi LH, Castillo A, Slattery ML, Caan BJ. Dietary patterns and breast cancer recurrence and survival among women with early-stage breast cancer. J Clin Oncol. 2009;27(6):919–26.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Moyer VA. Vitamin, mineral, and multivitamin supplements for the primary prevention of cardiovascular disease and cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014;160(8):558–64.

    Article  PubMed  Google Scholar 

  15. Guirguis-Blake J. Putting prevention into practice: routine vitamin supplementation to prevent cancer and cardiovascular disease. Am Fam Physician. 2004;70(3):559–60.

    PubMed  Google Scholar 

  16. Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. Curcumin and cancer: an "old-age" disease with an "age-old" solution. Cancer Lett. 2008;267(1):133–64.

    Article  PubMed  CAS  Google Scholar 

  17. Vahdat L, Kyriakos P, Lange D, et al. Reduction of paclitaxel-induced peripheral neuropathy with glutamine. Clin Cancer Res. 2001;7:1192–7.

    PubMed  CAS  Google Scholar 

  18. Shaikh IA, Brown I, Wahle KW, Heys SD. Enhancing cytotoxic therapies for breast and prostate cancers with polyunsaturated fatty acids. Nutr Cancer. 2010;62(3):284–96.

    Article  PubMed  CAS  Google Scholar 

  19. Ladas EJ, Kroll DJ, Oberlies NH, Cheng B, Ndao DH, Rheingold SR, et al. A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer. 2010;116:506–13.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  20. Frenkel M, Abrams D, Ladas E, et al. Integrating dietary supplements into cancer care. Integr Cancer Ther. 2013;12:369–84. This is a landmark article that assesses the real-world practice of integrative oncologists and their patients’ choices of dietary supplements. It summarizes existing data on safety and efficacy and gives practical prescribing information useful to both clinicians and patients.

    Article  PubMed  CAS  Google Scholar 

  21. Eisenberg D, Davis R, Ettner S, et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA. 1998;280:1569–75.

    Article  PubMed  CAS  Google Scholar 

  22. Frenkel M, BenArye E, Baldwin CD, Sierpina V. Approach to communicating with patients about the use of nutritional supplements in cancer care. South Med J. 2005;98(3):289–94.

    Article  PubMed  Google Scholar 

  23. Katsuya T, Maskarinec G, Shumay D, et al. Communication between physicians and cancer patients about complementary and alternative medicine: exploring patients' perspectives. Psychooncology. 2002;11:212–20.

    Article  Google Scholar 

  24. Kappauf H, Leykauf-Ammon D, Bruntsch U, et al. Use of and attitudes held towards unconventional medicine by patients in a department of internal medicine/oncology and haematology. Support Care Cancer. 2000;8(4):314–22.

    Article  PubMed  CAS  Google Scholar 

  25. Baile WF, Aaron J. Patient-physician communication in oncology: past, present, and future. Curr Opin Oncol. 2005;17(4):331–5.

    Article  PubMed  Google Scholar 

  26. Pincus HA, Patel SR. Barriers to the delivery of psychosocial care for cancer patients: bridging mind and body. J Clin Oncol. 2009;27(5):661–2.

    Article  PubMed  Google Scholar 

  27. Frenkel M, Cohen L. Effective communication about the use of complementary and integrative medicine in cancer care. J Altern Complement Med. 2014;20(1):12–8. Understanding how to communicate with patients about dietary supplements and other complementary and integrative therapies during cancer care is a complex yet critical skill. This article explores key issues in this process, and illustrates that effective communication is vital to clinicians treating patients with cancer who have questions about integrative therapies.

    Article  PubMed  Google Scholar 

  28. Frenkel M, Ben AE. Communicating with patients about the use of complementary and integrative medicine in cancer care. In: Cohen L, Markman M, editors. Integrative oncology: incorporating complementary medicine into conventional care. Totowa: Humana; 2008.

    Google Scholar 

  29. Weiger W, Smith M, Boon H. Advising patients who seek complementary and alternative medical therapies for cancer. Ann Intern Med. 2002;137(11):889–903.

    Article  PubMed  Google Scholar 

  30. Frenkel M. Components of a successful integrative medicine clinical consultation. J Soc Integr Oncol. 2008;6(3):129–33.

    PubMed  Google Scholar 

  31. Ben-Arye E, Frenkel M, Margalit RS. Approaching complementary and alternative medicine use in patients with cancer: questions and challenges. J Ambul Care Manage. 2004;27(1):53–62.

    Article  PubMed  Google Scholar 

  32. Frenkel M, Cohen L, Peterson N, Swint K, Palmer L, Bruera E. Integrative medicine consultation service in a comprehensive cancer center: findings and outcomes. Integr Cancer Ther. 2010;9(3):276–83.

    Article  PubMed  Google Scholar 

  33. Eliason B, Huebner J, Marchand L. What physicians can learn from consumers of dietary supplements. J Fam Pract. 1999;48:459–63.

    PubMed  CAS  Google Scholar 

  34. Gotay C, Dumitriu D. Health food store recommendations for breast cancer patients. Arch Fam Med. 2000;9:692–8.

    Article  PubMed  CAS  Google Scholar 

  35. Deng GE, Frenkel M, Cohen L, et al. Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals. J Soc Integr Oncol. 2009;7(3):85–120.

    PubMed  Google Scholar 

Download references

Compliance with Ethics Guidelines

Conflict of Interest

Moshe Frenkel and Victor Sierpina declare that they have no conflict of interest

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Moshe Frenkel.

Additional information

This article is part of the Topical Collection on Integrative Care

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Frenkel, M., Sierpina, V. The Use of Dietary Supplements in Oncology. Curr Oncol Rep 16, 411 (2014). https://doi.org/10.1007/s11912-014-0411-3

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11912-014-0411-3

Keywords

Navigation