Conclusions
The authors conclude that capecitabine offers a new and effective treatment option as an oral single agent for advanced colorectal carcinoma. Response rates of over 20% were seen for all groups, and the addition of leucovorin did not appear to have a marked effect on outcome except for toxicity. The intermittent single-agent capecitabine schedule was chosen for further phase III evaluation based on toxicity, dose intensity, response rate, and time to progression.
Rights and permissions
About this article
Cite this article
Bukowski, R.M. An oral fluoropyrimidine prodrug with activity in colorectal cancer. Curr Oncol Rep 3, 129–130 (2001). https://doi.org/10.1007/s11912-001-0011-x
Issue Date:
DOI: https://doi.org/10.1007/s11912-001-0011-x