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Polysomnographic Predictors of Sleep, Motor, and Cognitive Dysfunction Progression in Parkinson’s Disease

  • Sleep (M. Thorpy and M. Billiard, Section Editors)
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Abstract

Purpose of Review

Sleep disturbances are an important nonmotor feature of Parkinson’s disease (PD) that can cause polysomnographic (PSG) alterations. These alterations are already present in early PD and may be associated with a specific disease course. This systematic review describes the role of PSG variables as predictors of sleep dysfunction, motor and cognitive dysfunction progression in PD.

Recent Findings

Nineteen longitudinal cohort studies were included. Their main findings were that (1) REM sleep behavioral events, REM sleep without atonia (RSWA), and electroencephalography (EEG) changes (mainly microsleep instability) are predictors of the development of REM sleep behavior disorder (RBD); (2) RBD, RSWA, and lower slow-wave sleep energy predict motor progression; (3) RBD, EEG slowing, and sleep spindles changes are predictors of cognitive deterioration; and (4) OSA is associated with severe motor and cognitive symptoms at baseline, with inconsistent findings on the effect of continuous positive airway pressure (CPAP) therapy for these symptoms.

Summary

The results of our systematic review support a role of the video-PSG in disease progression prediction in PD and its usefulness as a biomarker. However, future studies are needed to investigate whether treatment of these PSG abnormalities and sleep disturbances may have a neuroprotective effect on disease progression.

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Funding

We thank the patient support group “Move for Parkinson”, Rotary Belgium and the Koning Boudewijn Stichting/Fondsen Druwé-Eerdekens/Van Ael/Vlaamse Parkinson Liga for their participation in funding the project. Funding sources were not involved in the research or manuscript editing.

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Authors and Affiliations

  1. Department of Neurology, Antwerp University Hospital, Drie Eikenstraat 655, 2650, Edegem, Belgium

    Femke Dijkstra, Ilse de Volder, Patrick Cras & David Crosiers

  2. Faculty of Medicine and Health Sciences, Translational Neurosciences, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium

    Femke Dijkstra, Ilse de Volder, Patrick Cras & David Crosiers

  3. Laboratory for Sleep Disorders and Department of Neurology, St.-Dimpna Regional Hospital, J.-B. Stessensstraat 2, 2440, Geel, Belgium

    Femke Dijkstra & Mineke Viaene

  4. Department of Psychiatry, Antwerp University Hospital, Drie Eikenstraat 655, 2650, Edegem, Belgium

    Ilse de Volder

  5. Multidisciplinary Sleep Disorders Center, Antwerp University Hospital, Drie Eikenstraat 655, 2650, Edegem, Belgium

    Ilse de Volder

  6. Born-Bunge Institute, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium

    Patrick Cras & David Crosiers

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Dijkstra, F., de Volder, I., Viaene, M. et al. Polysomnographic Predictors of Sleep, Motor, and Cognitive Dysfunction Progression in Parkinson’s Disease. Curr Neurol Neurosci Rep 22, 657–674 (2022). https://doi.org/10.1007/s11910-022-01226-2

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