Infantile Spasms—Have We Made Progress?

  • Sarah Aminoff Kelley
  • Kelly G. KnuppEmail author
Epilepsy (CW Bazil, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Epilepsy


Purpose of the Review

The care of children with infantile spasms is full of areas of ambiguity, despite practice parameters and randomized trials. This review is to update the current care of children with infantile spasms.

Recent Findings

Several recent studies have generated new data to guide management including a randomized trial supporting combination therapy of hormone treatment and vigabatrin as an initial treatment for infantile spasms. Studies have suggested that we are not consistent in our recognition of hypsarrhythmia, while additional studies suggest that the presence or absence of this pattern may not have any predictive value. Additionally, the use of appropriate medications as well as an early diagnosis has the most impact on short-term outcomes.


Children with infantile spasms benefit most from early diagnosis and early treatment with appropriate standard medications such as hormonal therapy (ACTH or prednisolone) or vigabatrin.


Infantile spasms Hypsarrhythmia ACTH Vigabatrin Epileptic spasms West syndrome 


Compliance with Ethical Standards

Conflict of Interest

Sarah Aminoff Kelley declares no conflict of interest.

Kelly G. Knupp has received grants from the Colorado Department of Health, PERF, and West Pharmaceuticals, as well as research funding from Zogenix and Greenwich Pharmaceuticals (DSMB).

Human and Animal Rights and Informed Consent

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).


Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Johns Hopkins HospitalBaltimoreUSA
  2. 2.University of Colorado Denver, Anschutz Medical CampusChildren’s Hospital ColoradoAuroraUSA

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